Carmen Rodríguez‐Tenreiro
A5102937841- Respiratory viral infections research
- Proteins in Food Systems
- Pneumonia and Respiratory Infections
- Drug Solubulity and Delivery Systems
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Polysaccharides Composition and Applications
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Advanced Drug Delivery Systems
- Microencapsulation and Drying Processes
- Neonatal and Maternal Infections
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Tracheal and airway disorders
- Crystallization and Solubility Studies
- Streptococcal Infections and Treatments
- Kawasaki Disease and Coronary Complications
- Protein Hydrolysis and Bioactive Peptides
- Protein purification and stability
- Ethics in Clinical Research
- Animal Virus Infections Studies
Complejo Hospitalario Universitario de Santiago
2015-2025
Instituto de Investigación Sanitaria de Santiago
2015-2025
Instituto de Salud Carlos III
2022-2025
Universidade de Santiago de Compostela
2006-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2025
Servicio Gallego de Salud
2020-2025
Patan Academy of Health Sciences
2023
Imperial College London
2023
Sotiria General Hospital
2023
National and Kapodistrian University of Athens
2023
<sec><title>Background</title> Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, patients, with the aim characterizing their monocyte-macrophage disease To best our knowledge, this is first study its kind. </sec><sec><title>Methods</title> Fifty-nine SARS-Cov-2 positive hospitalized classified according to ICU or non-ICU admission requirement, were prospectively recruited...
Background Sepsis is defined as dysregulated host response to infection that leads life-threatening organ dysfunction. Biomarkers characterising the in sepsis are lacking. We aimed develop gene expression signatures predict dysfunction children with bacterial or viral infection. Methods This cohort study was done emergency departments and intensive care units of four hospitals Queensland, Australia, recruited aged 1 month 17 years who, upon admission, underwent a diagnostic test, including...
Abstract Background The morbidity burden of respiratory syncytial virus (RSV) in infants extends beyond hospitalization. Defining the RSV before implementing prophylaxis programs is essential for evaluating any potential impact on short‐ to mid‐term and utilization primary healthcare (PHC) emergency services (ES). We established this reference data using a population‐based cohort approach. Methods Infants hospitalized from January 2016 March 2023 were matched with non‐hospitalized ones based...
Coronavirus Disease-19 (COVID-19) symptoms range from mild to severe illness; the cause for this differential response infection remains unknown. Unravelling immune mechanisms acting at different levels of colonization process might be key understand these differences. We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis immune-related genes patients affected by COVID-19 severities, healthy controls through nCounter technology. Mild asymptomatic cases...
There are currently no pharmacological therapies to address the intellectual disability associated with Down syndrome. Excitatory/inhibitory imbalance has been hypothesized contribute impairments in cognitive functioning Negative modulation of GABAA-α5 receptor is proposed as a mechanism attenuate GABAergic function and restore excitatory/inhibitory balance.Basmisanil, selective negative allosteric modulator, was evaluated at 120 mg or 240 BID (80 160 for 12-13 years) 6-month, randomized,...
Nirsevimab has been recently licensed for universal RSV prophylaxis in infants. NIRSE-GAL is a three-year population-based study initiated Galicia September 2023. It aims to evaluate nirsevimab effectiveness against RSV-related hospitalizations lower respiratory tract infections (LRTI), severe RSV, all-cause LRTI, and hospitalization. also estimate impact on primary healthcare use the short mid-term, children's wheezing asthma, medical prescriptions RSV. The immunization campaigns will be...
Background and Aims A properly validated scoring system allowing objective categorization of infants with acute respiratory infections (ARIs), avoiding the need for in-person assessment that could also be used by non-health professionals is currently not available. We aimed to develop a new clinical scale meeting these specifications. Methods designed (ReSVinet scale) based on seven parameters (feeding intolerance, medical intervention, difficulty, frequency, apnoea, general condition,...
Abstract Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning and disease, as well severity. We performed RNA Sequencing of individuals varying degrees COVID-19 used differential expression analysis pathway enrichment explore how transcriptome differs between mild, moderate, severe COVID-19, performing...
Rotavirus vaccine (RV) might reduce the risk of hospitalization due to childhood seizures (CS). We aimed identify and assess variations in incidence hospitalizations for CS among children <5 years age before after RV introduction.Annual rates any kind CS, introduction 2007, were calculated using official surveillance system data.Our study cohort totaled 6149 admitted hospital between 2003 2013 with (780.3* + 779.0* 333.2* 345* ICD-9-CM code). The annual correlated coverage (r = -0.673; P...
Human respiratory syncytial virus (RSV) is a major cause of lower tract infection in young children globally, but little known about within-host RSV diversity. Here, we characterised populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had consensus diversity than RSV-A at the population level, while exhibiting greater Two sequences an amino acid alteration (K68N) fusion (F) protein, which has been associated with reduced susceptibility to...
Research on the effectiveness of COVID-19 booster-based vaccine schedule is ongoing and real-world data (VE) in comorbid patients are limited. We aimed to estimate booster dose VE against SARS-CoV-2 infection severity general population patients. A retrospective test-negative control study was undertaken Galicia-Spain (December 2020–November 2021). 95% confidence interval (CI) were estimated using multivariate logistic regression models. 1,512,415 (94.13%) negative 94,334 (5.87%) positive...
Abstract Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants young children worldwide. Here we evaluated host demographic viral factors associated with RSV disease severity 325 RSV-infected under 1 year of age from 3 European countries during 2017–2020. Younger had a higher clinical (ReSViNET) score were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older (&lt;3 months vs &lt;6 ≥6...
Abstract Flow properties at pH 5.5‐7.5 of whey protein isolate (WPI)‐xanthan solutions containing 0‐0.5 w/w% xanthan were studied by viscosimetry, although rigidity and fracture the corresponding heat‐set gels (90°C, 30 min) determined uniaxial compression. All displayed generalized shearthinning flow behaviour. Synergistic WPI‐xanthan interactions has been revealed observing that rheological parameters [σ msf , K, n, η (γ)] characterizing blends larger than those calculated from two...