A5100733490- Fungal Biology and Applications
- Food Quality and Safety Studies
- COVID-19 Clinical Research Studies
- Mycorrhizal Fungi and Plant Interactions
- Mosquito-borne diseases and control
- Streptococcal Infections and Treatments
- Ecology and Conservation Studies
- Viral Infections and Vectors
- Neutropenia and Cancer Infections
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Medicinal plant effects and applications
- Phytochemicals and Antioxidant Activities
- Bacterial Identification and Susceptibility Testing
- Parathyroid Disorders and Treatments
- Palliative Care and End-of-Life Issues
- COVID-19 diagnosis using AI
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Biomarkers in Disease Prognosis
- Public Health and Social Inequalities
- Consumer Attitudes and Food Labeling
- Plant-Derived Bioactive Compounds
- Plant biochemistry and biosynthesis
Ewha Womans University
2022-2025
Seoul National University
2004-2023
Gyeongsangnam-do Agricultural Research and Extension Services
2012-2021
Armed Forces Capital Hospital
2020-2021
Seoul National University Bundang Hospital
2019-2020
Boramae Medical Center
2019
Seoul Metropolitan Government
2019
Committee on Publication Ethics
2017
Ball State University
2009
Samsung Medical Center
2004
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China December 2019.In this retrospective multicenter study, we investigated the clinical course and outcomes of novel disease 2019 (COVID-19) from early cases Republic Korea.Methods: All confirmed by real time polymerase chain reaction were enrolled 1st to 28th patient nationwide.Clinical data collected analyzed for changes severity including laboratory, radiological, virologic...
Background Prioritizing patients in need of intensive care is necessary to reduce the mortality rate during COVID-19 pandemic. Although several scoring methods have been introduced, many require laboratory or radiographic findings that are not always easily available. Objective The purpose this study was develop a machine learning model predicts for with using obtainable characteristics—baseline demographics, comorbidities, and symptoms. Methods A retrospective performed nationwide cohort...
Abstract Capsiate, a nonpungent capsaicin analogue, and its dihydroderivative dihydrocapsiate are the major capsaicinoids of red pepper cultivar CH-19 Sweet. In this study, we report biological actions underlying molecular mechanisms capsiate on angiogenesis vascular permeability. vitro, inhibited endothelial growth factor (VEGF)–induced proliferation, chemotactic motility, capillary-like tube formation primary cultured human cells. They also sprouting cells in rat aorta new blood vessels...
Severe fever with thrombocytopenia syndrome (SFTS) is emerging in Asian 3 countries, China, Japan and Korea, which are scrub typhus endemic areas, its incidence increasing. As the two infections overlap epidemiologically clinically accessibility or sensitivity of diagnostic tests limited, early clinical prediction may be useful for therapeutic purposes. Patients aged ≥16 years who were suspected laboratory-confirmed to infected Orientia tsutsugamushi SFTS virus South Korea enrolled. Clinical...
MALDI-TOF MS has been successfully used for empirical antibiotic selection. However, limited data are available regarding the usefulness of in common resistant organisms compared with rapid antimicrobial susceptibility testing (AST). We prospectively evaluated AST, MS, optimal selection by infectious disease (ID) physicians patients bacteraemia including polymicrobial infection.Three hundred and fifty-nine positive blood culture were included analysis. ID decided on regimens consensus at...
A substantial number of hospitalized patients with terminal cancer at the end-of-life phase receive antibiotics, even imminent death. We evaluated impact palliative care consultation on antibiotic use in during phase.We identified adult metastatic solid who died a tertiary medical centre Seoul, Republic Korea, following least 4 days hospitalization (January 2018-December 2020). Patients were divided into and non-palliative groups. Propensity score-weighted, multivariable logistic regression...
Central line-associated bloodstream infection (CLABSI) is an important healthcare-associated infection, particularly in the intensive care unit (ICU). This study aimed to investigate impact of early infectious disease consultation (IDC) on quality metrics CLABSI patients admitted ICU. Patients with ICU were included and divided into IDC, late or never IDC groups. The group indicated whose attending physician received within 72 h onset. main outcomes proportion who optimal targeted antibiotic...
Oyster mushroom is a popular edible which has various colorful fruit bodies. The objective of this study was to determine the antioxidant and anticancer activities of oyster mushrooms (OM) with different colors such as dark-grey strain (Pleurotus ostreatus), yellow (Pleurotus cornucopiae), pink salmoneostramineus). methanolic extracts from OMs were prepared for study. Among these OMs, extract showed highest radical scavenging activity, reducing power, ferrous...
Purpose. The direct rapid antibiotic susceptibility test (dRAST), based on analysing changes in bacterial micro-colonies under conditions, detects resistance within 6 h of smear examination results. This study aimed to assess the accuracy dRAST and evaluate its potential usefulness for improving selection appropriate real clinical practice settings. Methodology. We evaluated by comparing treatments that should have been administered results broth microdilution (BMD) via simulation. Result....
Abstract The objective of the study was to develop and validate a prediction model that identifies COVID-19 patients at risk requiring oxygen support based on five parameters: C-reactive protein (CRP), hypertension, age, neutrophil lymphocyte counts (CHANeL). This retrospective cohort included 221 consecutive were randomly assigned training set test in ratio 1:1. Logistic regression, logistic LASSO Random Forest, Support Vector Machine, XGBoost analyses performed hypertension status, serial...
Abstract Objectives Issues regarding antibiotic use in end-of-life patients with advanced cancer present a challenging ethical dilemma academic referral centres. This study aimed to investigate the role of palliative care consultation on prescription patterns among hospitalized during their last days life. Methods retrospective cohort included adult metastatic solid admitted tertiary hospital for at least 4 and subsequently died who were given antibiotics before death between January 2018...
Delays in isolating patients admitted to hospital with active pulmonary tuberculosis (PTB) can contribute nosocomial transmission; however, Korea, clinically diagnosed PTB are not routinely isolated while awaiting microbiological confirmation of the diagnosis. We aimed assess extent delays and identify factors associated delayed isolation. retrospectively reviewed electronic medical records aged ≥ 18 years PTB, between January 2008 December 2017, from two Korean hospitals. Among 1,062...
Rationale: Nephropathy with concurrent invasive thymoma is a type of paraneoplastic syndrome. Patient concerns and Diagnoses: We report 32-year-old female nephrotic syndrome that was first diagnosed along treated by means cisplatin-based chemotherapy for the thymoma. The patient initially presented dyspnea generalized edema. Chest radiography computed tomography scans revealed right pleural effusion mass in middle lung field, which were confirmed percutaneous biopsy as metastatic Severe...
We report a case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in 61-year-old businessman returning from Kuwait.The patient arrived there on August 16, 2018, developed watery diarrhea 28 (day 0), and came back to Korea September 7 10) as his condition worsened.Upon arrival, he complained weakness, but denied any symptoms, directly went visit an emergency room.Chest radiography revealed interstitial infiltrates the lungs, was immediately transferred isolation...
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high mortality in East Asia.This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests differentiate between SFTS other endemic zoonoses Korea.Methods: Patients aged ≥ 18 years diagnosed during 3-year period (between January 2015 December 2017) were retrospectively enrolled from 4 tertiary university hospitals.A was built...
Scrub typhus, severe fever with thrombocytopenia syndrome (SFTS) and human granulocytic anaplasmosis (HGA) are important arthropod-borne infectious diseases in Korea share a common point that they transmitted by arthropod bites mostly during outdoor activities there considerable overlaps of epidemiologic clinical features at presentation. We investigated the co-infection these infections. The study subjects were patients laboratory-confirmed scrub typhus who enrolled retrospectively 2006....
Azole fungicides are one of the most wide-spread antifungal compounds in agriculture and pharmaceutical applications. Their major mode action is inhibition ergosterol biosynthesis, giving depletion ergosterol, precursors abnormal steroids. However, metabolic consequences such inhibition, other than steroidal metabolitesare not well established. Comprehensive profiles Saccharomyces cerevisiae has been presented this study. Wild type yeast was treated either with glucose as control or azole...
Herein, we report a case of uncomplicated falciparum malaria with late parasitological failure in 45-year-old businessman returning from Ghana. The patient visited the emergency department high fever, headache, and dizziness. He traveled without antimalarial chemoprophylaxis. Laboratory tests led to diagnosis an initial density 37,669 parasites per μL blood (p/μL). was treated intravenous artesunate followed by atovaquone/proguanil. discharged improved condition decreased parasite 887 p/μL....
버섯으로부터 새로운 생리기능성 물질을 개발을 위해 몇가지 식용 버섯들의 물 추출물들을 제조한 후 이들 추출물들의 파골세포 분화 저해활성등의 생리기능성을 측정하였다. 시료 버섯자실체들의 추출물 중, 느타리버섯의 추출물은 73.2%, 만가닥버섯은 65.3%의 비교적 높은 항고혈압성 안지오텐신 전환효소 저해활성을 보였고 73.3%의 항통풍성 잔틴 산화효소 나타내었다. 또한 만가닥버섯의 추출물이 21.5 mm투명환의 혈전용해 활성을 잣버섯 역시 40.3%의 항산화 보였으나 여타의 생리기능성은 매우 미약 하였다. 큰느타리버섯과 추출물들은 저해활성이 높았으나, 잣버섯과 추출물에서는 없었다. For development of new bioactive compounds from main edible mushrooms, we determined some physiological functionalities water extracts mushrooms. Among mushroom...