A5016588114- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Hemodynamic Monitoring and Therapy
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Sodium Intake and Health
- Retinal Diseases and Treatments
- Pain Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
Steno Diabetes Centers
2016-2025
University of Copenhagen
2009-2025
Capital Region of Denmark
2009-2025
Universidad de la República de Uruguay
2008-2023
Danish Diabetes Association
2022-2023
Ruijin Hospital
2008-2023
KU Leuven
2006-2023
Shanghai Institute of Hypertension
2010-2023
Hospital de Clínicas
2008-2023
Anna Needs Neuroblastoma Answers
2023
AimsCarotid–femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as routine tool clinical patient evaluation been hampered by the absence reference values. The aim present study is to establish and normal values PWV based on large European population.
Few population studies addressed the prognostic significance of aortic pulse wave velocity (APWV) above and beyond other cardiovascular risk factors.We studied a sex- age-stratified random sample 1678 Danes aged 40 to 70 years. We used Cox regression investigate value APWV, office pressure (PP), 24-hour ambulatory PP while adjusting for mean arterial (MAP) covariates. Over median follow-up 9.4 years, incidence fatal nonfatal end points, mortality, coronary heart disease amounted 154, 62, 101...
In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP SD average real 24-hour ambulatory recordings. computed standardized hazard ratios (HRs) while stratifying by cohort adjusting for other risk factors. Over 11.3 years (median), 1242 deaths...
<h3>Importance</h3> Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal nonfatal outcomes. It uncertain which BP index most strongly associated with these <h3>Objective</h3> To evaluate the association of indexes death composite CV event. <h3>Design, Setting, Participants</h3> Longitudinal population-based cohort study 11 135 adults from Europe, Asia, South America baseline observations collected May 1988 to 2010 (last follow-ups, August...
Background We and other investigators previously reported that isolated nocturnal hypertension on ambulatory measurement (INH) clustered with cardiovascular risk factors was associated intermediate target organ damage. investigated whether INH might also predict hard endpoints. Methods results monitored blood pressure (BP) throughout the day followed health outcomes in 8711 individuals randomly recruited from 10 populations (mean age 54.8 years, 47.0% women). Of these, 577 untreated had...
Low-grade inflammation is thought to contribute the development of cardiovascular disease (CVD), type-2 diabetes mellitus (T2D), cancer and mortality. Biomarkers may aid in risk prediction enable early intervention prevention disease.The aim this study was investigate whether plasma levels inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) are predictive mortality general population.This an observational prospective cohort study. Cohort participants were included...
It is unclear whether subclinical vascular damage adds significantly to Systemic Coronary Risk Evaluation (SCORE) risk stratification in healthy subjects. In a population-based sample of 1968 subjects without cardiovascular disease or diabetes not receiving any cardiovascular, anti-diabetic, lipid-lowering treatment, aged 41, 51, 61, 71 years, we measured traditional factors, left ventricular (LV) mass index, atherosclerotic plaques the carotid arteries, carotid/femoral pulse wave velocity...
Current diagnostic thresholds for ambulatory blood pressure (ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven frame ABP measurement.We performed 24-hour monitoring in 5682 participants (mean age 59.0 years; 43.3% women) enrolled prospective population studies Copenhagen, Denmark; Noorderkempen, Belgium; Ohasama, Japan; and Uppsala, Sweden. In multivariate analyses, we thresholds, which yielded 10-year cardiovascular risks similar...
Previous studies on the prognostic significance of morning blood pressure surge (MS) produced inconsistent results. Using International Database Ambulatory Blood Pressure in Relation to Cardiovascular Outcome, we analyzed 5645 subjects (mean age: 53.0 years; 54.0% women) randomly recruited 8 countries. The sleep-through and preawakening MS were differences with lowest nighttime pressure, respectively. We computed multivariable-adjusted hazard ratios comparing risk ethnic- sex-specific...
The relationship between ambulatory blood pressure and mortality in a general Western population is unknown. Therefore, we conducted this prospective study of random sample 1700 Danish men women, aged 41 to 72 years, without major cardiovascular diseases. At baseline, pressure, office other risk factors were recorded. After mean period 9.5 174 had died: 63 deaths. In multivariate proportional hazards models, adjusted for significance, the relative (95% confidence interval) associated with 10...
Background:Information on the relationship between ambulatory blood pressure (BP) and cardiovascular disease in general population is sparse.
Abstract The effect of the insulinotropic incretin hormone, glucagon-like peptide-1 (GLP-1), is preserved in typical middle-aged, obese, insulin-resistant type 2 diabetic patients, whereas a defective amplification so-called late-phase plasma insulin response (20–120 min) to glucose by other glucose-dependent polypeptide (GIP), seen these patients. aim present investigation was evaluate and C-peptide responses GLP-1 GIP five groups patients with etiology phenotype distinct from obese We...
The ambulatory arterial stiffness index (AASI) can be computed from individual 24-h blood pressure recordings.We investigated the prognostic value of AASI and pulse in a random sample 1829 Danes, aged 40-70 years. We adjusted for sex, age, body mass index, mean pressure, smoking, diabetes, ratio total to high-density lipoprotein cholesterol, history cardiovascular disease with Cox regression.Over median follow-up 9.4 years, incidences fatal nonfatal endpoints were 40 stroke, 150 coronary...
Outcome-driven recommendations about time intervals during which ambulatory blood pressure should be measured to diagnose white-coat or masked hypertension are lacking. We cross-classified 8237 untreated participants (mean age, 50.7 years; 48.4% women) enrolled in 12 population studies, using ≥140/≥90, ≥130/≥80, ≥135/≥85, and ≥120/≥70 mm Hg as thresholds for conventional, 24-hour, daytime, nighttime pressure. White-coat was on conventional measurement with normotension, the opposite...