A5073685728- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Biochemical Acid Research Studies
- Fibroblast Growth Factor Research
- Muscle metabolism and nutrition
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Kruppel-like factors research
- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Dietary Effects on Health
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Neuropeptides and Animal Physiology
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Gut microbiota and health
Universidad de Navarra
2018-2024
The Ohio State University Wexner Medical Center
2022-2024
The Ohio State University
2023-2024
University of Pamplona
2018
Aging entails changes at the cellular level that increase risk of various pathologies. An association between gut microbiota and age-related diseases has also been attributed. This study aims to analyze in fecal composition their with genes related immune response, inflammation, intestinal barrier impairment. Fecal samples female mice different ages (2 months, 6 12 18 months) gene expression colon tissue were analyzed. Results showed older group had a more diverse than younger group....
Brown adipose tissue (BAT) dysfunction in aging and obesity has been related to chronic unresolved inflammation, which could be mediated by an impaired production of specialized proresolving lipid mediators (SPMs), such as Lipoxins-LXs, Resolvins-Rvs, Protectins-PDs, Maresins-MaRs. Our aim was characterize the changes BAT SPMs signatures their association with during aging, especially under obesogenic conditions, modulation a docosahexaenoic acid (DHA)-rich diet. Lipidomic, functional,...
Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation white (WAT) browning.
Obesity and aging are associated to non-alcoholic fatty liver disease (NAFLD) development. Here, we investigate whether long-term feeding with a docosahexaenoic acid (DHA)-enriched diet aerobic exercise, alone or in combination, effective ameliorating NAFLD aged obese mice. Two-month-old female C57BL/6J mice received control high fat (HFD) for 4 months. Then, the diet-induced (DIO) were distributed into four groups: DIO, DIO + DHA (15% dietary lipids replaced by DHA-rich concentrate), EX...
Resistance training (RT) and n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation have emerged as strategies to improve muscle function in older adults. Overweight/obese postmenopausal women (55–70 years) were randomly allocated one of four experimental groups, receiving placebo (olive oil) or docosahexaenoic acid (DHA)-rich PUFA alone combination with a supervised RT-program for 16 weeks. At baseline at end the trial, body composition, anthropometrical measures, blood pressure serum...
Obesity exacerbates aging-induced adipose tissue dysfunction. This study aimed to investigate the effects of long-term exercise on inguinal white (iWAT) and interscapular brown (iBAT) aged obese mice. Two-month-old female mice received a high-fat diet for 4 months. Then, six-month-old diet-induced animals were allocated sedentarism (DIO) or treadmill training (DIOEX) up 18 months age. In exercised mice, iWAT depot revealed more adaptability, with an increase in expression fatty acid...
Abstract Sirtuins 1 (SIRT1) and Forkhead box protein O1 (FOXO1) expression have been associated with obesity metabolic dysfunction-associated steatotic liver disease (MASLD). Exercise and/or docosahexaenoic acid (DHA) supplementation shown beneficial effects on MASLD. The current study aims to assess the relationships between Sirt1 , Foxo1 mRNA levels several MASLD biomarkers, as well of DHA-rich n-3 PUFA exercise in aged obese female mice, peripheral blood mononuclear cells (PBMCs)...
EPA and LIP supplementation regulate the serum fatty acid profile. also modulates FGF21 level.
Obesity is increasing at epidemic rates across the US and worldwide, as are its co-morbidities, including type-2 diabetes cardiovascular disease. Thus, targeted interventions to reduce prevalence of obesity utmost importance. The sigma-1 receptor (S1R) sigma-2 (S2R; encoded by Tmem97) belong same class drug-binding sites, yet they genetically distinct. There multiple ongoing clinical trials focused on sigma receptors, targeting diseases ranging from Alzheimer’s disease through chronic pain...
This study aimed to characterize the potential beneficial effects of chronic docosahexaenoic acid (DHA) supplementation on restoring subcutaneous white adipose tissue (scWAT) plasticity in obese aged female mice. Two-month-old C57BL/6J mice received a control (CT) or high fat diet (HFD) for 4 months. Then, 6-month-old diet-induced (DIO) were distributed into DIO and DIOMEG group (fed with DHA-enriched HFD) up 18 In scWAT, reduced mean adipocyte size reversed upregulation lipogenic genes...
Obesity and aging promote chronic low-grade systemic inflammation. The aim of the study was to analyze effects long-term physical exercise and/or omega-3 fatty acid Docosahexaenoic (DHA) supplementation on genes or proteins related muscle metabolism, inflammation, damage/regeneration myokine expression in aged obese mice. Two-month-old C57BL/6J female mice received a control high-fat diet for 4 months. Then, diet-induced (DIO) were distributed into four groups: DIO, DIO + DHA, EX (treadmill...
The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease offspring. Maternal exercise prevents detrimental effects maternal high fat diet on metabolic health adult offspring, but offspring have not been thoroughly investigated. To determine health, female mice were fed chow (C; 21% kcal from fat) or high-fat (H; 60% further subdivided into sedentary (CS, HS) wheel exercised (CW, HW) prior to throughout gestation....
Obesity is characterized by excessive fat accumulation and inflammation. Aging has also been as an inflammatory condition, frequently accompanied of visceral fat. Beneficial effects exercise n-3 long-chain polyunsaturated fatty acids in metabolic disorders have described. Glucose transporter 12 (GLUT12) one the less investigated members GLUT family. Glucose, insulin, tumor necrosis factor alpha (TNF-α) induce GLUT12 translocation to membrane muscle, adipose tissue, intestine. We aimed...
Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its comorbidities. One of the processes involved in aging is cellular senescence, which highly dependent on activity regulators cell cycle. The aim this study was to analyze changes expression p27 cdk2 different adipose tissue depots during aging, as well their regulation by mice. Changes CDK2 subcutaneous white (WAT) biopsies were also analyzed a human cohort type 2...
The prevalence of metabolic diseases is rapidly increasing and a principal contributor to this diet, including increased consumption energy-rich foods with added phosphates. Exercise an effective therapeutic approach combat disease. While exercise the detrimental effects high-fat diet on health, high-phosphate have not been thoroughly investigated. Here, we investigated or in presence absence voluntary function male mice. To do this, mice were fed low-fat, normal-phosphate (LFPD), (HPD)...