A5029611097- Biochemical Acid Research Studies
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Fatty Acid Research and Health
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Colorectal Cancer Screening and Detection
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Esophageal Cancer Research and Treatment
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Biosimilars and Bioanalytical Methods
- Simulation-Based Education in Healthcare
Navarrabiomed
2023-2025
Navarre Institute of Health Research
2023-2025
Universidad Michoacana de San Nicolás de Hidalgo
2024
Clinica Universidad de Navarra
2011-2023
Universidad de Navarra
2011-2021
University of Pamplona
2018
Objective To evaluate the potential body weight-lowering effects of dietary supplementation with eicosapentaenoic acid (EPA) and α-lipoic separately or combined in healthy overweight/obese women following a hypocaloric diet. Methods This is short-term double-blind placebo-controlled study parallel design that lasted 10 weeks. Of randomized participants, 97 received allocated treatment [Control, EPA (1.3 g/d), (0.3 + g/d 0.3 g/d)], 77 volunteers completed study. All groups followed an...
The neutrophil-to-lymphocyte ratio has demonstrated to be a prognostic inflammatory marker in cardiovascular disease. objective of this study is evaluate the association between and pathologic urinary albumin/creatinine as an early risk systemic endothelial dysfunction, associated with microvascular disease, asymptomatic subjects.A unicenter cross-sectional was conducted, including 1816 subjects. Patients previous those who were treated ACE inhibitors and/or angiotensin II receptor blockers...
Cystatin C has been shown to be associated with heart failure preserved ejection fraction (HFPEF). In addition, myocardial fibrosis involved in diastolic dysfunction HFPEF. Therefore, we hypothesized that increased cystatin levels may altered collagen metabolism, contributing patients HFPEF.One hundred and forty-one elderly hypertensive HFPEF were included. Cardiac morphology function was assessed by echocardiography. Circulating of C, biomarkers type I synthesis (carboxy-terminal propeptide...
The neutrophil-to-lymphocyte ratio has demonstrated to be a prognostic inflammatory marker in cardiovascular disease. objective of this study is evaluate the association between neutrophil–lymphocyte and pathologic urinary albumin/creatinine as an early risk systemic endothelial dysfunction, associated with microvascular disease, asymptomatic subjects. A unicenter cross-sectional was conducted, including 1816 Patients previous those who were treated ACE inhibitors and/or angiotensin II...
In obesity, the increment of adiposity levels disrupts whole body homeostasis, promoting an over production oxidants and inflammatory mediators. The current study aimed to characterize transcriptomic changes promoted by supplementation with eicosapentaenoic acid (EPA, 1.3 g/day), α-lipoic (0.3 or both (EPA + acid, g/day 0.3 g/day) in subcutaneous abdominal adipose tissue from overweight/obese healthy women, who followed a hypocaloric diet (30% total energy expenditure) during ten weeks,...
Eicosapentaenoic acid (EPA) and α-lipoic (α-LA) have been investigated for their beneficial effects on obesity cardiovascular risk factors. In the current research, goal was to evaluate metabolomic changes following dietary supplementation of these two lipids, alone or combined in healthy overweight/obese sedentary women an energy-restricted diet. For this purpose, untargeted metabolomics approach conducted urine samples using liquid chromatography coupled with time flight mass spectrometry...
Abstract Pancreatic ductal adenocarcinoma represents one of the solid tumors showing worst prognosis worldwide, with a high recurrence rate after adjuvant or neoadjuvant therapy. Circulating tumor DNA analysis raised as promising non-invasive tool to characterize genomics and assess treatment response. In this study, surgical tissue sequential blood samples were analyzed by next-generation sequencing correlated clinical pathological characteristics. Thirty resectable/borderline pancreatic...
EPA and LIP supplementation regulate the serum fatty acid profile. also modulates FGF21 level.
Abstract Introduction Metabolic syndrome (MetS), prediabetes (PreDM) and Fatty Liver Disease (FLD) share pathophysiological pathways concerning type 2 diabetes mellitus (T2DM) onset. The non‐invasive assessment of fatty liver combined with PreDM MetS features screening might provide further accuracy in predicting hyperglycemic status the clinical setting putative description singular phenotypes. objective study is to evaluate describe links a widely available FLD surrogate ‐the serological...
Cardiotrophin (CT)-1 is a regulator of glucose and lipid homeostasis. In the present study, we analyzed whether CT-1 also acts to peripherally regulate metabolic rhythms adipose tissue core clock genes in mice. Moreover, circadian pattern plasma levels was evaluated normal-weight overweight subjects. The rhythmicity oxygen consumption rate (VO2) disrupted aged obese CT-1-deficient (CT-1−/−) mice (12 mo). Although VO2 were conserved young lean CT-1−/− (2 mo), deficiency caused phase shift...
Abstract Intermediate care units (ImCUs) have been shown as appropriate for the management of selected septic patients. Developing specific protocols residents in training may be useful their medical performance. The objective this study was to analyze whether a simulation-based learning bundle is while acquiring competencies sepsis during internship an ImCU. A prospective study, set tertiary-care academic center performed enrolling who ImCU from 2014 2017. pillars were scenario simulation...
<title>Abstract</title> <bold>Background.</bold> Pancreatic ductal adenocarcinoma (PDAC) represents one of the worst prognostic cancers worldwide, with a high recurrence rate after adjuvant or neoadjuvant therapy (NAT). Circulating tumor DNA (ctDNA) analysis raised as promising non-invasive tool to characterize genomics and assess treatment response.<bold>Methods.</bold> In this study, surgical tissue sequential blood samples were analyzed by next-generation sequencing correlated clinical...