Alberto Gómez‐Carballa
A5045076168- Forensic and Genetic Research
- Respiratory viral infections research
- Genetic diversity and population structure
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Phylogenetic Studies
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Animal Virus Infections Studies
- RNA modifications and cancer
- Neonatal and Maternal Infections
- Race, Genetics, and Society
- Archaeology and ancient environmental studies
- Sepsis Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- interferon and immune responses
- Plant Virus Research Studies
- Tracheal and airway disorders
- Food Allergy and Anaphylaxis Research
- Vaccine Coverage and Hesitancy
- Emergency and Acute Care Studies
- Streptococcal Infections and Treatments
- Kawasaki Disease and Coronary Complications
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2025
Instituto de Investigación Sanitaria de Santiago
2016-2025
Servicio Gallego de Salud
2017-2025
Universidade de Santiago de Compostela
2016-2025
Instituto de Salud Carlos III
2022-2024
Complejo Hospitalario Universitario de Santiago
2015-2023
Imperial College London
2023
National and Kapodistrian University of Athens
2023
Comunidad de Madrid
2022
Centro de Investigación Biomédica en Red
2022
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only three, plus IFN-ω five, and IFN-α2, IFN-β two; nine patients). Seven (3.8%) Abs at least ng/ml one IFN, whereas the other 12 (6.6%) 100 pg/ml. The auto-Abs neutralized both unglycosylated glycosylated IFNs. also detected pg/ml 4 2,267 uninfected (0.2%) 45 (2%). odds ratios (ORs) life-threatening were, therefore,...
It is now widely agreed that the Native American founders originated from a Beringian source population ~15-18 thousand years ago (kya) and rapidly populated all of New World, probably mainly following Pacific coastal route. However, details about migration into Americas routes pursued on continent still remain unresolved, despite numerous genetic, archaeological, linguistic investigations. To examine pioneering peopling phase South continent, we screened literature mtDNA databases...
Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages geographical distributions that indicative an early arrival from Beringia with Paleo-Indians. In contrast, the estimated C1d--the third subset C1--looked too young to fit above scenario. To define origin this enigmatic branch, we completely sequenced 63 C1d genomes a wide range geographically diverse, mixed, indigenous American...
The human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the major pandemic of twenty-first century. We analyzed more than 4700 SARS-CoV-2 genomes and associated metadata retrieved from public repositories. sequences have a high sequence identity (>99.9%), which drops to >96% when compared bat genome. built mutation-annotated reference phylogeny with two main macro-haplogroups, A B, both Asian origin, 160 sub-branches representing virus strains...
<sec><title>Background</title> Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, patients, with the aim characterizing their monocyte-macrophage disease To best our knowledge, this is first study its kind. </sec><sec><title>Methods</title> Fifty-nine SARS-Cov-2 positive hospitalized classified according to ICU or non-ICU admission requirement, were prospectively recruited...
Host genetics is a key determinant of COVID-19 outcomes. Previously, the Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with However, largest impact on outcomes are expected be rare in population. Hence, studying may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome whole-genome sequencing from 21 cohorts across 12 countries performed...
Background Sepsis is defined as dysregulated host response to infection that leads life-threatening organ dysfunction. Biomarkers characterising the in sepsis are lacking. We aimed develop gene expression signatures predict dysfunction children with bacterial or viral infection. Methods This cohort study was done emergency departments and intensive care units of four hospitals Queensland, Australia, recruited aged 1 month 17 years who, upon admission, underwent a diagnostic test, including...
With analyses of entire mitogenomes, studies Native American mitochondrial DNA (mtDNA) variation have entered the final phase phylogenetic refinement: dissection founding haplogroups into clades that arose in America during and after human arrival spread. Ages geographic distributions these could provide novel clues on colonization processes different regions double continent. As for Southern Cone South America, this approach has recently allowed identification two local (D1g D1j) whose age...
Significance Ancient DNA has revolutionized the field of archaeology, but in Caribbean and other tropical regions world, work been hampered by poor preservation. We present an ancient human genome from use it to shed light on early peopling islands. demonstrate that ancestors so-called “Taino” who inhabited large parts pre-Columbian times originated northern South America, we find evidence they had a comparatively effective population size. also show native components some modern genomes are...
Molecular techniques can often reveal a broader range of pathogens in respiratory infections. We aim to investigate the prevalence and age pattern viral co-infection children hospitalized with lower tract acute infection (LT-ARI), using molecular techniques.A nested polymerase chain reaction approach was used detect Influenza (A, B), metapneumovirus, syncytial virus (RSV), parainfluenza (1-4), rhinovirus, adenovirus (A-F), bocavirus coronaviruses (NL63, 229E, OC43) samples prospectively...
Recent and compelling archaeological evidence attests to human presence ∼14.5 ka at multiple sites in South America a very early exploitation of extreme high-altitude Andean environments. Considering that, according genetic evidence, entry into North from Beringia most likely occurred ∼16 ka, these archeological findings would imply an extremely rapid spread along the double continent. To shed light on this issue perspective, we first completely sequenced 217 novel modern mitogenomes Native...
Background Multiple viruses are often detected in children with respiratory infection but the significance of co-infection pathogenesis, severity and outcome is unclear. Objectives To correlate presence viral clinical phenotype admitted acute infections (ARI). Methods We collected detailed information on for ARI as part a Spanish prospective multicenter study (GENDRES network) between 2011–2013. A nested polymerase chain reaction (PCR) approach was used to detect secretions. Findings were...
The recently enriched genomic history of Indigenous groups in the Americas is still meager concerning continental Central America. Here, we report ten pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven presently living Panama. Our analyses reveal that demographic events contributed to extensive genetic structure currently seen area, which also characterized by a distinctive Isthmo-Colombian component. This component drives these populations on specific...
Coronavirus Disease-19 (COVID-19) symptoms range from mild to severe illness; the cause for this differential response infection remains unknown. Unravelling immune mechanisms acting at different levels of colonization process might be key understand these differences. We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis immune-related genes patients affected by COVID-19 severities, healthy controls through nCounter technology. Mild asymptomatic cases...
The genetic background of Argentineans is a mosaic different continental ancestries. From colonial to present times, the contribution Europeans and sub-Saharan Africans has superposed or replaced indigenous 'stratum'. A sample 384 individuals representing Argentinean provinces was collected genotyped for first second mitochondrial DNA (mtDNA) hypervariable regions, selectively mtDNA SNPs. This data analyzed together with additional 440 profiles from rural urban populations plus 304 Native...
Mitochondrial DNA (mtDNA) lineages of macro-haplogroup L (excluding the derived L3 branches M and N) represent majority typical sub-Saharan mtDNA variability. In Europe, these mtDNAs account for <1% total but, when analyzed at level control region, they show no signals having evolved within European continent, an observation that is compatible with a recent arrival from African continent. To further evaluate this issue, we 69 mitochondrial genomes belonging to various sublineages wide...
Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by Andes Amazon rainforest. The interactions between these paths their impact on peopling remain unclear. Analysis genetic variation in Peruvian regions located south River might provide clues this issue. We analyzed mitochondrial DNA at different Andean locations >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate trans-Andean...
Background and Aims A properly validated scoring system allowing objective categorization of infants with acute respiratory infections (ARIs), avoiding the need for in-person assessment that could also be used by non-health professionals is currently not available. We aimed to develop a new clinical scale meeting these specifications. Methods designed (ReSVinet scale) based on seven parameters (feeding intolerance, medical intervention, difficulty, frequency, apnoea, general condition,...
Abstract Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning and disease, as well severity. We performed RNA Sequencing of individuals varying degrees COVID-19 used differential expression analysis pathway enrichment explore how transcriptome differs between mild, moderate, severe COVID-19, performing...
Only a few genetic studies have been carried out to date in Bolivia. However, some of the most important (pre)historical enclaves South America were located these territories. Thus, (sub)-Andean region Bolivia was part Inca Empire, largest state Pre-Columbian America. We genotyped first hypervariable (HVS-I) 720 samples representing main regions Bolivia, and data analyzed context other pan-American (>19,000 HVS-I mtDNAs). Entire mtDNA genome sequencing also undertaken on selected Native...
Abstract Rare mitochondrial lineages with relict distributions can sometimes be disproportionately informative about deep events in human prehistory. We have studied one such lineage, haplogroup R0a, which uniquely is most frequent Arabia and the Horn of Africa, but distributed much more widely, from Europe to India. conclude that: (1) lineage ancestral R0a ancient than previously thought, a distribution across Mediterranean/Southwest Asia; (2) has deeper presence highlighting role at least...