A5100348730- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- Dermatological diseases and infestations
- HIV/AIDS drug development and treatment
- Clostridium difficile and Clostridium perfringens research
- Infectious Diseases and Tuberculosis
- Patient Safety and Medication Errors
- Simulation-Based Education in Healthcare
- Urinary Tract Infections Management
- Cultural Competency in Health Care
- COVID-19 and healthcare impacts
- Antibiotic Use and Resistance
- HIV-related health complications and treatments
- Immune responses and vaccinations
- Heparin-Induced Thrombocytopenia and Thrombosis
- Medical Device Sterilization and Disinfection
Seoul National University
2002-2025
The University of Texas Health Science Center at Houston
2024-2025
Seoul Metropolitan Government
2021-2025
Boramae Medical Center
2021-2025
Gilead Sciences (United States)
2023-2024
Chiba University
2024
Seoul National University Hospital
2018-2024
National Cancer Center
2024
Armed Forces Capital Hospital
2024
Radford University
2013-2023
For ideal clinical benefit, human immunodeficiency virus (HIV)-infected individuals should receive continuous medication. This is the first nationwide antiretroviral therapy (ART) adherence study in Asia, where medication monitoring at national level systemically available. We estimated ART of incident HIV-infected and investigated factors affecting low using health insurance (NHI) claims data from 2007 to 2016. Medication possession ratio (MPR) was used measure risk were identified by...
Abstract Background Immunocompromised patients are at high risk of severe coronavirus disease 2019 (COVID-19) and death, yet treatment strategies for immunocompromised hospitalized COVID-19 reflect variations in clinical practice. In this comparative effectiveness study, we investigated the effect remdesivir on inpatient mortality among across all variants concern (VOC) periods. Methods Data between December 2020 April 2022 were extracted from US PINC AITM Healthcare Database. Patients who...
Abstract Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression used to predict anti-PD-1 therapy responses in NSCLC, its accuracy relatively less. Therefore, we sought identify more accurate predictive blood biomarker evaluating response. We evaluated the frequencies T cells, B natural killer (NK) polymorphonuclear myeloid-derived...
This comparative effectiveness study investigated the effect of remdesivir on in-hospital mortality among patients hospitalized for coronavirus disease 2019 (COVID-19) requiring supplemental oxygen including low-flow (LFO), high-flow oxygen/noninvasive ventilation (HFO/NIV), or invasive mechanical ventilation/extracorporeal membrane oxygenation (IMV/ECMO) across variant concern (VOC) periods.
Although some intravenous drugs have been used to treat coronavirus disease 2019 (COVID-19), no effective antiviral agents are currently available in the outpatient setting. We aimed evaluate efficacy and adverse events of 14-day ciclesonide treatment vs. standard care for patients with mild-to-moderate COVID-19. A randomized, open-label, multicenter clinical trial inhalers was conducted Patients were enrolled within 3 days diagnosis or 7 from symptom onset randomly assigned receive either...
Dendritic-linear block copolymers that have pH responsive poly(benzyl ether) dendrons and temperature PiPrOx chains been designed by copper-mediated click reactions. These exhibit sharp thermal transitions with a wide range of pH-dependent transition temperatures.
Background: Stroke remains a leading cause of death globally, with significant sex differences in post-stroke outcomes. Additionally, infections and sepsis are linked to innate immune responses. The glycosidase, Chitotriosidase 1 (CHIT1), has emerged as an important regulator immunity lower levels CHIT1 chitinases-like proteins associated disease severity progression including multiple sclerosis. However, whether plays role the response acute ischemic stroke is unknown. Hypothesis: We...
Introduction: Complete reperfusion (TICI 2c/3) with the fewest number of passes remains target for EVT techniques, but at present, rates remain relatively low. Prior studies have demonstrated that switching techniques between may improve reperfusion. Here we assess efficacy technique after first pass failed in a large multi-center cohort. Methods: All consecutive patients treated from 12 centers across US were prospectively collected 10/2018 – 12/2021 (SVIN Registry). Patients included if...
Background: Imaging definitions of large core infarction are highly variable. Here, we assess the performance characteristics non-contrast head CT versus perfusion at predicting final infarct volume (FIV) in patients with acute ischemic stroke (AIS) undergoing endovascular therapy (EVT). Methods: From our prospectively collected multi-center registry across four comprehensive centers (CSC) Greater Houston area, identified from 2017 to 2023 LVO AIS who received EVT. FIV was defined using MRI...
Background: Endoscopic submucosal dissection (ESD) is a representative treatment modality for early gastric neoplasms. However, the learning curve beginners performing ESD using multibending endoscope has not been introduced. Objective: This study aimed to evaluate curves of operators undergoing intensive training endoscope. Design: was retrospective single center study. Methods: We retrospectively analyzed data over 1500 consecutive ESDs performed by two A change-point analysis with 50...
Delirium during acute infection is associated with poor outcomes, although research limited due to the heterogenous nature of affected populations. Identifying risk factors for delirium can help differentiate high-risk patients. This retrospective study was carried out at a single COVID-19 designated hospital in Korea between February 2020 and May 2022. It analyzed clinical laboratory characteristics patients aged ≥75 years. COVID-19, ranging from mild severe, diagnosed by polymerase chain...
Effectively targeting treatment-resistant tumor cells, particularly cancer stem cells (CSCs) involved in recurrence, remains a major challenge immunotherapy. This study examines the potential of combining mechanical high-intensity focused ultrasound (M-HIFU) with dendritic cell (DC) vaccines to enhance immune responses against OLFM4-expressing tumors, CSC marker linked evasion and growth. M-HIFU was applied induce immunogenic death by mechanically disrupting releasing tumor-associated...
The metabolism of posaconazole is mediated mainly by uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes, especially UGT1A4. aim this study was to investigate the effects genetic polymorphisms on plasma concentration (PPC). This prospective conducted from September 2014 August 2016. We enrolled patients with acute myeloid leukemia or myelodysplastic syndrome treated oral suspension (200 mg) three times daily for fungal prophylaxis. were examined multidrug resistance gene 1 3435C>T and...
BACKGROUND Tuberculous meningitis (TBM) is the most severe form of tuberculosis, but differentiating between diagnosis TBM and viral (VM) difficult. Thus, we have developed machine-learning modules for from VM. MATERIAL AND METHODS For training data, confirmed or probable VM cases were retrospectively collected five teaching hospitals in Korea January 2000 - July 2018. Various algorithms used training. The tested by leave-one-out cross-validation. Four residents two infectious disease...
Mycobacterium marinum, a bacterium found in freshwater and saltwater, can infect persons with direct exposure to fish or aquariums. During December 2013, the New York City Department of Health Mental Hygiene learned four suspected confirmed M. marinum skin soft tissue infections (SSTIs) among who purchased whole from Chinese markets. Ninety-eight case-patients non-tuberculous mycobacteria (NTM) SSTIs were identified onset June 2013-March 2014. Of these, 77 (79%) female. The median age was 62...
Purpose. The direct rapid antibiotic susceptibility test (dRAST), based on analysing changes in bacterial micro-colonies under conditions, detects resistance within 6 h of smear examination results. This study aimed to assess the accuracy dRAST and evaluate its potential usefulness for improving selection appropriate real clinical practice settings. Methodology. We evaluated by comparing treatments that should have been administered results broth microdilution (BMD) via simulation. Result....
Statistical data of undiagnosed people living with human immunodeficiency virus (PLHIV) are great importance to (HIV) infection control. This study estimated the total number PLHIV using nationwide claims data.This used incident HIV cases identified by National Health Insurance System between 2009 and 2015. The patients acquired immune deficiency syndrome (AIDS) was diagnoses or prescription records. time diagnosis were calculated from numbers AIDS Modeling Tool European Center for Disease...
Domestic data on antiretroviral drug (ARV) resistance are limited, while alterations in ARV expected as the incidence of human immunodeficiency virus (HIV) infection increases. We evaluated ten-year change people with HIV (PWH) Korea.Adults aged ≥19 years and diagnosed between January 2010 December 2020 at a 750-bed municipal hospital were retrospectively reviewed. Data clinical characteristics mutation test results collected. The study population was divided into three-year intervals...
Abstract Background Remdesivir has demonstrated benefit in some hospitalized patients with coronavirus disease 2019 (COVID-19) on supplemental oxygen and nonhospitalized breathing room air. The durability of this across time periods different circulating severe acute respiratory syndrome 2 variants concern (VOC) is unknown. This comparative effectiveness study for COVID-19 not receiving at admission compared those starting remdesivir treatment the first days no during their hospitalization...