A5061841909- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Genetic Syndromes and Imprinting
- Bone Tumor Diagnosis and Treatments
- Neonatal Respiratory Health Research
- Antibiotics Pharmacokinetics and Efficacy
- Central Venous Catheters and Hemodialysis
- Assisted Reproductive Technology and Twin Pregnancy
- Bacterial Identification and Susceptibility Testing
- Bone health and treatments
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Otolaryngology and Infectious Diseases
- Antimicrobial Resistance in Staphylococcus
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Heterotopic Ossification and Related Conditions
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Immunology Research
- Vitamin C and Antioxidants Research
- RNA and protein synthesis mechanisms
Instituto de Investigación Sanitaria de Santiago
2016-2023
Servicio Gallego de Salud
2019-2023
Complejo Hospitalario Universitario de Santiago
2015-2022
Universidade de Santiago de Compostela
2015-2019
Hospital Sant Joan de Déu Barcelona
2013
Improving the quality of hospital antibiotic use is a major goal WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed present data on patterns paediatric AWaRe be used for local national interventions.1-day point prevalence survey prescription were combined from two independent networks: Global Antimicrobial...
Background Multiple viruses are often detected in children with respiratory infection but the significance of co-infection pathogenesis, severity and outcome is unclear. Objectives To correlate presence viral clinical phenotype admitted acute infections (ARI). Methods We collected detailed information on for ARI as part a Spanish prospective multicenter study (GENDRES network) between 2011–2013. A nested polymerase chain reaction (PCR) approach was used to detect secretions. Findings were...
Background and Aims A properly validated scoring system allowing objective categorization of infants with acute respiratory infections (ARIs), avoiding the need for in-person assessment that could also be used by non-health professionals is currently not available. We aimed to develop a new clinical scale meeting these specifications. Methods designed (ReSVinet scale) based on seven parameters (feeding intolerance, medical intervention, difficulty, frequency, apnoea, general condition,...
Background The risk of bacteremia is considered low in children with acute bronchiolitis. However the rate occult infants RSV infection not well established. aim was to determine actual and predictive factors admitted hospital due confirmed respiratory illness (ARI), using both conventional culture molecular techniques. Methods A prospective multicenter study (GENDRES-network) conducted between 2011–2013 under age two because an ARI. Among those RSV-positive, bacterial presence blood...
Abstract Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome host as factor determining susceptibility caused by RSV. We sequenced complete exomes 54 patients infected RSV that needed hospitalization due development severe bronchiolitis. The Iberian sample (IBS) from 1000 Genomes Project (1000G) was used control group; all association results were pseudo-replicated using...
ABSTRACT Background: Vitamin D is known to have modulatory actions in the immune system. Its influence on severity of lower tract acute respiratory infections (LT‐ARIs) unclear. Objectives: The aim present study was evaluate role vitamin LT‐ARI paediatric patients. Methods: Children admitted hospital with were prospectively recruited through GENDRES network (March 2009–May 2013). 25‐hydroxyvitamin (25‐OHD) levels measured by immunoassay. illness evaluated according clinical scales, length...
Abstract Background There is no consensus on how to best quantify disease severity in infants with respiratory syncytial virus (RSV) and/or bronchiolitis; this lack of a sufficiently validated score complicates the provision clinical care and, evaluation trials therapeutics and vaccines. The ReSVinet appears be one most promising; however, it too time consuming incorporated into routine care. We aimed develop externally validate simplified versions score. Methods Data from multinational (the...
The IFI27 interferon gene expression has been found to be largely increased in rotavirus (RV)-infected patients. encodes for a protein of unknown function, very recently linked epidermal proliferation and related the growth factor (EGF) protein. EGF is low-molecular-weight polypeptide that mainly produced by submandibular parotid glands, it plays an important physiological role maintenance oro-esophageal gastric tissue integrity. Our aim was determine salivary levels RV-infected patients...
Central venous catheter (CVC) removal is indicated when persistent catheter-related bloodstream infection (CRBSI) occurs. This a retrospective study to analyze the use of linezolid as salvage therapy for CRBSIs due coagulase-negative Staphylococci in children diagnosed with acute leukemia. Seven treatment courses were administrated six patients port-type-CRBSI after non-effective intravenous vancomycin or teicoplanin treatment. Simultaneous lock and systemic avoided port-type-CVC all cases....
Progressive osseous heteroplasia (POH; OMIM 166350) is a rare autosomal-dominant genetic disorder in which extra-skeletal bone forms within skin and muscle tissue. POH one of the clinical manifestations an inactivating mutation GNAS gene. gene alterations are difficult matter to address, as alleles show imprinting produce several transcript products, same may lead strikingly different phenotypes. Also, most publications concerning patients either depictions case (or series), descriptions...
Progressive osseous heteroplasia (POH) is an ultrarare genetic disorder characterized by inactivating mutation in the GNAS gene that causes heterotopic ossification. Inhibition of mammalian target rapamycin (mTOR) signalling pathway has been proposed as a therapy for progressive bone fibrodysplasia and non-genetic forms heteroplasia. Herein, we describe impact using Everolimus rescue identical twin girl exhibiting aggressive clinical phenotype POH.Clinical evaluation progression disease...