A5016827168- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Mesenchymal stem cell research
- Genomics and Chromatin Dynamics
- Birth, Development, and Health
- Histone Deacetylase Inhibitors Research
- High Altitude and Hypoxia
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Cardiovascular Disease and Adiposity
- Gestational Diabetes Research and Management
- RNA Research and Splicing
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Sleep and related disorders
- Neonatal Respiratory Health Research
- Thermal Regulation in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2025
Hospital Universitari Arnau de Vilanova
2022-2025
Instituto de Salud Carlos III
2022-2025
Biomedical Research Institute of Lleida
2022-2025
Universidad de Oviedo
2016-2023
Biomedical Research and Innovation Institute of Cadiz
2019-2023
Biomedical Research Institute
2021
Universidad de Cádiz
2019-2020
Central University Hospital of Asturias
2019
Nanomaterials and Nanotechnology Research Center
2017-2018
Actigraphy devices are used in sleep medicine. The Actiwatch 2 (Philips Respironics) was an example of a frequently device this field. Nevertheless, the discontinuation has led to increased necessity for implementation other available actigraphy methods capable providing objective information. study assess performance new ActTrust compared model.
Circulating cell-free microRNAs (miRNAs) are promising biomarkers for medical decision-making. Suitable endogenous controls essential to ensure reproducibility. We aimed identify and validate reference miRNAs qPCR data normalization in samples from SARS-CoV-2-infected hospitalized patients. used plasma (n = 170) COVID-19 patients collected at hospital admission (COVID-Ponent project, www.clinicaltrials.gov/NCT04824677). First, 179 were profiled using RT–qPCR. After stability assessment,...
There is a limited understanding of the pathophysiology postacute pulmonary sequelae in severe COVID-19. The aim current study was to define circulating microRNA (miRNA) profiles associated with function and radiologic features survivors SARS-CoV-2-induced ARDS. included patients who developed ARDS secondary SARS-CoV-2 infection (n = 167) group infected did not develop 33). Patients were evaluated 3 months after hospital discharge. follow-up complete evaluation chest computed tomography....
Abstract Background and Purpose The post‐acute sequelae of SARS‐CoV‐2 infection pose a significant global challenge, with nearly 50% critical COVID‐19 survivors manifesting persistent lung abnormalities. lack understanding about the molecular mechanisms effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher systemic underpinnings pulmonary complications. Experimental Approach We conducted longitudinal investigation including 119 survivors. A...
Lipoproteins have been described as microRNAs (miRNAs) carriers. Unfortunately, the bibliography on this topic is scarce and shows a high variability between independent investigations. In addition, miRNA profiles of LDL VLDL fractions not completely elucidated. Here, we profiled human circulating lipoprotein-carried miRNome. Lipoprotein (VLDL, HDL) were isolated from serum healthy subjects by ultracentrifugation purified size-exclusion chromatography. A panel 179 miRNAs commonly expressed...
Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark might also play a role process. Here, we analyzed genome-wide profile 5hmc mesenchymal stem cells (MSCs) obtained from bone-marrow donors, aged 2–89 years. We identified 10,685 frequently hydroxymethylated CpG sites MSCs were, as other cell types, significantly associated with low density...
The identification of critically ill COVID-19 patients at risk fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in patients. Second, constructed blood miRNA classifier the early prediction adverse ICU.This was multicenter, observational and retrospective/prospective study including 503 admitted to ICU from 19 hospitals. qPCR assays were performed plasma samples collected within 48 h upon admission. A 16-miRNA...
Aberrant DNA hypermethylation is a hallmark of cancer although the underlying molecular mechanisms are still poorly understood. To study possible role 5-hydroxymethylcytosine (5hmC) in this process we analyzed global and locus-specific genome-wide levels 5hmC 5-methylcytosine (5mC) human primary samples from 12 non-tumoral brains 53 gliomas. We found that identified were significantly reduced Strikingly, hypo-hydroxymethylation at 4627 (9.3%) CpG sites was associated with aberrant strongly...
Obesity is one of the main causes chronic kidney disease; however, precise molecular mechanisms leading to onset injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed unveil microRNA (miRNA) expression profile a model obesity-induced disease C57BL/6J mice using next-generation sequencing (NGS) analysis. High-fat diet (HFD)-induced obesity led notable structural alterations tubular glomerular regions kidney, increased renal proinflammatory...
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, though it known to be essential for embryonic development, its role during adult life still poorly understood. Here we show that this lysine massively hyperacetylated peripheral neutrophils. Genome-wide mapping of H4K16ac terminally differentiated blood cells, along with functional experiments, supported histone post-translational modification the...
Abstract Dilated cardiomyopathy (DCM) is the third most common cause of heart failure. The multidisciplinary nature testing — involving genetics, imaging, or cardiovascular techniques makes its diagnosis challenging. Novel and reliable biomarkers are needed for early identification tailored personalized management. Peripheral circular RNAs (circRNAs), a leading research topic, remain mostly unexplored in DCM. We aimed to assess whether peripheral circRNAs expressed differentially among...
Abstract The left ventricular (LV) ejection fraction (EF) is key to prognosis in dilated cardiomyopathy (DCM). Circulating microRNAs have emerged as reliable biomarkers for heart diseases, included DCM. Clinicians need improved tools greater clarification of DCM EF categorization, identify high-risk patients. Thus, we investigated whether microRNA profiles can categorize patients based on their EF. 179-differentially expressed circulating were screened two groups: (1) non-idiopathic DCM; (2)...
Patients with heart failure reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes.To test whether the circulating miRNome provides additional information for stratification on top clinical predictors in patients HFrEF CSA.The study included CSA from SERVE-HF trial. A three-step protocol was applied: microRNA (miRNA) screening (n = 20), technical validation 60), biological 587). The primary outcome either death any cause, lifesaving...
Bronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.To identify the proteomic determinants associated with disease pathogenesis, all-cause mortality respiratory sequelae in BAS samples from critically ill patients SARS-CoV-2-induced ARDS.Multicenter study including 74 COVID-19 non-COVID-19 ARDS. were by bronchoaspiration after IMV initiation. Three hundred sixty-four proteins quantified using...
Abstract Breast and prostate cancers have been associated with circadian disruption. Some previous studies examined associations of sleep duration breast or cancer risk though findings remain inconsistent. This study examines a range detailed characteristics in large-scale population-based case–control study, MCC-Spain. A total 1738 incident cases, 1112 cases frequency matched controls (n = 1910, 1493 respectively) were recruited. Detailed data on habitual duration, quality, timing, daytime...
Up to 80% of patients surviving acute respiratory distress syndrome (ARDS) secondary SARS-CoV-2 infection present persistent anomalies in pulmonary function after hospital discharge. There is a limited understanding the mechanistic pathways linked post-acute sequelae. To identify molecular underpinnings associated with severe lung diffusion involvement survivors SARS-CoV-2-induced ARDS. Survivors attended complete evaluation 3 months RNA sequencing (RNA-seq) was performed using Illumina...