A5080453261- Influenza Virus Research Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- HIV Research and Treatment
- Cervical Cancer and HPV Research
- T-cell and Retrovirus Studies
- HIV/AIDS drug development and treatment
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Parasitic Diseases Research and Treatment
- Virology and Viral Diseases
- COVID-19 diagnosis using AI
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
Navarre Institute of Health Research
2016-2025
Clinica Universidad de Navarra
2016-2025
Universidad de Navarra
2010-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2024
University of Milan
2024
Universidad de Murcia
2024
Harvard University
2021
Barcelona Institute for Global Health
2020
University Hospital of Bern
2020
Saarland University
2016
•First cases of acute hepatitis related to Orthohepevirus C infection in Europe.•Second registered death worldwide an immunosuppressed individual.•Screening for RNA should be evaluated all patients with hepatitis. Background & AimHepatitis E virus (HEV) was considered the only member Hepeviridae family zoonotic potential. Nevertheless, this consideration has been reassessed owing several reported and chronic linked genus. Because circulation rodents described worldwide, risk transmission is...
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COVID-19 patients elicit strong responses to the nucleocapsid (N) protein of SARS-CoV-2 but binding antibodies are also detected in prepandemic individuals, indicating potential crossreactivity with common cold human coronaviruses (HCoV) and questioning its utility seroprevalence studies. We investigated immunogenicity full-length shorter fragments N protein, HCoV. identified a C-terminus region SARS-CoV2 minimal sequence homology HCoV that was more specific for highly immunogenic. IgGs...
Reliable serological tests are required to determine the prevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and characterize immunity disease in order address key knowledge gaps 2019 (COVID-19) pandemic. Quantitative suspension array technology (qSAT) assays based on xMAP Luminex platform overcome limitations rapid diagnostic enzyme-linked immunosorbent (ELISAs) with their higher precision, dynamic range, throughput, miniaturization,...
Nipah virus (NiV) is an emerging zoonotic paramyxovirus to which attributed numerous high mortality outbreaks in South and South-East Asia; Bangladesh’s belt accounts for the vast majority of human outbreaks, reporting regular viral emergency events. The natural reservoir NiV Pteropus bat species, covers a wide geographical distribution extending over Asia, Oceania, Africa. Occasionally, have required presence intermediate amplification mammal host between humans. However, Bangladesh,...
Abstract Background Obesity-associated dysfunctional intestinal permeability contributes to systemic chronic inflammation leading the development of metabolic diseases. The inflammasomes constitute essential components in regulation homeostasis. We aimed determine impact gut barrier dysfunction and context obesity type 2 diabetes (T2D). Methods Blood samples obtained from 80 volunteers ( n = 20 normal weight, 21 OB without T2D, 39 with T2D) a subgroup jejunum were used case–control study....
HCV affects 185 million people worldwide and leads to death morbidities. has a high genetic diversity is classified into seven genotypes 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance cure rates depend on geno/subtype (GT).Analysis of epidemiological information viral GT from patients undergoing genotyping in 2011-2015.Anonymized 52 centers was analyzed retrospectively.37,839 samples were included the study. We show that distribution similar throughout...
The hepatitis E virus (HEV) is a widespread human infection that causes mainly acute and can evolve to chronic manifestation in immunocompromised individuals. In addition the common strains of (HEV-A), known as Paslahepevirus balayani, pathogenic humans, genetically highly divergent rat origin hepevirus (RHEV) cause possessing potential risk cross-species zoonotic transmission. Rocahepevirus ratti, formerly Orthohepevirus C, single-stranded RNA virus, recently reassigned genus Hepeviridae...
Some studies have evaluated vaccine effectiveness in preventing outpatient influenza while others analysed its hospitalizations. This study evaluates the of trivalent illness and hospitalizations from laboratory-confirmed 2010–2011 season. We conducted a nested case–control population covered by general practitioner sentinel network for surveillance Navarre, Spain. Patients with influenza-like hospitals primary health care were swabbed testing. Influenza vaccination status other covariates...
We aimed to evaluate the correct assignment of HCV genotypes by three commercial methods—Trugene genotyping kit (Siemens), VERSANT Genotype 2.0 assay and Real-Time genotype II (Abbott)—compared NS5B sequencing. studied 327 clinical samples that carried representative most frequent geno/subtypes in Spain. After genotyping, sequencing a 367 bp fragment gene was used assign genotypes. Major discrepancies were defined, e.g. differences assigned one methods sequencing, including misclassification...
The development of tools that provide early triage COVID-19 patients with minimal use diagnostic tests, based on easily accessible data, can be vital importance in reducing mortality rates during high-incidence scenarios. This work proposes a machine learning model to predict and risk hospitalization using both 2 simple demographic features 19 comorbidities obtained from 86,867 electronic medical records patients, new method (LR-IPIP) designed deal data imbalance problems. was able high...
The emergence of new variants and diverse vaccination regimens have raised uncertainty about vaccine effectiveness against SARS-CoV-2. This study aims to investigate the impact Omicron primo-/reinfection primary schedules on immunogenicity an mRNA-based booster dose over a six-month period. We conducted prospective cohort assess durability level antibodies 678 healthcare workers fully vaccinated COVID-19. They were categorized based their regimen. Blood samples collected before 1 6 months...
ABSTRACT Long COVID is an emerging condition with important impact on the quality of life affected individuals. This study aims to analyse association between complete vaccination prior SARS‐CoV‐2 infection and subsequent development long COVID, including its symptoms their frequency through a retrospective case–control study. Cases included participants while controls were without but who had infection. Data collected self‐reported survey. The demonstrates significant lower incidence...
Many studies have investigated symptoms, comorbidities, demographic factors, and vaccine effects in relation to long COVID (LC-19) across global populations. However, a number of these shortcomings, such as inadequate LC-19 categorisation, lack sex disaggregation, or narrow focus on certain risk factors like symptoms comorbidities alone. We address gaps by investigating the present during acute phase primary COVID-19 infection among patients with comparing them typical non-Long patients....
Ivermectin (IVM), an antiparasitic drug, was repurposed to treat COVID-19 based on its in vitro antiviral effects. However, it abandoned after multiple clinical trials reported a lack of efficacy. Immunomodulatory effects have been proposed but remain unclear, yet they may be relevant given IVM use for other infections. We assessed the immunomodulatory effect 24 participants from trial evaluating potential reduce transmission mild cases within 48 hours symptoms onset. The IVM-treated...