A5102028040- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cancer Diagnosis and Treatment
- Comparative International Legal Studies
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Testicular diseases and treatments
- Legal processes and jurisprudence
- Prostate Cancer Treatment and Research
- Oral and Maxillofacial Pathology
- Glioma Diagnosis and Treatment
- Comparative constitutional jurisprudence studies
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Administrative Law and Governance
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Peripheral Nerve Disorders
- Literary and Cultural Studies
- Frailty in Older Adults
- Eosinophilic Disorders and Syndromes
Columbia University
2024
Icahn School of Medicine at Mount Sinai
2024
Instituto Nacional de Cancerología
2013-2024
University of Chicago
2022-2024
Complejo Hospitalario de Jaén
2016-2023
Neurological Surgery
2023
Asepeyo Hospital Sant Cugat
2023
Hospital Regional Universitario de Málaga
2020
Brigham and Women's Hospital
2019
Harvard University
2019
Abstract MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect each single gene generally modest, and therapeutically negligible. Here we describe module microRNAs, constituted by miR-124, miR-128 miR-137, which are co-expressed during neuronal differentiation simultaneously lost in gliomagenesis. Each one these miRs targets several transcriptional regulators, including oncogenic chromatin repressors EZH2, BMI1 LSD1, functionally interdependent involved...
In Brief Study Design. Experimental dog model of acute spinal cord injury. Objective. To compare the relative value methylprednisolone, surgical decompression, or both for treatment traumatic Summary Background Data. Acute injury results from primary damage to at time initial as well a deleterious secondary cascade events, which leads further damage. Surgical decompression is known improve clinical outcomes, but timing remains controversial. Methods. A nylon tie was used constrict in 18...
The safety and effectiveness of task-sharing (TS) in neurosurgery, delegating clinical roles to non-neurosurgeons, is not well understood. This study evaluated an ongoing TS model the Philippines, where neurosurgical workforce deficits are compounded with a large neurotrauma burden.Medical records from emergency admissions 2 hospitals were reviewed (January 2015-June 2018): Bicol Medical Center (BMC), government hospital which neurosurgery chiefly performed by general surgery residents (TS...
Abstract Objectives To investigate resistance-associated substitutions (RASs) as well retreatment efficacies in a large cohort of European patients with failure glecaprevir/pibrentasvir. Methods Patients were identified from three Resistance Reference centres Spain, Italy and Germany. Sequencing NS3, NS5A NS5B was conducted associated resistance to direct antiviral agents analysed. Clinical virological parameters documented retrospectively evaluated. Results We evaluated 90...
In recent years, frailty indices such as the 11- and 5-factor modified (mFI-11 mFI-5), American Society of Anesthesiologists (ASA) physical status classification, Charlson Comorbidity Index (CCI) have been shown to be effective predictors various postoperative outcomes in neurosurgical patients. The Hospital Frailty Risk Score (HFRS) is a well-validated tool for assessing frailty; however, its utility has not evaluated intracranial tumor surgery. present study, authors investigated accuracy...
OBJECTIVE Chordomas are rare malignant bone tumors whose location in the skull base or spine, invasive surgical treatment, and accompanying adjuvant radiotherapy may all lead patients to experience poor quality of life (QOL). Limited research has been conducted on specific demographic clinical factors associated with decreased QOL chordoma survivors. Thus, aim present study was investigate several potential variables their impact domains these as well frequencies challenges within domains....
Chordomas are a rare form of aggressive bone cancer and associated with poor quality life (QOL). The present study sought to characterize demographic clinical characteristics QOL in chordoma co-survivors (caregivers patients chordoma) assess whether access care for challenges. Chordoma Foundation Survivorship Survey was electronically distributed co-survivors. questions assessed emotional/cognitive social QOL, significant challenges being defined as experiencing ≥5 within either these...
Abstract Background Health disparities have been highlighted among patient with prostate adenocarcinoma (PRAD) due to ethnicity. Mexican men present a more aggressive disease than other patients resulting in less favorable treatment outcome. We aimed identify the mutational landscape which could help reduce health minority groups and generate first genomics exploratory study of PRAD patients. Methods Paraffin-embedded formalin-fixed tumoral tissue from 20 early-stage treated at The Instituto...
Health disparities have been highlighted among patient with prostate adenocarcinoma (PRAD) due to ethnicity. Mexican men present a more aggressive disease than other patients resulting in less favorable treatment outcome. We aimed identify the mutational landscape which could help reduce health minority groups and generate first genomics exploratory study of PRAD patients.
e18032 Background: All patients diagnosed of advanced or relapsed squamous cell carcinoma head and neck (SCCHN) are relapsing before a platin-based first line therapy, then, median overall survival with treatment options available till 2016 is around 6 months. Since CheckMate 141 results, we have evidence nivolumab activity in this scenario. Methods: We performed retrospective observational study, including all recurrent SCCHN treated our institution (tertiary center Spain) compassionate use...
e21521 Background: In our institution, median age of patients with lung cancer is 71. We decide to study how are treated over 80 years. Methods: performed a retrospective observational study, including all elderly referred Medical Oncology in institution (tertiary center Spain) 5-year period (2010 2014), and followed until June 2015. The inclusion criteria an years or older at the time diagnosis cancer. cohort 48 Results: Most patients, 77.1 % were male, average 81 (80-87). They represent 6%...
e15548 Background: TGCT is the most common malignant solid neoplasm in young men. Those with advanced disease have survival rates between 40 to 80%, 30% will relapse. Treatment and prognostic facto...
e15546 Background: Testicular germ-cell tumor (TGCT) is the most frequent solid neoplasm in young adults. Current guidelines recommend that CS IS patients should be treated with cisplatin-based chemotherapy (CT). Long-term adverse events such as infertility and cardiovascular disease are well known. Methods: We retrospectively reviewed clinical charts from TGCT our institution january 2000 to december 2012. were identified, treatment type patterns of recurrence registered. Prognostic factors...
4555 Background: Cisplatin-based chemotherapy cures over 80% of testicular germ cell tumors (TGCTs); nucleotide-excision repair (NER) modifies the sensitivity to cisplatin. In this work we explored association between NER-proteins and their polymorphisms (SNPs) with cisplatin-sensitivity (CPS) overall survival (OS) patients advanced non-seminomatous (ns)-TGCTs treated bleomycin-etoposide-cisplatin (BEP). Methods: ERCC1, XPA-expression gammaH2AX-presence, were tested in cisplatin-treated...
Objective: Surgery is the most common treatment for symptomatic pituitary adenomas (PAs). Although it has been shown that surgery performed at high-volume facilities (HVFs) are associated with better outcomes, use of such hospitals may not be equitably distributed. In this study, authors set out to evaluate racial and socioeconomic differences in access PA United States.