Lior Z. Braunstein
A5034069802- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Breast Implant and Reconstruction
- Global Cancer Incidence and Screening
- Acute Myeloid Leukemia Research
- HER2/EGFR in Cancer Research
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Effects of Radiation Exposure
- Cancer Risks and Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
Memorial Sloan Kettering Cancer Center
2017-2025
Harvard University
2010-2025
Massachusetts General Hospital
2025
Kettering University
2018-2024
Digital Health Cooperative Research Centre
2022
Digital China Health (China)
2022
Broad Institute
2016-2018
Dana-Farber Brigham Cancer Center
2016
Brigham and Women's Hospital
2012-2016
Dana-Farber Cancer Institute
2016
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular malignant diseases, decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed patients CH. A pro-inflammatory immunologic profile is also worse outcomes certain infections, including SARS-CoV-2 its disease Covid-19. Whether CH predisposes to severe Covid-19 other infections...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) novel 2019 (COVID-19) global pandemic has led to millions of cases and hundreds thousands deaths. While older adults appear at high risk for disease, hospitalizations deaths due SARS-CoV-2 among children have been relatively rare. Integrating single-cell RNA sequencing (scRNA-seq) developing mouse lung with temporally resolved immunofluorescence in human tissue, we found that expression Spike protein primer TMPRSS2 was highest...
A broad range of stakeholders have called for randomised evidence on the potential clinical benefits and harms proton therapy, a type radiation patients with breast cancer. Radiation therapy is an important component curative treatment, reducing cancer recurrence extending survival. Compared photon international treatment standard, reduces incidental to heart. Our overall objective evaluate whether differences between cardiac dose distributions lead meaningful reductions in morbidity...
Abstract Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state cancer patients is associated with heightened risk leukemia development. Owing technical and sample size limitations, most CH studies have characterized gene or mosaic chromosomal alterations (mCAs) individually. Here we leverage peripheral blood sequencing data from 32,442 jointly characterize ( n = 14,789) mCAs 383) CH. Recurrent composite...
For breast cancer patients undergoing neoadjuvant chemotherapy (NAC), pathologic complete response (pCR; no invasive or in situ) cannot be assessed non-invasively so all undergo surgery. The aim of our study was to develop and validate a radiomics classifier that classifies pCR post-NAC on MRI prior surgery.This retrospective included women treated with NAC for from 2014 2016 (1) pre- (2) surgical pathology report assessing response. Automated analysis involved image segmentation, feature...
The digitization of health records and growing availability tumour DNA sequencing provide an opportunity to study the determinants cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text siloed datasets. Here we combine natural language processing annotations1,2 structured medication, patient-reported demographic, registry genomic from 24,950 patients at Memorial Sloan Kettering Cancer Center generate a clinicogenomic, harmonized oncologic real-world...
The Oncotype DX® Recurrence Score (RS) is an assay for hormone receptor-positive early breast cancer with extensively validated predictive and prognostic value. However, its cost lag time have limited global adoption, previous attempts to estimate it using clinicopathologic variables had success. To address this, we assembled 6172 cases across three institutions developed Orpheus, a multimodal deep learning tool infer the RS from H&E whole-slide images. Our model identifies TAILORx high-risk...
Abstract Background Radiation therapy is one of the most commonly used cancer therapeutics but genetic determinants clinical benefit are poorly characterized. Pathogenic germline variants in ATM known to cause ataxia-telangiectasia, a rare hereditary syndrome notable for marked radiosensitivity. In contrast, somatic inactivation common event wide variety cancers, its actionability remains obscure. Methods We analyzed 20 107 consecutively treated advanced patients who underwent targeted...
Clonal hematopoiesis (CH) occurs when blood cells harboring an advantageous mutation propagate faster than others. These mutations confer a risk for hematological cancers and cardiovascular disease. Here, we analyze CH in samples from pair of twin astronauts over 4 years bulk fractionated cell populations using targeted panel, linked-read whole-genome sequencing, deep RNA sequencing. We show with distinct mutational profiles increasing allelic fraction that includes high-risk, TET2 clone one...
Purpose: Squamous cell carcinoma of the anal canal (ASCC) accounts for 2% to 4% gastrointestinal malignancies in United States and is increasing incidence; however, genomic features ASCC are incompletely characterized. Primary treatment involves concurrent chemotherapy radiation (CRT), but mutational landscape resistance CRT unknown. Here, we aim compare pre- post-CRT setting.Experimental Design: We perform whole-exome sequencing primary (n = 31) recurrent 30) ASCCs correlate findings with...
Abstract Perineural invasion (PNI) is a pathologic finding observed across spectrum of solid tumors, typically with adverse prognostic implications. Little known about how the presence PNI influences locoregional recurrence (LRR) among breast cancers. We evaluated association between and LRR an unselected, broadly representative cohort cancer patients, propensity-score matched cohort. ascertained patients seen at our institution from 2008 to 2019 for whom status salient clinicopathologic...
<h3>Importance</h3> After neoadjuvant chemotherapy (NAC), pathologic complete response (pCR) is an optimal outcome and a surrogate end point for improved disease-free overall survival. To date, surgical resection remains the only reliable method diagnosing pCR. <h3>Objective</h3> evaluate accuracy of magnetic resonance imaging (MRI)–guided biopsy pCR after NAC compared with reference-standard resection. <h3>Design, Setting, Participants</h3> Single-arm, phase 1, nonrandomized controlled...