A5063238290- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Advanced Power Amplifier Design
- Radio Frequency Integrated Circuit Design
- Quantum Information and Cryptography
- Chronic Kidney Disease and Diabetes
- Quantum Mechanics and Applications
- Full-Duplex Wireless Communications
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- PAPR reduction in OFDM
- Neural Networks and Applications
- Renal and related cancers
- Blood Pressure and Hypertension Studies
- Ion Transport and Channel Regulation
- Folate and B Vitamins Research
- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- Cardiovascular Health and Disease Prevention
- Cancer Diagnosis and Treatment
- Mechanical and Optical Resonators
- Amino Acid Enzymes and Metabolism
- Quantum optics and atomic interactions
- Dialysis and Renal Disease Management
- Magnesium in Health and Disease
Biomedical Research Institute of Lleida
2015-2024
University of Duisburg-Essen
2023
Politecnico di Milano
2023
Instituto de Salud Carlos III
2016-2022
University of Westminster
2012-2022
Spanish Clinical Research Network
2018-2022
Oslo University Hospital
2021
Universitat de Lleida
2018
University Clinical Centre Maribor
2018
Hospital Universitari Arnau de Vilanova
2011-2017
Local inflammation is thought to contribute the progression of diabetic nephropathy. The vitamin D receptor (VDR) activator paricalcitol has an antiproteinuric effect in human nephropathy at high doses. We have explored potential anti-inflammatory effects VDR doses that do not modulate proteinuria experimental model gain insights into benefits activators those patients whose decreased by this therapy. calcitriol and on renal function, albuminuria, was a rat diabetes induced streptozotocin....
Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice improve the prediction of incident cardiovascular (CVD), yet most major guidelines do not have a standardized approach for incorporating these into CVD risk prediction. "CKD Patch" is validated method to calibrate predicted from established equations according CKD measures.Utilizing data 4,143,535 adults 35 datasets, we developed several Patches"...
Abstract Aims The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney (CKD) as high very-high CVD risk status regardless other factors like age does not include estimated glomerular filtration rate (eGFR) albuminuria in its algorithms, systemic coronary estimation 2 (SCORE2) older persons (SCORE2-OP), to predict risk. We developed validated an ‘Add-on’ incorporate CKD measures into these using a...
Kidney fibrosis is a highly deleterious process and final manifestation of chronic kidney disease. Alpha-(α)-synuclein (SNCA) an actin-binding neuronal protein with various functions within the brain; however, its role in other tissues unknown. Here, we describe expression SNCA renal epithelial cells demonstrate decrease tubules murine human fibrotic kidneys, as well downregulation proximal tubular (RPTECs) after TGF-β1 treatment. shRNA-mediated knockdown RPTECs results de novo vimentin...
Abstract Background Secondary hyperparathyroidism (SHPT) is a complication of chronic kidney disease (CKD) and associated with changes in calcium phosphate. These related have been increased cardiovascular mortality CKD progression. It not clear whether negative outcomes linked to SHPT are confounded by such factors. The present study was designed assess the possible independent effects [defined as patients excessive parathyroid hormone (PTH) levels or on treatment PTH-reducing agents] risk...
Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation progression of atherosclerosis. Vitamin D has cardioprotective actions, while its deficiency is a risk factor for cardiovascular damage. Our aim was assess basal levels vitamin receptor (VDR) on early related endothelial cell-adhesion-molecule expression, as prerequisites onset Knockdown VDR cells (shVDR) led activation, characterized by upregulation VCAM-1, ICAM-1 IL-6,...
Background: Chronic kidney disease (CKD) is an independent risk factor for atherosclerotic disease. We hypothesized that CKD promotes a proatherogenic lipid profile modifying lipoprotein composition and particle number. Methods: Cross-sectional study in 395 non-diabetic individuals (209 patients 186 controls) without statin therapy. Conventional determinations were combined with advanced profiling by nuclear magnetic resonance, their discrimination ability was assessed machine learning....
Epithelial–mesenchymal transition (EMT) contributes to the progression of renal tubulointerstitial fibrosis. The N-methyl-D-aspartate receptor (NMDAR), which is present in proximal tubular epithelium, a glutamate that acts as calcium channel. Activation NMDAR induces actin rearrangement cells central nervous system, but whether it helps maintain epithelial phenotype tubule unknown. Here, knockdown NMDAR1 cell line (HK-2) induced changes morphology, reduced E-cadherin expression, and...
There is growing evidence suggesting that phosphate intake associated with blood pressure levels. However, data from epidemiological studies show inconsistent results.The present study was designed to evaluate the effect of high circulating phosphorus on arterial healthy rats and elucidate potential mechanism stands behind this effect. Animals fed a diet for 4 weeks showed an increase in pressure, which returned normal values after addition binder (lanthanum carbonate) diet. The expression...
Vascular calcification (VC) is a complication of chronic kidney disease that predicts morbidity and mortality. Uremic serum promotes VC, but the mechanism involved unknown. A role for 1,25(OH)2 D3 in VC has been proposed, unclear because both low high levels have shown to increase it. In this work we investigate produced vascular smooth muscle cells (VSMCs) VC. Rats with subtotal nephrectomy recipient patients showed increased arterial expression 1α-hydroxylase vivo. VSMCs exposed vitro...
Abstract Controlling cholesterol levels is a major challenge in human health, since hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target carbohydrate metabolism also modify lipid and hence plasma levels. In this sense, dichloroacetate (DCA), pyruvate dehydrogenase kinase (PDK) inhibitor, augments usage of the glycolysis-produced mitochondria increasing oxidative phosphorylation (OXPHOS). several animal models, DCA decreases triglycerides. Thus, was used 70 s...
BACKGROUND: Vascular calcification (VC) is a highly prevalent complication of chronic kidney disease (CKD) and associated with the higher morbidity-mortality patients CKD. VDR (vitamin D receptor) has been proposed to play role in osteoblastic differentiation vascular smooth muscle cells (VSMCs), but involvement vitamin VC CKD controversial. Our aim was determine local signaling VSMCs during CKD-induced VC. METHODS: We used epigastric arteries from CKD-affected individuals normal renal...
Obesity is one of the main causes chronic kidney disease; however, precise molecular mechanisms leading to onset injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed unveil microRNA (miRNA) expression profile a model obesity-induced disease C57BL/6J mice using next-generation sequencing (NGS) analysis. High-fat diet (HFD)-induced obesity led notable structural alterations tubular glomerular regions kidney, increased renal proinflammatory...
Classical risk factors of atherosclerosis in the general population show paradoxical effects chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with worse cardiovascular outcomes. Magnesium (Mg) is a divalent cation whose homeostasis altered CKD. Furthermore, Mg health. The present study aims to understand relationships and lipid parameters In this analysis, 1754 participants from Observatorio Nacional de Atherosclerosis en...