A5072816401- SARS-CoV-2 and COVID-19 Research
- Microbial Community Ecology and Physiology
- BRCA gene mutations in cancer
- Ion channel regulation and function
- Algal biology and biofuel production
- COVID-19 Clinical Research Studies
- Effects and risks of endocrine disrupting chemicals
- Photosynthetic Processes and Mechanisms
- Arsenic contamination and mitigation
- Wastewater Treatment and Nitrogen Removal
- Genetic Associations and Epidemiology
- PARP inhibition in cancer therapy
- Diabetes and associated disorders
- Child Abuse and Trauma
- Marine and coastal ecosystems
- Immune Cell Function and Interaction
- Child and Adolescent Psychosocial and Emotional Development
- Protist diversity and phylogeny
- vaccines and immunoinformatics approaches
- Heavy Metal Exposure and Toxicity
- Biocrusts and Microbial Ecology
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Cancer Genomics and Diagnostics
- Heavy metals in environment
University of Nevada, Reno
2010-2025
Renown Health
2024-2025
Helix (United States)
2024
Desert Research Institute
2016-2023
Genomic Health (United States)
2022
It is increasingly recognized that SARS-CoV-2 can produce long-term complications after recovery from the acute effects of infection. Here, we report analysis 32 self-reported short and symptoms in a general adult population cohort comprised 357 COVID-19+ cases, 5,497 SARS-CoV-2-negative controls, 19,095 non-tested individuals. The majority our cases are mild, with only 9 having been hospitalized. Our results show 36.1% have lasting longer than 30 days, 14.8% still at least one symptom 90...
Host genetics is a key determinant of COVID-19 outcomes. Previously, the Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with However, largest impact on outcomes are expected be rare in population. Hence, studying may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome whole-genome sequencing from 21 cohorts across 12 countries performed...
COVID-19 vaccines are safe and highly effective, but some individuals experience unpleasant reactions to vaccination. As the majority of adults in United States have received a vaccine this year, there is an unprecedented opportunity study genetics vaccination via surveys who already part genetic research studies. Here, we queried 17,440 participants Helix DNA Discovery Project Healthy Nevada about their Our genome-wide association identifies between severe difficulties with daily routine...
This study aimed to evaluate the performance of different genetic screening approaches identify women at high risk breast cancer in general population.
Chronic exposure to high levels of arsenic in drinking water can have wide-ranging health effects and is a global concern. The domestic well population the western Great Basin (WGB) at increased risk due hydrologic, geologic, climatic setting region. A logistic regression (LR) model was developed predict probability elevated (≥5 μg/L) alluvial aquifers assess potential geologic hazard level posed populations. Alluvial are susceptible contamination, which concern because they primary source...
Respiratory ammonification and denitrification are two evolutionarily unrelated dissimilatory nitrogen (N) processes central to the global N cycle, activity of which is thought be controlled by carbon (C) nitrate (NO3-) ratio. Here we find that Intrasporangium calvum C5, a novel dual-pathway denitrifier/respiratory ammonifier, disproportionately utilizes rather than when grown under low C concentrations, even at C:NO3- ratios. This finding in conflict with paradigm high ratios promote...
Background: Interventions are needed to help people reduce exposure harmful chemicals from everyday products and lifestyle habits. Report-back of individual exposures is a potential pathway increasing environmental health literacy (EHL) readiness exposures. Objectives: Our objective was determine if report-back endocrine-disrupting (EDCs) can EDC exposure, increase EHL, change (i.e., implement exposure-reduction behaviors). Methods: Participants in the Healthy Nevada Project completed EHL...
Background: Daily-use products, including personal care household and dietary supplements, often contain ingredients that raise concerns regarding harmful chemical exposure. Endocrine-disrupting chemicals (EDCs) found in daily-use products are associated with numerous adverse health effects. Methods: This pilot study explores the relationship between concentrations of EDCs urine samples used 24 h prior to sample collection, concern those 140 adults reproductive age Northern Nevada. Results:...
Prochlorococcus is a globally abundant marine cyanobacterium with many adaptations that reduce cellular nutrient requirements, facilitating growth in its nutrient-poor environment. One such genomic adaptation the preferential utilization of amino acids containing fewer N-atoms, which minimizes nitrogen requirements. We predicted transcriptional regulation might further N budgets during transient limitation. To explore this, we compared transcription start sites (TSSs) MED4 under N-deprived...
Adverse Childhood Experiences are stressful and traumatic events occurring before the age of eighteen shown to cause mental physical health problems, including increased risk obesity. Obesity remains an ongoing national challenge with no predicted solution. We examine a subset Healthy Nevada Project, focusing on multi-ethnic cohort 15,886 sequenced participants recalled adverse childhood events, study how ACEs their genotype-environment interactions affect BMI. Specifically, Project by Helix...
Importance Most patients with pathogenic or likely (P/LP) variants for breast cancer have not undergone genetic testing. Objective To identify meeting family history criteria testing in the electronic health record (EHR). Design, Setting, and Participants This study included both cross-sectional (observation date, February 1, 2024) retrospective cohort period, January 2018, to analyses. aged 18 79 years enrolled Renown Health, a large system Northern Nevada. Genotype was known 38 003 Healthy...
With some exceptions, the deep fractured rock ecosystems across most of North America have not been studied extensively. However, US Great Basin, in particular Nevada National Security Site (NNSS, formerly Test Site), has hosted a number influential subsurface investigations over years. This study focuses on resident microbiota within fluids extracted from monitoring borehole U-3cn#5 at depth 691 meters below land surface, which intercepts hydrogeological confined aquifer Paleozoic carbonate...
As complex mental health traits and life histories are often poorly captured in hospital systems, the utility of using Barratt Impulsivity Scale (BIS) Adverse Childhood Experiences (ACEs) for assessing adult disease risks is unknown. Here, we use participants from Healthy Nevada Project (HNP) to determine if two standard self-assessments could predict incidence onset disease. We conducted a retrospective cohort study involving who completed Behavioral Mental Health Self-Assessment (HDSA)...
The purpose of this study was to determine whether extracellular matrix (ECM) composition through integrin receptors modulated the volume-sensitive osmolyte anion channels (VSOACs) in skeletal muscle-derived C2C12 cells. Cl(-) currents were recorded whole cell voltage-clamped cells grown on laminin (LM), fibronectin (FN), or absence a defined ECM (NM). Basal membrane isotonic media (300 mosmol/kg) larger FN (3.8-fold at +100 mV) LM (8.8-fold when compared with NM. VSOAC activated by exposure...
The clinical value of population-based genetic screening projects depends on the actions taken findings. Healthy Nevada Project (HNP) is an all-comer and research project based in northern Nevada. HNP participants with CDC Tier 1 findings hereditary breast ovarian cancer syndrome (HBOC), Lynch (LS), or familial hypercholesterolemia (FH) are notified provided counseling. However, subsequently takes a "hands-off" approach: it responsibility to share their healthcare providers, providers...
In this research, we examine and identify the implications of Adverse Childhood Experiences (ACEs) on a range health outcomes, with particular focus number mental disorders. Many previous studies observed that traumatic childhood events are linked to long-term adult diseases using standard Experience Questionnaire. The study cohort was derived from Healthy Nevada Project, volunteer-based population in which each participant is invited take retrospective questionnaire includes Questionnaire,...
Abstract Purpose In the United States, breast cancer clinical risk assessments are inconsistent and inequitable. The previous success of BRCA1 BRCA2 screening has demonstrated that genetics could be used to reduce these inequities, if they available accessible across population. aim this study is evaluate performance different genetic approaches identify women at high-risk in general Methods We did a retrospective on 25,591 participating Healthy Nevada Project. Electronic Health Records...
Abstract Human genetic studies of critical COVID-19 pneumonia have revealed the essential role type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between HLA-B*15:01 allele and asymptomatic infection in unvaccinated individuals was recently reported, suggesting a contribution pre-existing T cell-dependent adaptive immunity. We report lack classical HLA alleles, including HLA-B*15:01, with pre-omicron participants prospective population-based study...
To test the hypothesis that chloride channel ClC‐3 comprises a key component of native volume‐sensitive outwardly rectifying anion channels (VSOAC) in mammalian heart and further assess its physiological role cardiac function, we generated cardiac‐specific Clcn3 knockout (KO) mice, utilizing heart‐specific α‐myosin heavy chain (α‐MHC) promoter Cre/Lox technology. Examination properties VSOACs isolated KO atrial myocytes revealed two groups cells: group 1 myocytes, VSOAC current densities...
Abstract Host genetics is a key determinant of COVID-19 outcomes. Previously, the Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with However, largest impact on outcomes are expected be rare in population. Hence, studying may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome whole-genome sequencing from 21 cohorts across 12 countries...
Exposures to endocrine disrupting chemicals (EDCs) have been linked chronic diseases including breast cancer, metabolic syndrome, diabetes, and infertility. Exposure during pregnancy may a lifelong impact on the fetus. Services are needed allow individuals learn about their personal EDC exposures how reduce them. Million Marker (MM) aims crowdsource scale biomonitoring of environmental provide actionable results empower proactively assess, track, exposures. In previous research, we developed...