A5082799464- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Renal and Vascular Pathologies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Potassium and Related Disorders
- Erythropoietin and Anemia Treatment
- Alcohol Consumption and Health Effects
- Iron Metabolism and Disorders
- Chronic Disease Management Strategies
- Liver Disease and Transplantation
- Complement system in diseases
- Long-Term Effects of COVID-19
- Diet and metabolism studies
- Frailty in Older Adults
University of Manchester
2019-2025
Salford Royal Hospital
2019-2025
Northern Health and Social Care Trust
2022-2025
Manchester Academic Health Science Centre
2019-2025
Salford Royal NHS Foundation Trust
2015-2024
National Health Service
2024
Royal North Shore Hospital
2024
The University of Sydney
2024
Mercer University Health Sciences Center
2023
Lancashire Teaching Hospitals NHS Foundation Trust
2018-2021
Abstract Background and Aims What is the relationship between blood tests for iron deficiency, including anaemia, response to intravenous in patients with heart failure? Methods In IRONMAN trial, 1137 failure, ejection fraction ≤ 45%, either serum ferritin < 100 µg/L or transferrin saturation (TSAT) 20% were randomized ferric derisomaltose (FDI) usual care. Relationships investigated baseline anaemia severity, TSAT, changes haemoglobin from 4 months, Minnesota Living Heart Failure...
There is a need for more observational studies across different clinical settings to better understand the epidemiology of novel COVID-19 infection. Evidence on characteristics infection scarce in secondary care Western populations.We describe all consecutive positive patients (n = 215) admitted acute medical unit at Fairfield General Hospital (secondary setting) between 23 March 2020 and 30 April based outcome discharge (group 1: alive or group 2: deceased). We investigated risk factors...
Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice improve the prediction of incident cardiovascular (CVD), yet most major guidelines do not have a standardized approach for incorporating these into CVD risk prediction. "CKD Patch" is validated method to calibrate predicted from established equations according CKD measures.Utilizing data 4,143,535 adults 35 datasets, we developed several Patches"...
Abstract Aims The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney (CKD) as high very-high CVD risk status regardless other factors like age does not include estimated glomerular filtration rate (eGFR) albuminuria in its algorithms, systemic coronary estimation 2 (SCORE2) older persons (SCORE2-OP), to predict risk. We developed validated an ‘Add-on’ incorporate CKD measures into these using a...
Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor associated with cardiovascular (CVD) and incidence of chronic kidney (CKD). NAFLD threatening to become a major public health problem in association the metabolic syndrome. The outcomes patients advanced CKD has not been evaluated. In this study, prevalence its impact on renal mortality were determined large secondary care cohort.The study was conducted 1148 within cohort 3061 patients, who had undergone ultrasound...
Chronic kidney disease (CKD) increases risk of cardiovascular (CVD). Less is known about how CVD associates with future failure replacement therapy (KFRT).
Emerging evidence and perspectives have pointed towards the heart playing an important role in hepatorenal syndrome (HRS), outside of conventional understanding that liver cirrhosis is traditionally considered sole origin a cascade pathophysiological mechanisms directly affecting kidneys this context. In absence established disease, cirrhotic cardiomyopathy may occur more frequently those with kidney disease. It specific form cardiac dysfunction characterized by blunted contractile...
Abstract Background and objectives Atherosclerotic renal artery stenosis may cause hypertension, chronic kidney disease heart failure, but large randomized control trials to date have shown no major additional benefit of revascularization over optimal medical management. However, these did not consider outcomes specifically in relation clinical presentations. Given that atherosclerotic is a heterogenous condition, measures success likely differ according the presentation. Our retrospective...
Background: Emerging evidence suggests cell exfoliation could be operating under the control of metabolism. It is unclear if there are associations between concentration exfoliated kidney proximal tubule cells (PTCs) in urine with glycemic and complications. Our study aimed at exploring this. Methods: Urine samples were collected from 122 adult participants stored −80°C. Exfoliated PTCs extracted thawed using a validated specific immunomagnetic separation method based on anti‐CD13...
Nonattendance for prescribed hemodialysis (HD) sessions is a form of nonadherence that compromises the delivery life-sustaining HD therapy and associated with severe morbidity mortality. In this study, we aimed to assess characteristics outcomes nonattenders in single renal center North West England. patients followed by team at our unit between December 2020 September 2022 were included study. Dialysis nonattendance data retrieved from incident reports (DATIX) November 2022, excluding...
BACKGROUND Malnutrition among patients admitted to a pediatric intensive care unit (PICU) is common. However, there lack of data on its impact the critically ill. AIM To assess nutritional status outcome ill children PICU. METHODS This observational study was conducted in tertiary teaching institute for one year, including 210 aged 1 month 14 years 15-bed PICU minimum 24 hours. Patients with less than hours stay, who received palliative care, or syndromic short stature were excluded....
Abstract Background Risk factors predictive of rapid linear chronic kidney disease (CKD) progression and its associations with end-stage renal (ESRD) mortality requires further exploration, particularly as patients estimated glomerular filtration rate (eGFR) trajectory represent a clear paradigm for understanding true CKD progression. Methods A regression slope was applied to all outpatient eGFR values in the Salford Kidney Study who had ≥2 years follow-up, ≥4 baseline stages 3a-4. An...