A5052120847- Endometrial and Cervical Cancer Treatments
- Aquaculture disease management and microbiota
- Cancer Genomics and Diagnostics
- Homotopy and Cohomology in Algebraic Topology
- Cancer Cells and Metastasis
- Genetic diversity and population structure
- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Advanced Topics in Algebra
- Genetic and phenotypic traits in livestock
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Algebraic structures and combinatorial models
- Forensic and Genetic Research
- Invertebrate Immune Response Mechanisms
- interferon and immune responses
- Marine Bivalve and Aquaculture Studies
- melanin and skin pigmentation
- Parasite Biology and Host Interactions
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Research and Treatments
- Bacillus and Francisella bacterial research
- Fish Ecology and Management Studies
- Angiogenesis and VEGF in Cancer
- Parasites and Host Interactions
- Mycobacterium research and diagnosis
Universidade de Santiago de Compostela
2015-2024
Xunta de Galicia
2018
Roslin Institute
2018
University of Edinburgh
2018
Lund University
2012
Government of Extremadura
2003-2005
The turbot is a flatfish (Pleuronectiformes) with increasing commercial value, which has prompted active genomic research aimed at more efficient selection. Here we present the sequence and annotation of genome, represents milestone for both boosting breeding programmes ascertaining origin diversification flatfish. We compare genome model fish genomes to investigate teleost chromosome evolution. observe conserved macrosyntenic pattern within Percomorpha identify large syntenic blocks related...
The 11-M Madrid commuter train bombings of 2004 constituted the second biggest terrorist attack to occur in Europe after Lockerbie, while subsequent investigation became most complex and wide-ranging forensic case Spain. Standard short tandem repeat (STR) profiling 600 exhibits left certain key incriminatory samples unmatched any apprehended suspects. A judicial order perform analyses differentiate European North African ancestry a critical part was instigated help refine search for further...
Metastatic colorectal cancer (mCRC) relies on the detachment of aggressive malignant cells from primary tumor into bloodstream and, concordantly, presence these Circulating Tumor Cells (CTC) is associated with a poor prognosis. In this work, molecular characterization CTC mCRC patients was approached, aim understanding their biology and improving clinical utility in management patients. For this, EpCAM-based immunoisolation combined whole transcriptome amplification hybridization onto cDNA...
Understanding sex determination (SD) across taxa is a major challenge for evolutionary biology. The new genomic tools are paving the way to identify features underlying SD in fish, group frequently showing limited chromosome differentiation and high turnover. Turbot (Scophthalmus maximus) commercially important flatfish with an undifferentiated ZW/ZZ system remarkable sexual dimorphism. Here we describe long-read turbot genome assembly used disentangle genetic architecture of by combining...
Forensic age estimation is a DNA intelligence tool that forms an important part of Phenotyping. Criminal cases with no suspects or unsuccessful matches in searches on databases; human identification analyses mass disasters; anthropological studies legal disputes; all benefit from to gain investigative leads. Several prediction models have been developed date based methylation. Although different methylation technologies as well diverse statistical methods proposed, most them are blood...
Circulating tumor cells (CTCs), proposed as major players in cancer dissemination, have demonstrated clinical prognostic significance several types. However, their predictive value remains unclear. Here we evaluated the utility of six CTC markers (tissue specific and epithelial to mesenchymal transition transcripts) both tools metastatic colorectal (mCRC) patients. CTCs were immunoisolated from blood 50 mCRC patients at baseline 4 16 weeks after treatment onset. Expression levels GAPDH,...
Purpose: Endometrial cancer (EC) diagnosis relies on the observation of tumor cells in endometrial biopsies obtained by aspiration (i.e., uterine aspirates), but it is associated with 22% undiagnosed patients and up to 50% incorrectly assigned EC histotype grade. We aimed identify biomarker signatures fluid fraction these overcome limitations.Experimental Design: The levels 52 proteins were measured aspirates from 116 LC-PRM, latest generation targeted mass-spectrometry acquisition. A...
Individual age estimation can be applied to criminal, legal, and anthropological investigations. DNA methylation has been established as the biomarker of choice for prediction, since it was observed that specific CpG positions in genome show systematic changes during an individual's lifetime, with progressive increases or decreases levels. Subsequently, several forensic prediction models have reported, providing average error ranges ±3-4 years, using a broad spectrum technologies underlying...
Age estimation based on epigenetic markers is a DNA intelligence tool with the potential to provide relevant information for criminal investigations, as well improve inference of age-dependent physical characteristics such male pattern baldness or hair color. prediction models have been developed different tissues, including saliva and buccal cells, which show methylation patterns they are composed cell populations. On many occasions in investigation, origin sample proportion tissues not...
DNA methylation has become a biomarker of great interest in the forensic and clinical fields. In criminal investigations, study this epigenetic marker allowed development intelligence tools providing information that can be useful for investigators, such as age prediction. Following similar trend, when origin sample scenario is unknown, inference an individual's lifestyle tobacco use alcohol consumption could provide relevant to help identification donors at crime scene. At same time,...
The turbot (Scophthalmus maximus; Scophthalmidae; Pleuronectiformes) is a flatfish species of great relevance for marine aquaculture in Europe. In contrast to other cultured flatfish, very few genomic resources are available this species. Aeromonas salmonicida and Philasterides dicentrarchi two pathogens that affect culture causing serious economic losses the industry. Little known about molecular mechanisms disease resistance host-pathogen interactions work, thousands ESTs functional...
Abstract Background Genomic resources for plant and animal species that are under exploitation primarily human consumption increasingly important, among other things, understanding physiological processes establishing adequate genetic selection programs. Current available techniques high-throughput sequencing have been implemented in a number of species, including fish, to obtain proper description the transcriptome. The objective this study was generate comprehensive transcriptomic database...
Abstract Background The turbot ( Scophthalmus maximus ) is a relevant species in European aquaculture. small genome provides source for genomics strategies to use order understand the genetic basis of productive traits, particularly those related sex, growth and pathogen resistance. Genetic maps represent essential genomic screening tools allowing localize quantitative trait loci (QTL) identify candidate genes through comparative mapping. This information backbone develop marker-assisted...