A5040944251- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Geriatric Care and Nursing Homes
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Health Promotion and Cardiovascular Prevention
- Clinical practice guidelines implementation
- Obesity, Physical Activity, Diet
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Frailty in Older Adults
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Diet and metabolism studies
- Retinal Imaging and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Obesity and Health Practices
Vrije Universiteit Amsterdam
2013-2025
Amsterdam University Medical Centers
2008-2025
Public Health Service of Amsterdam
2022-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2023
Huisarts en Wetenschap
2016-2023
Amsterdam Public Health
2011-2020
University of Amsterdam
2000-2019
University Medical Center
2004-2018
University Hospital and Clinics
2004-2018
Sorbonne Paris Cité
2018
AimsCarotid–femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as routine tool clinical patient evaluation been hampered by the absence reference values. The aim present study is to establish and normal values PWV based on large European population.
Different definitions of the metabolic syndrome have been proposed. Their value in a clinical setting to assess cardiovascular disease (CVD) risk is still unclear. We compared proposed by National Cholesterol Education Program Adult Treatment Panel III (NCEP), World Health Organization (WHO), European Group for Study Insulin Resistance (EGIR), and American College Endocrinology (ACE) with respect prevalence association 10-year fatal nonfatal CVD.The Hoorn population-based cohort study. The...
ContextPersons with impaired glucose tolerance (IGT) are known to have an elevated risk of developing diabetes mellitus. Less is about among persons fasting (IFG) or normal levels.ObjectiveTo determine the incidence in relation baseline and postload levels other factors.Design, Setting, ParticipantsPopulation-based cohort study conducted from October 1989 February 1992 1342 nondiabetic white residents Hoorn, Netherlands, aged 50 75 years at baseline, whom plasma (FPG) 2 hours after a 75-g...
Background— Type 2 diabetes (DM-2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. In nondiabetic individuals, arterial stiffness is important cause of disease. Associations between DM-2 IGM have not been systematically investigated. Methods Results— a population-based cohort (n=747; 278 normal metabolism, 168 IGM, 301 DM-2; mean age, 68.5 years), was ultrasonically estimated by distensibility compliance the carotid, femoral, brachial...
Impaired glucose metabolism (IGM) and type 2 diabetes (DM-2) are associated with high cardiovascular disease risk. Increases in peripheral central artery stiffness may represent pathophysiologic pathways through which tolerance status leads to disease. Peripheral increases deteriorating status, whereas this trend remains unclear for stiffness. Therefore, we investigated the associations between estimates of arterial We performed a population-based study 619 individuals (normal metabolism,...
OBJECTIVE—To study potential risk factors for retinopathy in diabetic and nondiabetic individuals. RESEARCH DESIGN AND METHODS—The Hoorn Study is a population-based including 2,484 50- to 74-year-old Caucasians. A subsample of 626 individuals stratified by age, sex, glucose tolerance underwent extensive measurements during 1989–1992, ophthalmologic examination two-field 45-degree fundus photography. The prevalence (diabetic) was assessed among with normal metabolism (NGM) impaired (IGM)...
OBJECTIVE—Waist and hip circumferences have been shown to independent opposite associations with glucose levels. Waist circumference is positively associated levels, whereas negatively associated. It unclear which tissues are involved in the pathophysiological mechanism causing these associations. The main goal was determine tissue trunk legs, fat or lean tissue, measures of metabolism. RESEARCH DESIGN AND METHODS—In 623 participants third examination Hoorn Study, whole-body dual-energy...
Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD), but longitudinal observations are limited and the precise magnitude unknown. We prospectively assessed incidence CVD in patients RA compared type 2 diabetes mellitus (DM) general population.The 3-year rate was determined a prospective cohort (the Cardiovascular Research Arthritis Study) 353 outpatients RA, that 1,852 population-based study participants (155 had DM). investigated fatal nonfatal...
Patients with rheumatoid arthritis (RA) have an increased cardiovascular risk, but the magnitude of this risk is not known precisely. A study was undertaken to investigate associations between RA and type 2 diabetes (DM2), a well-established factor, on one hand, disease (CVD) other.The prevalence CVD (coronary, cerebral peripheral arterial disease) determined in 353 randomly selected outpatients (diagnosed 1989 2001, aged 50-75 years; CARRE study) participants population-based cohort (the...
Social jetlag represents the discrepancy between circadian and social clocks, which is measured as difference in hours midpoint of sleep work days free days. Previous studies have shown to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symptoms, smoking, mental distress alcohol use. The objective our current study was investigate, a group 145 apparently healthy participants (67 men 78 women, aged 18-55 years, BMI 18-35 kg/m(2)), prevalence its...
Abstract Purpose To increase the efficiency of retinal image grading, algorithms for automated grading have been developed, such as IDx‐DR 2.0 device. We aimed to determine ability this device, incorporated in clinical work flow, detect retinopathy persons with type 2 diabetes. Methods Retinal images treated by Hoorn Diabetes Care System (DCS) were graded device and independently three specialists using International Clinical Diabetic Retinopathy severity scale (ICDR) EURODIAB criteria....