A5078267586- Urological Disorders and Treatments
- Mast cells and histamine
- Asthma and respiratory diseases
- Genital Health and Disease
- Male Reproductive Health Studies
- Urologic and reproductive health conditions
- Prostate Cancer Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Diversity and Career in Medicine
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Cancer, Stress, Anesthesia, and Immune Response
- Pelvic and Acetabular Injuries
- Urinary and Genital Oncology Studies
- Pelvic floor disorders treatments
- Neuropeptides and Animal Physiology
- Intraocular Surgery and Lenses
- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Hemoglobinopathies and Related Disorders
- Abdominal Trauma and Injuries
- Urinary Tract Infections Management
- Cultural Heritage Management and Preservation
- Trauma and Emergency Care Studies
Penn State Milton S. Hershey Medical Center
2016-2025
Urology of Virginia
2024
Pennsylvania State University
2020-2023
Creative Commons
2023
Collaborative Research Group
2022
GTx (United States)
2022
Tufts University
2021
Cincinnati Eye Institute
2020
American Society of Colon and Rectal Surgeons
2020
American Society of Cataract and Refractive Surgery
2020
Controlled clinical trials of health care interventions are either explanatory or pragmatic. Explanatory test whether an intervention is efficacious; that is, it can have a beneficial effect in ideal situation. Pragmatic measure effectiveness; they the degree real practice. In pragmatic trials, balance between external validity (generalizability results) and internal (reliability accuracy needs to be achieved. The trial seeks maximize by assuring rigorous control all variables other than...
Abstract Background and Aims What is the relationship between blood tests for iron deficiency, including anaemia, response to intravenous in patients with heart failure? Methods In IRONMAN trial, 1137 failure, ejection fraction ≤ 45%, either serum ferritin < 100 µg/L or transferrin saturation (TSAT) 20% were randomized ferric derisomaltose (FDI) usual care. Relationships investigated baseline anaemia severity, TSAT, changes haemoglobin from 4 months, Minnesota Living Heart Failure...
Carbon dioxide reforming of methane to synthesis gas was studied by employing a Ni/La2O3 catalyst as well conventional nickel-based catalysts, i.e., Ni/γ-Al2O3, Ni/CaO/γ-Al2O3, and Ni/CaO. It is observed that, in contrast which exhibit continuous deactivation with time on stream, the rate reaction over increases during initial 2−5 h then tends be essentially invariable stream. X-ray photoelectron spectroscopy (XPS) studies show that surface carbon spent Ni/Al2O3 dominated −C−C− species...
Human recombinant histamine-releasing factor (HrHRF) is known to directly stimulate histamine release and IL-4 secretion from basophils of selected atopic donors in a reaction requiring the expression particular type IgE, referred as IgE+. In this study, HrHRF shown affect IgE-mediated IL-4, IL-13, not normally releasing protein (i.e, those expressing IgE-). Priming with several different concentrations for 15 min enhanced basophil after 4 h dose-dependent fashion following activation...
Background. Automated blood pressure (BP) devices are commonly used in doctor's offices. How BP measured on these relates to ambulatory monitoring is not clear. Objective. To assess how well office-based manual and automated predicts BP. Methods. Using data 654 patients, we assessed sphygmomanometer measurements taken with an device (BpTRU) predicted results monitoring. We positive negative predictive values overall accuracy. look at different cut-points for systolic (130, 135 140 mmHg)...
Despite increasing numbers in academic medicine, women remain underrepresented top leadership positions. The objectives of this study were to characterize positions held by department medicine (DOM) faculty at all ranks one Academic Health Center and compare male female faculty.This was a cross-sectional survey collect information on from 16 divisions the DOM Johns Hopkins University School Medicine early 2012, including type position, method used fill financial compensation. Chi-square...
Abstract Aim Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or free graft (UFG). This study aims to describe the contemporary management of female evaluate outcomes these three approaches. Methods a multi‐institutional, retrospective cohort evaluating operative treatment for stricture. Surgeries were grouped into categories: ENDO, ULT, UFG. Time from surgery recurrence by...
The measurement of blood pressure (BP) at home by patients with hypertension is increasingly used to assess and monitor BP. Evidence for its effectiveness in improving BP control mixed.To determine if monitoring improves a pragmatic cluster randomized contolled trial was carried out family practices southeastern Ontario, Canada. Family practice uncontrolled were recruited the trail. Patients divided into two groups: one least weekly measurements home, recording those showing physician during...
To characterize national trends in procedural management of renal trauma.Management trauma has evolved to favor a more conservative approach. For patients requiring intervention, there is paucity information the nature therapy administered.A retrospective cross-sectional analysis was performed using data contained within National Trauma Data Bank. The Bank voluntary repository managed by American College Surgeons, containing regarding admissions at 747 level I V centers throughout United...
Following the Dobbs decision overruling Roe vs. Wade, public interest in vasectomies increased. This ruling directly impacted urologic practice patterns, and warrants further investigation. To conduct a multi-institutional study quantifying change vasectomy volume between pre-Dobbs (PD) after-Dobbs (AD) eras. Multiple geographically distinct US academic medical centers participated study. Patients with an initial consult 1/1/2021 12/31/22 were included categorized as pre- (1/1/21 - 6/24/22)...
This Guideline covers the evaluation and treatment of men who present to a clinician with complaint chronic pelvic pain. is Part III three-part series focusing on scrotal content pain (CSCP). CSCP patients typically described in testes tenderness epididymis and/or spermatic cord. Patient education underlying etiology may promote discussion options, which often require multidisciplinary approach that includes management expectations through supportive counseling during treatment. For patient...
This Guideline covers the evaluation and treatment of men who present to a clinician with complaint chronic pelvic pain. is Part II three-part series focusing on prostatitis/ pain syndrome (CP/CPPS). A challenge for clinicians treating these patients necessity address symptoms etiologies outside usual urologic evaluation. Consequently, recommended utilizes multimodal/multidisciplinary approach that highlighted through discussion referral other specialists allied health professionals while...
This Guideline covers the evaluation and treatment of men who present to a clinician with complaint chronic pelvic pain. is Part I three-part series focusing on such patients. The presentation these widely variable. In addition pain, they may also have pain in many body areas outside pelvis. wide variety clinical presentations multidisciplinary diagnostic considerations makes management challenging. For discussion prostatitis/ syndrome (CP/CPPS) scrotal content (CSCP), refer Parts II this...
Abstract Glucocorticoids are widely used in the therapeutic intervention of allergic diseases, affecting function a variety proinflammatory cell types that participate these disorders. These drugs have been shown to inhibit release histamine by human basophils, but not mast cells, reaction requiring 8 24 h. To address whether generation IL-4 basophils is similarly affected, we investigated actions glucocorticoids on vitro this cytokine induced anti-IgE Ab or recombinant histamine-releasing...
Histamine releasing factor (HRF), also known as translationally controlled tumor protein (TCTP), is a highly conserved, ubiquitous that has both intracellular and extracellular functions. Here, we will highlight the history of molecule, its clinical implications with focus on functioning, potential role therapeutic target in asthma allergy. The cells cytokines produced when stimulated or primed by HRF/TCTP are detailed well downstream signaling pathway elicits. While it was originally...