A5016645480- COVID-19 Clinical Research Studies
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Retinal Imaging and Analysis
- Cardiovascular Health and Disease Prevention
- Retinal and Optic Conditions
- Innovations in Medical Education
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Health and Lifestyle Studies
- Body Contouring and Surgery
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Clinical Reasoning and Diagnostic Skills
- Adipokines, Inflammation, and Metabolic Diseases
Clinica Universidad de Navarra
2016-2025
Navarre Institute of Health Research
2015-2022
Universidad de Navarra
2011-2021
Centro de Investigación Biomédica en Red
2020
Instituto de Salud Carlos III
2020
Hospital Universitari i Politècnic La Fe
2020
Universidad Europea
2019
Centre de Recherche en Économie et Statistique
2018
Sorbonne Paris Cité
2018
Inserm
2018
Abstract Importance COVID‐19 is caused by SARS‐CoV‐2, a betacoronavirus that uses the angiotensin‐converting enzyme‐related carboxypeptidase (ACE2) receptor to gain entry into cells. ACE2 widely expressed in multiple organs, including retina, an extension of central nervous system. The involved diabetic and hypertensive retinopathy. Additionally, coronaviruses cause ocular infections animals, retinitis, optic neuritis. Objective To assess whether there any retinal disease associated with...
The purpose of this study was to evaluate the presence retinal and microvascular alterations in COVID-19 patients with bilateral pneumonia due SARS-COV-2 that required hospital admission compare a cohort age- sex-matched controls. underwent imaging 14 days after discharge structural optical coherence tomography (OCT) angiography (OCTA) measurements. Vessel density (VD) foveal avascular zone (FAZ) area were evaluated superficial, deep capillary plexus (SCP, DCP), choriocapillaris (CC). After...
Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed relation between and events in individuals at high risk. Methods results From 31 cohorts with two scans (total n = 89070) on average 3.6 years apart clinical follow-up, subcohorts were drawn: (A) least 3 risk factors without previous CVD (B) carotid plaques (C) events. Cox regression models fit to estimate hazard ratio (HR) combined endpoint...
Abstract Background Growing evidence suggests the key role of ghrelin in onset and progression nonalcoholic fatty liver disease (NAFLD). The potential participation receptor antagonist, LEAP-2, fibrosis patients with severe obesity NAFLD through regulation TGF-β1-induced hepatic stellate cell (HSC) activation was investigated. Methods Circulating (n = 179) expression 95) LEAP-2 were measured available pathology analysis undergoing Roux-en-Y gastric bypass (RYGB). effect isoforms on HSC...
The purpose of this study was to evaluate the long-term evolution retinal changes in COVID-19 patients with bilateral pneumonia. A total 17 underwent imaging 6 months after hospital discharge structural optical coherence tomography (OCT) and angiography (OCTA). parafoveal nerve fiber layer (RNFL) ganglion cell (GCL) were significantly thinner at compared 0 (p = <0.001 both cases). In optic analysis, a RNFL observed 0.006) but persisted thickened, controls 0.02). vascular density (VD)...
Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways, genes present across spectrum histopathological in COVID-19-affected tissue. We applied correlation network-based approaches deconvolve gene expression data 46 areas interest covering more than 62,000 cells within well-preserved samples 3 patients. Despite substantial...
Objectives Hyperleptinemia and oxidative stress play a major role in the development of cardiovascular diseases obesity. This study aimed to investigate whether there is relationship between plasma levels leptin phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, its potential relevance vascular remodeling obese patients. Methods The was performed 164 94 normal-weight individuals (controls). NADPH activity evaluated by luminescence cells. Levels were quantified...
Interleukin (IL)-32 is a recently described cytokine involved in the regulation of inflammation. We aimed to explore whether IL-32 could function as an inflammatory and angiogenic factor human obesity obesity-associated type 2 diabetes. Samples obtained from 90 subjects were used study. Obese patients exhibited higher expression levels visceral adipose tissue (AT) well subcutaneous AT peripheral blood mononuclear cells. IL32 was mainly expressed by stromovascular fraction cells, its...
In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings patients infected with the new SARS-CoV2. Lung histopathology shows features and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has been found line cytokine storm theory. Medium-size vessel thrombi were frequent, but capillary not present. Despite elevation biochemical markers cardiac...
ObjectiveThe efficacy and reliability of prognostic scores has been described extensively for intensive care, but their role predicting mortality in intermediate care patients is uncertain. To provide more information this field, we have analyzed the performance Simplified Acute Physiology Score (SAPS) II SAPS 3 a single center unit (ImCU). Materials MethodsCohort study with prospectively collected data from all admitted to ImCU Pamplona, Spain, April 2006 2012. The respective predicted...
Germline GATA2 mutations have been identified as the cause of familial syndromes with immunodeficiency and predisposition to myeloid malignancies. appear loss function mutated allele leading haploinsufficiency; however, this postulate has not experimentally validated basis these syndromes. We hypothesized that are translated into abnormal proteins could affect transcription GATA2, triggering deficiency. Chromatin immunoprecipitation luciferase assays showed human protein activates its own...
Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive fatal outcome. This large-scale study characterized responses severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytometry, with aim identifying high-risk biomarkers. Holistic and unbiased analyses 17 cell-types were conducted 1,075 peripheral blood samples obtained from 868...
In hypertensive patients with heart failure (HF) a serum biomarker combination of high carboxy-terminal propeptide procollagen type-I (PICP) and low telopeptide collagen to matrix metalloproteinase-1 (CITP:MMP-1) ratio identifies histomolecular phenotype malignant myocardial fibrosis (mMF) associated severe diastolic dysfunction (DD) poor outcomes. As chronic kidney disease (CKD) facilitates MF DD, we investigated the influence CKD on mMF in HF preserved ejection fraction (HFpEF)....
Hospitalized patients are complex and institutions have to face the high cost of critical care limited resources ward. Intermediate appears as an attractive strategy provide rational according patient needs. It is interesting scenario expand co-management teaching.Retrospective observational study.Intermediate unit (ImCU) a single academic hospital.456 admitted from April 2006 2010 were included in study. Demographics, admission physiologic parameters in-hospital mortality recorded. We used...