A5059691866- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Hemoglobin structure and function
- Hemodynamic Monitoring and Therapy
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular and exercise physiology
- Neonatal Health and Biochemistry
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Non-Invasive Vital Sign Monitoring
- Cardiac pacing and defibrillation studies
- Erythrocyte Function and Pathophysiology
- Hormonal Regulation and Hypertension
- Telomeres, Telomerase, and Senescence
- Cardiac Arrhythmias and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Kidney Disease and Diabetes
- Infrared Thermography in Medicine
- Birth, Development, and Health
Ghent University Hospital
2016-2025
Ghent University
2011-2024
Renson (Belgium)
2024
Universitair Ziekenhuis Brussel
1990-2020
University of Pennsylvania
2009-2018
iMinds
2014-2016
KU Leuven
2002-2014
Philadelphia VA Medical Center
2009-2014
Hospital of the University of Pennsylvania
2014
Baker Heart and Diabetes Institute
2014
AimsCarotid–femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as routine tool clinical patient evaluation been hampered by the absence reference values. The aim present study is to establish and normal values PWV based on large European population.
It is uncertain whether ambulatory blood-pressure measurements recorded for 24 hours in patients with treated hypertension predict cardiovascular events independently of obtained the physician's office and other risk factors.We assessed association between base-line blood pressures subsequent among 1963 a median follow-up 5 years (range, 1 to 66 months).We documented new 157 patients. In Cox proportional-hazards model adjustment age, sex, smoking status, presence or absence diabetes...
Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, inflammatory markers. In present study, we examined ability of FFQ-derived dietary index (DII) to predict Data from Belgian cross-sectional study 2524 generally healthy subjects (age 35–55 years) were used. The DII population-based, literature-derived was developed inflammation inflammation-related chronic diseases. calculated...
Summary Evidence assembled over the last decade shows that average telomere length (TL) acts as a biomarker for biological aging and cardiovascular disease (CVD) in particular. Although essential more profound understanding of underlying mechanisms, little reference information is available on TL. We therefore sought to provide baseline TL assess association prevalent CVD risk factors with subjects free overt within small age range. measured mean restriction fragment peripheral blood...
Objective— Two types of endothelial progenitor cells (EPCs), early EPCs and late (also called outgrowth [EOCs]), were described in vitro previously. In this report, we dissect the phenotype precursor(s) that generate these cell with focus on markers CD34, CD133, vascular growth factor receptor-2 (VEGFR2) have been used to identify putative circulating precursors. We also included CD45 analysis assess relation between CD34 + hematopoietic progenitors (HPC), precursors, both generated EPC...
The relation between arterial function indices, such as pulse wave velocity and augmentation index with parameters derived from input impedance analysis, is still incompletely understood. Carotid pressure, central flow waveforms, were noninvasively acquired in 2026 apparently healthy, middle-aged subjects (1052 women 974 men) 35 to 55 years old at inclusion. Input characteristic impedance, reflection coefficient, the ratio of backward-to-forward pressure amplitude (reflection magnitude),...
The need for left ventricular mass (LVM) normalization to body size is well recognized. Currently used allometric exponents normalize LVM may not account the confounding effect of sex. Because sex a strong determinant and LVM, we hypothesized that these are subject potential bias. We analyzed data from 7528 subjects enrolled in Asklepios Study (n=2524) Multiethnic Atherosclerosis (limited access set; n=5,004) assess metric relationships between size, generate normative indexed compare...
As with every -omics technology, metabolomics requires new methodologies for data processing. Due to the large spectral size, a standard approach in NMR-based implies division of spectra into equally sized bins, thereby simplifying subsequent analysis. Yet, disadvantages are loss information and occurrence artifacts caused by peak shifts. Here, binning algorithm, Adaptive Intelligent Binning (AI-Binning), which largely circumvents these problems, is presented. AI-Binning recursively...
Central-to-peripheral amplification of the pressure pulse leads to discrepancies between central and brachial blood pressures. This depends on an individual’s hemodynamic (patho)physiological characteristics. The aim this study was assess magnitude correlates central-to-peripheral in upper limb a healthy, middle-aged population (the Asklepios Study). Carotid, brachial, radial waveforms were acquired noninvasively using applanation tonometry 1873 subjects (895 women) aged 35 55 years....
Although evidence supports the function of telomere length (TL) as a marker for biological aging, no major determinants TL are known besides inheritance, age and gender. Here we validate and, more importantly, assess impact paternal at birth determinant offspring's peripheral blood leukocyte within Asklepios study population. Telomere restriction fragment information were available 2433 volunteers (1176 men 1257 women) aged ~35–55 years old. Paternal was positively associated with offspring...
The Asklepios Study is a longitudinal population study focusing on the interplay between ageing, cardiovascular haemodynamics and inflammation in (preclinical) disease. 2524 participants (1301 women) are representative cohort of 35-55-year-old individuals, free from overt disease at initiation, randomly sampled twinned Belgian communities Erpe-Mere Nieuwerkerken. Baseline examinations (all single-observer, single-device, single-site, single 2-year consecutive timeframe) include:...
Background: We have previously shown that in healthy young men, a less favorable body composition is associated with higher free triiodothyronine (fT3) levels within the euthyroid range. Besides, free-triiodothyronine-to-free-thyroxin (fT3-to-fT4) ratio has been related to metabolic phenotype and more placental growth pregnant women. In present study, we therefore investigated whether serum thyrotropin (TSH), thyroid hormone levels, fT3-to-fT4 are adiposity-related cardiovascular risk...
The relationship between aortic (carotid-femoral) pulse wave velocity and stiffness measures based on local diameter pressure readings is not yet fully understood.We compared the with age gender of to indices (compliance distensibility coefficient) evaluated at common carotid femoral arteries in 2195 (1131 women) apparently healthy subjects, aged 35-55 years participating Asklepios study. Aortic was further previously reported central arterial parameters same population. Subjects were...