A5006973395- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Parasitic Diseases Research and Treatment
- Trypanosoma species research and implications
- Parasites and Host Interactions
- HIV/AIDS Research and Interventions
- Dermatological diseases and infestations
- Research on Leishmaniasis Studies
- Migration, Health and Trauma
- Poverty, Education, and Child Welfare
- HIV-related health complications and treatments
- Child Nutrition and Water Access
- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Helminth infection and control
- Complement system in diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Adolescent Sexual and Reproductive Health
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- HIV/AIDS Impact and Responses
- Cervical Cancer and HPV Research
Universitat de Barcelona
2016-2025
Barcelona Institute for Global Health
2016-2025
University Hospital of Bern
2022
Harvard University
2022
Gobierno de Navarra
2022
Hospital Clínic de Barcelona
2018
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2014-2016
We estimated healthcare costs associated with patients type 2 diabetes compared non-diabetic subjects in a population-based primary care database through retrospective analysis of economic impact during 2011, including 126,811 Catalonia, Spain. Total annual included visits, hospitalizations, referrals, diagnostic tests, self-monitoring test strips, medication, and dialysis. For each patient, one control matched for age, gender managing physician was randomly selected from population...
Abstract Background Residual malaria transmission is the result of adaptive mosquito behavior that allows vectors to thrive and sustain in presence good access bed nets or insecticide residual spraying. These behaviors include crepuscular outdoor feeding as well intermittent upon livestock. Ivermectin a broadly used antiparasitic drug kills mosquitoes on treated subject for dose-dependent period. Mass administration with ivermectin has been proposed complementary strategy reduce...
Purpose To explore the relationship between chronic kidney disease (CKD) and diabetic retinopathy (DR) in a representative population of type 2 diabetes mellitus (DM2) patients Catalonia (Spain). Methods This was population-based, cross-sectional study. A total 28,344 diagnosed with DM2 who had recorded ophthalmologic renal functional examinations were evaluated. Data obtained from primary healthcare electronic database medical records. CKD defined as an estimated glomerular filtration ratio...
Benznidazole is one of the two most effective antiparasitic drugs for Chagas' disease treatment. However, knowledge about its toxicity profile mostly based on post-marketing observational studies. Our study combines data from prospective clinical trials designed to assess safety drug newly produced by ELEA Laboratories (Abarax®). Eligible participants were selected using a consecutive sampling strategy in CINEBENZ and BIOMARCHA studies between 2013 2016 (EUDRACT 2011-002900-34...
The COVID-19 pandemic and the widespread associated use of non-pharmaceutical interventions have impacted viral circulation incidence respiratory tract infections. We compared Pediatric Emergency Department visits, bronchiolitis admissions, syncytial virus (RSV) cases in 2020 with those documented for preceding four years. This was a retrospective multicentric national survey study, driven by Spanish Society, gathering monthly data from hospitals between 1st January 2016 31st December 2020....
Older subjects with type 2 diabetes mellitus (T2DM) have differential characteristics compared middle-aged or younger populations, and require tailored management of the disease.To evaluate how clinical characteristics, degree control glycaemia cardiovascular risk factors, presence chronic complications treatments differ between older T2DM patients adults.Cross-sectional study using data from a population-based electronic database. We retrieved 318,020 ≥ 30 years diagnosed T2DM, attended...
<h3>Background/aims</h3> Retinal photography with a non-mydriatic camera is the method currently employed for diabetic retinography (DR) screening. We designed this study in order to evaluate prevalence and severity of DR, associated risk factors, patients type 2 diabetes (T2DM) screened Catalan Primary Health Care. <h3>Methods</h3> Retrospective, cross-sectional, population based performed Catalonia (Spain) T2DM, aged between 30 years 90 (on 31 December 2012) retinal whose DR category was...
Our objectives were to compare effectiveness and long-term prognosis after epicardial thoracoscopic atrial fibrillation (AF) ablation vs. endocardial catheter ablation, in patients with prior failed or high risk of failure. Patients randomized consisting pulmonary vein isolation optional additional lines (2007–2010). reassessed 2016/2017, those without documented AF recurrence underwent 7-day ambulatory electrocardiography. The primary rhythm outcome was any arrhythmia lasting >30 s....
Abstract Background Attaining the goal of reducing global malaria burden is threatened by recent setbacks in maintaining effectiveness vector control interventions partly due to emergence pyrethroid resistant vectors. One potential strategy address these could be combining indoor residual spraying (IRS) with non-pyrethroids and standard insecticide-treated nets (ITNs). This study aimed provide evidence on incremental epidemiological benefit using third-generation IRS product a highly endemic...
The objective of this cross-sectional study was to assess differences in the control and treatment modifiable cardiovascular risk factors (CVRF: HbA1c, blood pressure [BP], LDL-cholesterol, body mass index, smoking habit) according gender presence disease (CVD) patients with type 2 diabetes mellitus (T2DM) Catalonia, Spain. included available data from electronic medical records for a total 286,791 patients. After controlling sex, age, duration, received, both men women prior CVD had worse...
In Mozambique, there is limited data regarding the monitoring of Tuberculosis (TB) treatment results and determinants adverse outcomes under routine surveillance conditions. The objectives this study were to evaluate among TB patients, analyze factors associated with a fatal outcome determine proportion deaths attributable in district Manhiça, Southern Mozambique.This retrospective observational based on patients diagnosed period 2011-2012. We used three different sources: a) related...
Although the burden of postdischarge mortality (PDM) in low-income settings appears to be significant, no clear recommendations have been proposed relation follow-up care after hospitalization. We aimed determine pediatric PDM and develop predictive models identify children who are at risk for dying discharge.Deaths hospital discharge among aged <15 years last 17 were reviewed an area under demographic morbidity surveillance Southern Mozambique. determined over time (up 90 days) derived...
Ivermectin is a widely used antiparasitic drug with known efficacy against several single-strain RNA viruses. Recent data shows significant reduction of SARS-CoV-2 replication in vitro by ivermectin concentrations not achievable safe doses orally. Inhaled therapy has been success for other antiparasitics. An ethanol-based formulation was administered once to 14 rats using nebulizer capable delivering particles alveolar deposition. Rats were randomly assigned into three target dosing groups,...
Abstract Background: There are major shortfalls in the identification and screening of at-risk migrant groups. This study aims to evaluate effectiveness a new digital tool (IS-MiHealth) integrated into electronic patient record system primary care centres detecting prevalent infections. IS-MiHealth provides targeted recommendations health professionals for multiple infections, including HIV, hepatitis B C, active tuberculosis, Chagas disease, strongyloidiasis, schistosomiasis, based on...
Chagas disease, caused by the parasite Trypanosoma cruzi, is neglected tropical disease with a highest burden in Latin America. Its acute stage mostly asymptomatic and goes unnoticed. Symptoms appear at chronic stage, which when diagnosis usually made. This based on agreement of two conventional serological tests such as Enzyme-Linked Immunosorbent Assays (ELISAs). There are commercial kits good sensitivity specificity but their use impractical many highly endemic regions poorly equipped...
Background The Lihir Islands of Papua New Guinea, located in an area with high burden malaria and hosting a large mining operation, offer unique opportunity to study transmission. There, we investigated human vector factors influencing Methods In 2019, cross-sectional was conducted on 2,914 individuals assessing prevalence through rapid diagnostic tests (RDT), microscopy, quantitative PCR (qPCR). A logistic regression analysis identified infection-associated factors. Anopheles species...
Malaria presents a disproportionate threat to pregnant women, making access malaria prevention tools crucial for controlling the disease in this vulnerable population. This prospective descriptive study targeted women of reproductive age (13–49 years old) living Mopeia district, high endemic area Zambezia province, Mozambique. As part BOHEMIA cluster randomized trial, included simplified and full census collect data on socio-demographic, socio-economic household factors, health status, from...
Abstract Background Headlice are prevalent worldwide, with a higher burden in rural, lower-middle income settings. They can cause intense itchiness, discomfort, and secondary bacterial infections potentially serious consequences. Ivermectin is efficacious against headlice, also being evaluated as malaria vector control tool. In this study, we explored risk factors for assessed the efficacy of ivermectin mass drug administration (MDA) designed headlice. Methods We conducted an open-label,...
BackgroundVertical transmission of Trypanosoma cruzi represents approximately 20% new Chagas disease cases. Early detection and treatment for women childbearing age newborns is a public health priority, but the lack simple reliable diagnostic test remains major barrier. We aimed to evaluate performance point-of-care loop-mediated isothermal amplification (LAMP) assay T cruzi.MethodsIn this proof-of-concept study, we coupled low-cost 3D printer repurposed sample preparation (PrintrLab) Eiken...
Acute HIV infection (AHI) is the period prior to seroconversion characterized by high viral replication, hyper-transmission potential and commonly, non-specific febrile illness. AHI detection requires HIV-RNA load (VL) determination, which has very limited access in low-income countries due restrictive costs implementation constraints. We sought identify a biomarker that could enable diagnosis scarce-resource settings, evaluate feasibility of its implementation. HIV-seronegative adults...
Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted Mozambique prior first round vaccine demonstration programme. It targeted girls aged 10–19 years old identified from schools households. Face-to-face structured interviews were conducted. A total 1147 adolescents enrolled three selected districts country. Most [84%...