A5087013679- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Osteomyelitis and Bone Disorders Research
- Healthcare cost, quality, practices
- Bacterial Identification and Susceptibility Testing
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Antibiotic Use and Resistance
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
- Rheumatoid Arthritis Research and Therapies
- Bacterial Infections and Vaccines
- Health and Medical Studies
- SARS-CoV-2 detection and testing
University Hospital Cologne
2016-2025
University of Cologne
2016-2025
Centrum für Integrierte Onkologie
2016-2025
Heinrich Heine University Düsseldorf
2021-2024
Düsseldorf University Hospital
2021-2024
German Center for Infection Research
2018-2024
Universitätsklinikum Aachen
2017-2023
Weatherford College
2021
Institute of Virology of the Slovak Academy of Sciences
2021
Bernhard Nocht Institute for Tropical Medicine
2021
Variants of the SLC22A4 gene are associated with susceptibility to rheumatoid arthritis and Crohn's disease. codes for an integral membrane protein, OCTN1, that has been presumed carry organic cations like tetraethylammonium across plasma membrane. Here, we show key substrate this transporter is in fact ergothioneine (ET). Human OCTN1 was expressed 293 cells. A lead, stachydrine (alias proline betaine), identified by liquid chromatography MS difference shading, a new search strategy....
Objectives Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates coronavirus disease 19 (COVID-19) associated aspergillosis a single centre in Cologne, Germany. Methods A retrospective chart review of all patients COVID-19 ARDS admitted the medical or surgical intensive care unit University Hospital Results pulmonary was found five consecutive critically ill moderate severe...
Regular intake of cocoa-containing foods is linked to lower cardiovascular mortality in observational studies. Short-term interventions at most 2 weeks indicate that high doses cocoa can improve endothelial function and reduce blood pressure (BP) due the action polyphenols, but clinical effect low habitual on BP underlying BP-lowering mechanisms are unclear.To determine effects polyphenol-rich dark chocolate BP.Randomized, controlled, investigator-blinded, parallel-group trial involving 44...
A recent population-based study from Denmark showed that the incidence of spondylodiscitis rose 2.2 to 5.8 per 100 000 persons year over period 1995-2008; age-standardized in Germany has been estimated at 30 250 on basis data Federal Statistical Office (2015). The early diagnosis and treatment this condition are essential give patient best chance a good outcome, but these often delayed because it tends present with nonspecific manifestations, fever is absent.This article based systematic...
Innate immunity triggers responsible for viral control or hyperinflammation in COVID-19 are largely unknown. Here we show that the SARS-CoV-2 spike protein (S-protein) primes inflammasome formation and release of mature interleukin-1β (IL-1β) macrophages derived from patients but not healthy naïve individuals. Furthermore, longitudinal analyses reveal robust S-protein-driven activation isolated convalescent patients, which correlates with distinct epigenetic gene expression signatures...
Carrier-mediated transport across cell membranes is an important determinant of activity, resistance, and toxicity chemotherapeutic agents including antiretroviral (ARV) drugs (ARDs). The organic cation transporters (OCTs) 1 2 have been implicated in the translocation different cationic but so far were insufficiently tested for interactions with ARDs. Here, we assessed among commonly used human immunodeficiency virus (HIV) therapy inhibitors substrates OCTs, analyzed tissue distribution OCTs...
Abstract Purpose Knowledge regarding patients’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance understanding of COVID-19. Methods Sociodemographic and characteristics SARS-CoV-2-infected patients, enrolled LEOSS between March 16, 2020, May 14, were analyzed. Associations baseline stages diagnosis...
Circulating plasmacytoid dendritic cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha (IFNα), which is associated with disease progression. Here we show an accumulation pDC in lymph nodes (LN) treatment-naïve patients. This phenomenon was elevated expression LN homing marker, CCR7, on peripheral blood patients, conferred increased migratory capacity response to CCR7 ligands ex vivo functional assays. LN-homed patients...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global health emergency. To improve the understanding of systemic component SARS-CoV-2, we investigated if viral load dynamics in plasma and samples are associated with antibody response severity disease 2019 (COVID-19). SARS-CoV-2 RNA was found from 14 (44%) out 32 patients. RNAemia detected 5 6 fatal cases. Peak IgG values were significantly lower mild/moderate than severe (0.6 (interquartile range, IQR, 0.4–3.2) vs....
Abstract Background Timely availability of microbiological results from positive blood cultures is essential to enable early pathogen-directed therapy. The Accelerate Pheno system (ADX) a novel technology using fluorescence in situ hybridization for rapid species identification (ID) and morphokinetic bacterial analysis phenotypic antimicrobial susceptibility testing (AST), with promising results. Yet the impact this on clinical management patient outcome remains unclear. Methods We conducted...
During the SARS-CoV2 pandemic, protection measures, as well visiting restrictions, had a severe impact on seriously ill and dying patients their relatives. The study aims to describe experiences of bereaved relatives who died during regardless whether were infected with or not. As part this, related patients' end-of-life care, saying goodbye, restrictions communication healthcare team assessed.
Abstract Purpose Outpatient parenteral antimicrobial therapy (OPAT) offers several key advantages, including enhanced patient quality of life, reduced healthcare costs, and a potential reduction nosocomial infections. It is acknowledged for its safety effectiveness. This study provides the first systematic clinical data Germany, where OPAT has not yet been widely adopted. The aim to establish foundational reference point further research integration into German system. Methods prospective...
Background: The role of plasmacytoid dendritic cells (pDC) and interferon alpha (IFNα) in HIV-1 infection is still unclear. On one hand, disease associated with a progressive decline pDC, which displays reduced ability to produce IFNα after vitro challenge. the other high serum levels HIV-1-infected individuals have been proposed promote immune hyper-activation progression. Methods: We sought determine whether disappearance pDC due homing lymphoid tissues. also studied myxovirus resistance...
In Europe, intravenous fosfomycin (IV) is used particularly in difficult-to-treat or complex infections, caused by both Gram-positive and Gram-negative pathogens including multidrug-resistant strains. Here, we investigated the efficacy safety of under real-life conditions.Prospective, multi-center, non-interventional study patients with bacterial infections from 20 intensive care units (ICU) Germany Austria (NCT01173575).Overall, 209 were included (77 females, 132 males, mean age: 59 ± 16...
Abstract Purpose Vertebral osteomyelitis (VO) has a high mortality and leads to chronic pain functional disability. Surgical treatment is often necessary. To date, little known about the consequences of surgery on patient outcome. The aim this study was determine quality life (QoL) rates surgically treated VO patients for period 2 years. Methods Patients with undergoing surgical in tertiary referral hospital from 2008 2015 were included prospectively. Data collected before ( T 0) as well 1...
Review article.A review of literature on the treatment pyogenic spondylodiscitis in geriatric patients was performed with aim to give an overview about these special and a recommendation necessary diagnostics as well conservative operative options.A systematic computerized search done by working group German Society for Orthopedics Trauma Surgery.Spondylodiscitis has increasing incidence age peak at 75 years or older. The 1-year mortality without appropriate is 15 20% extremely high....