A5078764650- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Curcumin's Biomedical Applications
- Lipid metabolism and disorders
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Trace Elements in Health
- Cardiac Ischemia and Reperfusion
- Biomarkers in Disease Mechanisms
- Vitamin D Research Studies
Clinica Universidad de Navarra
2021-2024
University of the Basque Country
2021
Abstract Background Obesity-associated dysfunctional intestinal permeability contributes to systemic chronic inflammation leading the development of metabolic diseases. The inflammasomes constitute essential components in regulation homeostasis. We aimed determine impact gut barrier dysfunction and context obesity type 2 diabetes (T2D). Methods Blood samples obtained from 80 volunteers ( n = 20 normal weight, 21 OB without T2D, 39 with T2D) a subgroup jejunum were used case–control study....
Inflammasomes maintain tissue homeostasis and their altered regulation in the colon, adipose (AT) leads to chronic activation of inflammatory pathways promoting colon cancer (CC) development. We aimed analyze potential involvement inflammasomes obesity-associated CC.Ninety-nine volunteers [61 with obesity (OB) 38 normoponderal (NP)] further subclassified according approved protocol for diagnosis CC (58 without 41 CC) were included case-control study.CC (P<0.01) accompanied by increased mRNA...
Abstract INTRODUCTION Lower limb ischemia-reperfusion injury (IRI-LL) is a common major complication in orthopaedic surgery, especially elderly patients. We previously demonstrated that folic acid reduced IRI-LL damage 3–4-month-old rats. Current work analyses the effect of prevention animals. MATERIAL AND METHODS Thirty-six 12-month-old male WAG/RijHsd rats were subjected to 3 hours ischaemia. Eighteen animals received (2.5 mg/kg, ip) 20 minutes before end ischaemia period; other half same...
Abstract INTRODUCTION Some plant-based antioxidants, such as curcumin, have shown anti-tumour properties against breast carcinomas and gliomas. The aim of this piece work is to assess the effect curcumin on CC531 colorectal cancer cells, both in vitro vivo. MATERIAL AND METHODS On cultures, cell viability was analysed, well migration capacity (wound healing test), 24, 48 72 hours after treatment with (15, 20, 25 or 30 µM). Additionally, WAG/RijHsd rats bearing CC531-induced liver implants,...