Adam Green
A5021375048- Glioma Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neuroblastoma Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- Hemodynamic Monitoring and Therapy
- Ultrasound and Hyperthermia Applications
- Childhood Cancer Survivors' Quality of Life
- Diabetic Foot Ulcer Assessment and Management
- EEG and Brain-Computer Interfaces
- Brain Metastases and Treatment
- Pneumothorax, Barotrauma, Emphysema
- Chromatin Remodeling and Cancer
- Shoulder Injury and Treatment
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Disaster Response and Management
- Epigenetics and DNA Methylation
- Renal and related cancers
- Cardiac Structural Anomalies and Repair
- Nuclear Structure and Function
Cooper Medical School of Rowan University
2021-2025
Cooper University Health Care
2020-2025
Cooper University Hospital
2021-2024
Georgetown University
2021-2024
University of Colorado Anschutz Medical Campus
2017-2024
University of Colorado Denver
2015-2023
Morgan Adams Foundation
2017-2023
Children's Hospital Colorado
2015-2023
The Ohio State University
2021-2023
Association Clinique et Thérapeutique Infantile du Val de Marne
2023
<h3>Importance</h3> The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes critical illness from COVID-19. <h3>Objectives</h3> To assess factors associated with death to examine interhospital variation in treatment for patients <h3>Design, Setting, Participants</h3> This multicenter cohort study assessed 2215 adults laboratory-confirmed COVID-19 who were admitted intensive...
Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract inflammatory cytokine release syndrome severe COVID-19 illness.
Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).
Abstract Background Central nervous system (CNS) atypical teratoid rhabdoid tumors (AT/RT) are rare of childhood with a dismal prognosis. Historically, surgery and standard dose chemotherapy have resulted in median survival 8.5 months from diagnosis. Methods Thirteen children newly diagnosed CNS AT/RT were treated either the “Head Start I” (HS I) or II” II) regimens. Therapy included resection followed by five cycles cisplatin, vincristine, cyclophosphamide, etoposide. High methotrexate was...
OBJECTIVES: Therapies for patients with respiratory failure from coronavirus disease 2019 are urgently needed. Early implementation of prone positioning ventilation improves survival in acute distress syndrome, but studies examining the effect proning on lacking. Our objective was to estimate early initiation 2019–associated failure. DESIGN: Data were derived Study Treatment and Outcomes Critically Ill Patients 2019, a multicenter cohort study critically ill adults admitted 68 U.S....
Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization embryos for genetic liability adult diseases, despite a lack of comprehensive modeling expected outcomes. Here we predict, based on the threshold model, reduction complex disease following polygenic embryo screening single disease. A strong determinant potential utility such is selection strategy , factor that has not previously studied. When only with very high PRS are excluded, achieved minimal. In...
Rationale: Variation in hospital mortality has been described for coronavirus disease (COVID-19), but the factors that explain these differences remain unclear. Objective: Our objective was to use a large, nationally representative data set of critically ill adults with COVID-19 determine which variability. Methods: In this multicenter cohort study, we examined hospitalized ICUs at 70 U.S. hospitals between March and June 2020. The primary outcome 28-day mortality. We patient-level...
To examine trends in utilization and outcomes among patients with the acute respiratory distress syndrome (ARDS) requiring prolonged venovenous extracorporeal membrane oxygenation (VV ECMO) support.
The impact of the duration noninvasive respiratory support (RS) including high-flow nasal cannula and ventilation before initiation extracorporeal membrane oxygenation (ECMO) is unknown. We reviewed data patients with coronavirus disease 2019 (COVID-19) treated V-V ECMO at two high-volume tertiary care centers. Survival analysis was used to compare effect RS on liberation from ECMO. A total 78 required median invasive mechanical (IMV) 2 days (interquartile range [IQR]: 0, 6) 2.5 (IQR: 1, 5),...
Background Diffuse midline glioma (DMG) is an incurable brain cancer without a single FDA-approved drug that prolongs survival. CDK4/6 inhibitors have been evaluated in children with DMG limited efficacy. Since MAPK pathway activation upstream of cell proliferation, we hypothesized MEK may increase the anti-tumor effects inhibitors. Here, efficacy inhibitor ribociclib and trametinib human murine models to investigate combinational effects. Methods We conducted vitro vivo assays using lines...
Using three types of models, researchers studied mixing and water quality in an aboveground cylindrical reservoir. Long detention times improper tanks reservoirs may negatively affect quality. Mathematical physical models dynamics be used to determine how alternative designs or operational policies the within leaving facility. Three models—a systems model that uses a simplified representation reservoir emphasizing input output from facility, computational fluid based on mathematical...
Abstract The repeat dose toxicity of various liposomal formulations containing amphotericin B has been determined in mice. In general, small liposomes (e.g. 100–150 nm) were found to be more toxic than their larger counterparts about 2000 nm). However, the could diminished substantially by inclusion sterol (i.e. ergosterol) into membranes. Tissue accumulation studies after dosing may a useful adjunct formulation development.
Background: Orthopedic reductions are commonly performed procedures requiring sedation in the pediatric emergency department (PED). Ketamine is a widely used agent for procedural sedation, but its use may present difficulties select populations, such as those with psychiatric diagnoses. In case, alternative agents that safe and effective needed. Etomidate induction rapid-sequence intubation PED. Several retrospective few prospective studies support etomidate's safety efficacy sedation....