A5043356424- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Liver Disease Diagnosis and Treatment
- Innovations in Medical Education
- T-cell and B-cell Immunology
- Diphtheria, Corynebacterium, and Tetanus
- Clostridium difficile and Clostridium perfringens research
- Global Health Workforce Issues
- Adolescent Sexual and Reproductive Health
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Viral Infections and Outbreaks Research
- HIV/AIDS Impact and Responses
- Diversity and Career in Medicine
The University of Western Australia
2016-2023
North Metropolitan Health Service
2023
The burden of HIV is especially concerning for Eastern and Southern Africa (ESA), as despite expansion test-and-treat programmes, this region continues to experience significant challenges resulting from high rates morbidity, mortality new infections. Hard-won lessons programmes on the ground in ESA should be shared.This report summarises relevant evidence regional experts' recommendations regarding specific ESA.This commentary includes an in-depth review literature, progress against global...
During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells the immune system show altered frequencies signs extensive activation. These changes have been shown to relevant role in predicting disease progression; however, challenges identifying PHI resulted lack critical information about dynamics early pathogenic events. We studied soluble biomarkers T-cell subsets individuals at (n=40), Chronic (CHI, n=56) HIV-uninfected (n=58)...
Introduction Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage biological functions, especially in immune system. Previous studies been limited by difficulties obtaining specimens. Methods A hospital symptom-based screening approach was applied a rural Mozambican setting enrol patients with suspected acute (Fiebig stage I-IV). Blood samples were collected all those recruited, so that cases...
Acute HIV infection (AHI) is the period prior to seroconversion characterized by high viral replication, hyper-transmission potential and commonly, non-specific febrile illness. AHI detection requires HIV-RNA load (VL) determination, which has very limited access in low-income countries due restrictive costs implementation constraints. We sought identify a biomarker that could enable diagnosis scarce-resource settings, evaluate feasibility of its implementation. HIV-seronegative adults...
During acute HIV infection, actively replicates but seroconversion has not yet occurred. Primary infection (PHI) is characterized by a transient nonspecific febrile illness, massive inflammatory response, and the progressive appearance of anti-HIV-specific antibodies. In this study, we have identified patterns biomarkers associated with innate immunological reaction before completion full humoral response.A symptom-based screening was used to identify in Manhiça District Hospital Mozambique....
Abstract Background Diphtheria caused by toxin‐producing Corynebacterium ulcerans is a re‐emerging human disease that can cause local and systemic sequelae. In Australia, toxigenic diphtheria rare notifiable communicable disease, due to high‐vaccination coverage. The public health management of cutaneous cases C. varies between jurisdictions, as opposed the more uniform response diphtheriae presenting respiratory or laryngeal diphtheria. Aim To report case zoonotically acquired , review...
Acute human immunodeficiency virus (HIV) infection (AHI) refers to the period between viral transmission and development of an adaptive immune response HIV antigens (seroconversion) usually lasting 6–8 weeks. Rare cases have been described in which HIV-infected patients fail seroconvert instead, develop rapid HIV-mediated clinical decline. We report case a Mozambican woman with AHI malaria coinfection who showed atypical seroconversion experienced deterioration death within 14 weeks...
Primary HIV infection (PHI) and subsequent chronic alter B-cell compartment. However, longitudinal analysis defining the dynamics of alterations are still limited. We longitudinally studied subsets in individuals followed for 1 year after PHI (n = 40). Treated untreated infected 56) HIV-uninfected 58) were recruited as reference groups at Manhiça District Mozambique. B cells analyzed by multicolor flow-cytometry. Anti-HIV humoral response plasma cytokines assessed ELISA or Luminex-based...