Debby Bogaert
A5023457650- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Bacterial Infections and Vaccines
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Clostridium difficile and Clostridium perfringens research
- Tracheal and airway disorders
- Streptococcal Infections and Treatments
- Blood disorders and treatments
- COVID-19 and healthcare impacts
- Antimicrobial Resistance in Staphylococcus
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- interferon and immune responses
- Ear Surgery and Otitis Media
Centre for Inflammation Research
2017-2025
Wilhelmina Children's Hospital
2016-2025
University of Edinburgh
2016-2025
Queen's Medical Centre
2019-2025
University Medical Center Utrecht
2016-2025
The Queen's Medical Research Institute
2017-2025
Medical Research Council
2017-2024
National Institute for Public Health and the Environment
2014-2024
Sciensano (Belgium)
2024
Johns Hopkins Hospital
2024
On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, failed to neutralize. Titers against boosted third vaccine doses high both vaccinated individuals those Delta. Mutations knock out reduce...
Many bacterial pathogens causing respiratory infections in children are common residents of the tract. Insight into colonization patterns and microbiota stability at a young age might elucidate healthy or susceptible conditions for development disease.To study succession first 2 years life its relation to health characteristics.Upper profiles 60 ages 1.5, 6, 12, 24 months were characterized by 16S-based pyrosequencing. We determined consecutive machine-learning algorithms validated findings...
Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability clear colonization before these appear, suggesting involvement of other mechanisms. We previously reported that intranasal immunization mice with pneumococci confers CD4+ T cell–dependent, antibody- and serotype-independent protection against colonization. Here we show this immunity, rather than preventing initiation carriage, accelerates clearance over several days, accompanied...
The nasopharynx is the ecological niche for many commensal bacteria and potential respiratory or invasive pathogens like Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis. Disturbance of a balanced nasopharyngeal (NP) microbiome might be involved in onset symptomatic infections with these pathogens, which occurs primarily fall winter. It unknown whether seasonal infection patterns are associated concomitant changes NP microbiota. As young children generally prone to...
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections and hospitalizations in infants worldwide. Known risk factors, however, incompletely explain variability RSV disease severity, especially among healthy children. We postulate that severity infection influenced by modulation host immune response local bacterial ecosystem.To assess whether specific nasopharyngeal microbiota (clusters) are associated with distinct transcriptome profiles children...
Abstract The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the delivery gut microbiota, independent antibiotics, postponing routine administration mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. microbiota differs between infants over first year life, showing enrichment Bifidobacterium spp., reduction Enterococcus Klebsiella spp. composition at...
There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence particular is relatively stable worldwide, but the host and bacterial factors that maintain these patterns poorly understood. Given possibility serotype replacement following vaccination against seven clinically important serotypes, it increasingly to understand factors. We hypothesized biochemical structure polysaccharides could influence degree encapsulation different their...
Rationale: Perinatal and postnatal influences are presumed important drivers of the early-life respiratory microbiota composition. We hypothesized that composition development in infancy is affecting stability thereby resistance against tract infections (RTIs) over time.Objectives: To investigate common environmental drivers, including birth mode, feeding type, antibiotic exposure, crowding conditions, relation to maturation stability, consecutive risk RTIs first year life.Methods: In a...
Birth by Caesarian section is associated with short- and long-term respiratory morbidity. We hypothesized that mode of delivery affects the development microbiota, thereby altering its capacity to provide colonization resistance consecutive pathobiont overgrowth infections. Therefore, we longitudinally studied impact on nasopharyngeal microbiota from birth until six months age in a healthy, unselected cohort 102 children (n = 761 samples). Here, show develops within one day variable mixed...
Breastfeeding elicits significant protection against respiratory tract infections in infancy. Modulation of microbiota might be part the natural mechanisms diseases induced by breastfeeding.To study association between breastfeeding and nasopharyngeal microbial communities, including all cultivable noncultivable bacteria.In this observational study, we analyzed infants that had received exclusive (n = 101) formula feeding at age 6 weeks months 16S-based GS-FLX-titanium-pyrosequencing.At...
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral diseases remain poorly characterized. We analyzed plasma samples 471 hospitalized patients recruited through prospective multicenter ISARIC4C study 39 outpatients with mild disease, enabling extensive characterization of across a full spectrum COVID-19 severity. Progressive elevation levels numerous...
The impact of coronavirus disease (COVID-19) on patients with interstitial lung (ILD) has not been established.
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of antimicrobial resistance when administered in the first week life, during assembly phase microbiome. Here, 147 infants born at ≥36 weeks gestational age, requiring broad-spectrum treatment sEONS their life were randomized 1:1:1 to receive three commonly prescribed intravenous antibiotic combinations, namely penicillin + gentamicin,...
Lower respiratory tract infections (LRTIs) are a leading cause of childhood morbidity and mortality. Potentially pathogenic organisms present in the both symptomatic asymptomatic children, but their presence does not necessarily indicate disease. We aimed to assess concordance between upper lower microbiota during LRTIs use nasopharyngeal discriminate from health.First, we did prospective study children aged 4 weeks 5 years who were admitted paediatric intensive care unit (PICU) at...