A5014007294- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Heat shock proteins research
- thermodynamics and calorimetric analyses
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Cardiovascular Health and Disease Prevention
- Effects of Environmental Stressors on Livestock
- Heart Rate Variability and Autonomic Control
- Long-Term Effects of COVID-19
- Inhalation and Respiratory Drug Delivery
- Pleural and Pulmonary Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Glycogen Storage Diseases and Myoclonus
- Immune Response and Inflammation
- Biomarkers in Disease Mechanisms
- Thermal Regulation in Medicine
- Psoriasis: Treatment and Pathogenesis
- Design Education and Practice
- Peptidase Inhibition and Analysis
Istituti Clinici Scientifici Maugeri
2020-2025
Fondazione Istituto G. Giglio di Cefalù
2005-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2011
Fondazione Salvatore Maugeri
2002
Summary There are increased numbers of activated T lymphocytes in the bronchial mucosa stable chronic obstructive pulmonary disease (COPD) patients. helper type 17 (Th17) cells release interleukin (IL)-17 as their effector cytokine under control IL-22 and IL-23. Furthermore, Th17 some inflammatory conditions. To investigate expression (IL)-17A, IL-17F, IL-21, IL-23 retinoic orphan receptor RORC2, a marker cells, biopsies from patients with COPD different severity compared age-matched...
<h3>Background:</h3> Increased numbers of activated neutrophils have been reported in the bronchial mucosa patients with stable chronic obstructive pulmonary disease (COPD), particularly severe disease. <h3>Objectives:</h3> To investigate expression neutrophilic chemokines and adhesion molecules biopsies from COPD different severity (GOLD stages I–IV) compared age-matched control subjects, smokers normal lung function never smokers. <h3>Methods:</h3> The CCL5, CXCL1, 5, 6, 7 8, CXCR1, CXCR2,...
The relation between smoking, chronic obstructive pulmonary disease (COPD), and lung cancer (LC) is an open field of investigation. A higher frequency adenocarcinoma has been reported in patients with COPD. Heat shock proteins (Hsps) are implicated tumoral cell growth differentiation. aim the present study was to investigate expression Hsp60 Hsp10 bronchial biopsies from smokers COPD 10 evaluate association Hsps carcinogenetic steps LC.An immunohistochemical performed for 35...
Background It is increasingly clear that some heat shock proteins (Hsps) play a role in inflammation. Here, we report results showing participation of Hsp60 the pathogenesis chronic obstructive pulmonary diseases (COPD), as indicated by data from both vivo and vitro analyses. Methods Results Bronchial biopsies patients with stable COPD, smoker controls normal lung function, non-smoker were studied. We quantified immunohistochemistry levels Hsp10, Hsp27, Hsp40, Hsp60, Hsp70, Hsp90, HSF-1,...
Background: Endothelial dysfunction has been proposed as the common pathogenic background of most manifestations coronavirus disease 2019 (COVID-19). Among these, some authors also reported an impaired exercise response during cardiopulmonary testing (CPET). We aimed to explore potential association between endothelial and reduced CPET performance in COVID-19 survivors. Methods: 36 consecutive survivors underwent symptom-limited incremental assessment endothelium-dependent flow-mediate...
The protease–antiprotease balance is involved in many biological processes, including blood coagulation, tissue remodeling, inflammation and immune responses. aim of this study to determine the between SERPINs some related proteases lungs stable COPD patients. In cross-sectional study, expression localization human (anti-proteases) were measured lung parenchyma mild-moderate (MCOPD, n = 13) patients, control smokers (CS, 14) nonsmokers (CNS, 12) using transcriptome analysis,...
Accurate diagnosis and management of bronchial asthma are complex processes guided by national international guidelines, particularly the Global Initiative for Asthma (GINA). However, adherence to these guidelines is often suboptimal, varying across healthcare professionals countries, which can lead poor control increased costs. In this observational study, we assessed alignment GINA recommendations in among 15 primary care physicians two metropolitan areas Campania region, Southern Italy....
<b><i>Background:</i></b> The literature shows conflicting results when high-resolution computed tomography (HRCT) scores of emphysema were correlated with different indices airflow obstruction. <b><i>Objectives:</i></b> We HRCT <b><i>Methods:</i></b> performed the chest in 59 patients, all smokers or ex-smokers, stable chronic obstructive pulmonary disease severity [GOLD stages I–IV; mean age ± SD 67.8 7.3 years;...
Background: Bone morphogenic proteins (BMPs) and their antagonists are involved in the tissue development homeostasis of various organs. Objective: To determine transcriptomic protein expression BMPs stable COPD. Methods: We measured localization some relevant bronchial biopsies mild/moderate COPD (MCOPD) (n = 18), severe/very severe (SCOPD) 16), control smokers (CS) 13), non-smokers (CNS) 11), lung parenchyma MCOPD 9), CS CNS 9) using immunohistochemistry transcriptome analysis, vitro after...
Notch signaling is involved in the prevention of cell differentiation and fate various organs, including lungs. We aimed to determine transcriptomic protein expression receptors, their ligands, related transcription factors stable COPD. The localization were measured bronchial biopsies individuals with mild/moderate (MCOPD) (n = 18) or severe/very severe (SCOPD) 16) COPD, control smokers (CSs) 13), nonsmokers (CNSs) 11), lung parenchyma those MCOPD CSs 10), CNSs 10) using...
Heat-shock protein (Hsp)10 is the co-chaperone for Hsp60 inside mitochondria, but it also resides outside organelle. Variations in its levels and intracellular distribution have been documented pathological conditions, e.g. cancer chronic obstructive pulmonary disease (COPD). Here, we show that Hsp10 COPD undergoes changes at molecular subcellular bronchial cells from human specimens derived cell lines, intact or subjected to stress induced by cigarette smoke extract (CSE). Noteworthy...
Identification of COPD patients with a rapid decline in FEV1 is particular interest for prognostic and therapeutic reasons.To determine the expression markers inflammation functional comparison to slow or no decliners.In monitored at least 3 years (mean ± SD: 5.8 years) lung decline, localization inflammatory was measured bronchial biopsies (FEV1% + 30 43 ml/year, n = 21), - 40 19, 14) 112 53, 15) using immunohistochemistry. ELISA test used polymeric immunoglobulin receptor (pIgR)...
As reported by the World Health Organization (WHO), about 10-20% of people have experienced mid- to long-term effects following SARS-CoV-2 infection, collectively referred as post-COVID-19 condition or long-COVID, including some neurovegetative symptoms. Numerous findings suggested that onset these symptoms upon viral infection may be caused production autoantibodies through molecular mimicry phenomena. Accordingly, we had previously demonstrated 22 human proteins sharing putatively...
Background: Little is known about the innate immune response to viral infections in stable Chronic Obstructive Pulmonary Disease (COPD). Objectives: To evaluate mediators related respiratory viruses bronchial biopsies and lung parenchyma of COPD patients. Methods: We evaluated immunohistochemical (IHC) expression Toll-like receptors 3-7-8-9 (TLR-3-7-8-9), TIR domain-containing adaptor inducing IFNβ (TRIF), Interferon regulatory factor 3 (IRF3), Phospho interferon 3 ( pIRF3), 7 (IRF7),...