A5059085082- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Muscle and Compartmental Disorders
- Machine Learning in Healthcare
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Artificial Intelligence in Healthcare
- Chronic Disease Management Strategies
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Healthcare cost, quality, practices
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Topic Modeling
- Parathyroid Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Artificial Intelligence in Healthcare and Education
- Cardiovascular Function and Risk Factors
- Autopsy Techniques and Outcomes
- Renal function and acid-base balance
- Renal and Vascular Pathologies
Icahn School of Medicine at Mount Sinai
2016-2025
Murphy Oil Corporation (United States)
2023-2025
New York Proton Center
2020-2025
Mount Sinai Hospital
2023-2024
NYU Langone Health
2023
New York University
2023
Creative Commons
2023
Long Island University
2023
Harvard University
2021-2023
McGill University
2023
<h3>Importance</h3> The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes critical illness from COVID-19. <h3>Objectives</h3> To assess factors associated with death to examine interhospital variation in treatment for patients <h3>Design, Setting, Participants</h3> This multicenter cohort study assessed 2215 adults laboratory-confirmed COVID-19 who were admitted intensive...
Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract inflammatory cytokine release syndrome severe COVID-19 illness.
Early reports indicate that AKI is common among patients with coronavirus disease 2019 (COVID-19) and associated worse outcomes. However, hospitalized COVID-19 in the United States not well described.
Significance Statement Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on treated with RRT (AKI-RRT) in patients COVID-19 are limited. In a multicenter cohort study 3099 critically ill adults admitted to intensive care units (ICUs) at 67 hospitals across the United States, one five developed AKI-RRT, 63% whom died during hospitalization. Among who survived hospital discharge, three remained dependent and six 60 days after ICU admission. The identified...
Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).
Abstract Aim Predicting progression in diabetic kidney disease (DKD) is critical to improving outcomes. We sought develop/validate a machine-learned, prognostic risk score (KidneyIntelX™) combining electronic health records (EHR) and biomarkers. Methods This an observational cohort study of patients with prevalent DKD/banked plasma from two EHR-linked biobanks. A random forest model was trained, performance (AUC, positive negative predictive values [PPV/NPV], net reclassification index...
Hereditary transthyretin (TTR) amyloid cardiomyopathy (hATTR-CM) due to the TTR V122I variant is an autosomal-dominant disorder that causes heart failure in elderly individuals of African ancestry. The clinical associations carrying variant, its effect other ancestry populations including Hispanic/Latino individuals, and rates achieving a diagnosis carriers are unknown.To assess association between identify hATTR-CM among with failure.Cross-sectional analysis noncarriers aged 50 years or...
OBJECTIVES: Therapies for patients with respiratory failure from coronavirus disease 2019 are urgently needed. Early implementation of prone positioning ventilation improves survival in acute distress syndrome, but studies examining the effect proning on lacking. Our objective was to estimate early initiation 2019–associated failure. DESIGN: Data were derived Study Treatment and Outcomes Critically Ill Patients 2019, a multicenter cohort study critically ill adults admitted 68 U.S....
Sepsis-associated AKI is a heterogeneous clinical entity. We aimed to agnostically identify sepsis-associated subphenotypes using deep learning on routinely collected data in electronic health records.We used the Medical Information Mart for Intensive Care III database, which consists of record from intensive care units tertiary hospital United States. included patients ≥18 years with sepsis who developed within 48 hours unit admission. then utilize all available vital signs, laboratory...
ABSTRACT Importance Preliminary reports indicate that acute kidney injury (AKI) is common in coronavirus disease (COVID)-19 patients and associated with worse outcomes. AKI hospitalized COVID-19 the United States not well-described. Objective To provide information about frequency, outcomes recovery dialysis patients. Design Observational, retrospective study. Setting Admitted to hospital between February 27 April 15, 2020. Participants P atients aged ≥18 years laboratory confirmed Exposures...
Background and objectives Hypernatremia is common in hospitalized, critically ill patients. Although there are no clear guidelines on sodium correction rate for hypernatremia, some studies suggest a reduction not to exceed 0.5 mmol/L per hour. However, the data supporting this recommendation optimal of hypernatremia hospitalized adults unclear. Design, setting, participants, & measurements We assessed association rates with neurologic outcomes mortality patients at admission those that...
Abstract Background Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal evaluation of this heterogenous syndrome. The role AKI based early trajectories is unclear. Methods This retrospective study identified Sepsis-3 who developed within 48-h intensive care unit admission using Medical Information Mart Intensive Care-IV database. We used...
Background: Acute kidney injury (AKI) is common in SARS-CoV-2 infection and COVID-19, often leading to long-term dysfunction. However, the transcriptomic features of AKI severity its effects are underexplored. Methods: We performed bulk RNA sequencing on peripheral blood mononuclear cells (PBMCs) from hospitalized patients complemented these findings with proteomic data same cohort. compared functional enrichment historical sepsis-AKI subsequently examined association between molecular...
Visual Abstract Export Background and objectives Patients are informed of the risk kidney biopsy–related complications using data from nonhospitalized patients, which may underestimate for hospitalized patients. We evaluated rate factors in patients with acute disease (AKD) to better estimate this population. Design, setting, participants, & measurements used Yale biopsy cohort evaluate rates including adjudicated procedure-related bleeding requiring blood transfusions or angiographic...
Intradialytic hypoxemia has been recognized for decades, but its associations with outcomes have not yet assessed in a large patient cohort.Our retrospective cohort study was conducted between January of 2012 and 2015. We recorded blood oxygen saturation every minute during hemodialysis patients arteriovenous access. A 6-month baseline period at least 10 treatments measurements preceded 12-month follow-up. Patients were stratified by the presence or absence prolonged intradialytic defined as...
Rationale: Variation in hospital mortality has been described for coronavirus disease (COVID-19), but the factors that explain these differences remain unclear. Objective: Our objective was to use a large, nationally representative data set of critically ill adults with COVID-19 determine which variability. Methods: In this multicenter cohort study, we examined hospitalized ICUs at 70 U.S. hospitals between March and June 2020. The primary outcome 28-day mortality. We patient-level...
Patients on maintenance hemodialysis (HD) are highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1). Work by us and others shows that patients HD mount an antibody (Ab) response following SARS-CoV-2 infection, but the Ab titers decline over time (2,3). The mRNA-1273 vaccine (Moderna) is directed against spike protein of elicits receptor binding domain (RBD) protein, which has neutralizing properties (4). We collected data IgG Moderna in outpatient...
Acute kidney injury (AKI) is a known complication of COVID-19 and associated with an increased risk in-hospital mortality. Unbiased proteomics using biological specimens can lead to improved stratification discover pathophysiological mechanisms.
Significance Statement Studies have shown significant racial and ethnic disparities in the end-of-life care received by dialysis patients with ESKD United States, but little is known about disparity palliative services such inpatient setting. This retrospective cohort study of 5,230,865 hospitalizations on found that, despite a increase use from 2006 through 2014, remained underused. Black Hispanic were less likely than white to receive hospital, that persisted all hospital subtypes,...