A5073786260- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Glycosylation and Glycoproteins Research
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Sex and Gender in Healthcare
- Health, psychology, and well-being
- Advanced MRI Techniques and Applications
- Health and Well-being Studies
- Ophthalmology and Visual Health Research
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Endometriosis Research and Treatment
- Biochemical and Molecular Research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
University of Siena
2004-2025
Azienda Ospedaliera Universitaria Senese
2021
Istituto per le Tecnologie Didattiche
2019
Institute of Biomedical Technologies
2019
Ospedale Santa Maria alle Scotte
2018
Universidad de Valladolid
2016
HCV affects 185 million people worldwide and leads to death morbidities. has a high genetic diversity is classified into seven genotypes 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance cure rates depend on geno/subtype (GT).Analysis of epidemiological information viral GT from patients undergoing genotyping in 2011-2015.Anonymized 52 centers was analyzed retrospectively.37,839 samples were included the study. We show that distribution similar throughout...
To assess the prevalence of hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) resistance mutations in HCV genotype 1-infected PI-naive individuals Italy. One hundred and twelve patients infected with 1a or 1b (based on Versant Genotype 2.0 5′UTR/core sequencing) never treated any PI were evaluated. The whole NS3 region was analysed by population sequencing related to linear macrocyclic PIs recorded. Forty-six HCV-monoinfected 66 HCV/HIV-coinfected subjects studied. Complete sequence...
Abstract Background. Hepatitis C virus (HCV) genotype 1 is the most prevalent worldwide. Subtype 1a, compared with 1b, shows lower response rates and higher propensity to select for drug resistance NS3 selected NS5A nonnucleoside NS5B inhibitors. Two distinct clades of subtype 1a have been described. Methods. Using Bayesian methodology, we performed a time-scaled phylogeny reconstruction clade separation characterized geographic distribution, phylodynamics, association natural variants...
Abstract Objectives To investigate resistance-associated substitutions (RASs) as well retreatment efficacies in a large cohort of European patients with failure glecaprevir/pibrentasvir. Methods Patients were identified from three Resistance Reference centres Spain, Italy and Germany. Sequencing NS3, NS5A NS5B was conducted associated resistance to direct antiviral agents analysed. Clinical virological parameters documented retrospectively evaluated. Results We evaluated 90...
A new restriction fragment length polymorphism (RFLP) analysis has been developed for hepatitis C virus (HCV) typing in the viral 5′ non-coding region and contiguous core region. These genomic sequences were chosen relative nucleotide homology among different genotypes presence of polymorphic sites. By employing two endonucleases (<i>Acc</i>I <i>Mbo</i>I) and, some instances, a third one (<i>Eco</i>RII), we can unambiguously reproducibly distinguish...
A 72 year old man developed chronic sensory neuropathy (CSN) during hepatitis C (HCV) infection. Neurological symptoms began one after acute HCV and slowly worsened over three years. No conventional cause for CSN was found. Circulating antinervous tissue antibodies (including anti-Hu) inflammatory infiltrates in sural nerve biopsy specimens were absent. However, the presence of anti-HCV antibody HCV-RNA cerebrospinal fluid indicated that had reached intrathecal compartment, suggesting direct...
ABSTRACT In a prospective study of 33 infants born to hepatitis C virus (HCV)-positive human immunodeficiency virus-negative mothers the vertical transmission HCV occurred in 6.8%. The evolution infection two babies was studied from birth up 5 or 6 years age, and sequencing hypervariable region (HVR) putative envelope-encoding E2 genome performed. HVR1 sequence variability different serological profiles during follow-up could reflect differences routes, genotypes, clinical infection.
Maraviroc is an HIV-1 coreceptor antagonist that has shown good efficacy and tolerability in treatment-naive treatment-experienced patients harboring CCR5-tropic virus. The use of treatment simplification with suppressed plasma RNA requires analysis DNA. Coreceptor tropism testing often performed remotely at reference laboratories. In this study paired whole blood stored + 4°C at−20°C were compared as a source for genotypic testing. Two hundred samples from different analysed. Each sample...
Preexistence and appearance of resistance-associated substitutions limit the efficacy direct-acting antivirals in treatment hepatitis C. This is first case report an adolescent with chronic C virus genotype 4 infection cirrhosis who failed ombitasvir/paritaprevir/ritonavir ribavirin. Resistance analysis showed baseline M28V Y93C emergent D168H.