A5007689491- Advanced Glycation End Products research
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Natural Antidiabetic Agents Studies
- Renal function and acid-base balance
- Nutritional Studies and Diet
- Central Venous Catheters and Hemodialysis
- Fatty Acid Research and Health
- Muscle and Compartmental Disorders
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Vascular Procedures and Complications
- Magnesium in Health and Disease
- Potassium and Related Disorders
- Folate and B Vitamins Research
- Ion Transport and Channel Regulation
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Alcohol Consumption and Health Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Iron Metabolism and Disorders
- Biochemical effects in animals
- Renal and Vascular Pathologies
- Cardiovascular Health and Disease Prevention
- Vascular anomalies and interventions
Icahn School of Medicine at Mount Sinai
2016-2025
Mount Sinai Health System
2021-2024
Mount Sinai Hospital
1999-2021
Mount Sinai Hospital
2015-2020
Mount Sinai Medical Center
1995-2017
Center for Food Safety and Applied Nutrition
2014
United States Food and Drug Administration
2014
Diabetes Australia
2012
Ayuntamiento de Bilbao
2012
Emory University
2008
Background. Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, renal also AGEs are readily derived from heat-treated foods. We propose that the excess consumption certain via diet enhances OS responses in healthy adults, especially elderly persons. Methods. examined 172 young (<45 years old) older (>60 individuals determine whether...
The purpose of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) levels and prevalence peripheral arterial disease (PAD) in general United States population.We analyzed data from 4839 participants National Health Nutrition Examination Survey 2001 2004 evaluate relationship 25(OH)D PAD (defined as an ankle-brachial index < 0.9). Across quartiles 25(OH)D, lowest highest, 8.1%, 5.4%, 4.9%, 3.7% (P trend 0.001). After multivariable adjustment for demographics,...
OBJECTIVE Increased oxidative stress (OS) and impaired anti-OS defenses are important in the development persistence of insulin resistance (IR). Several anti-inflammatory cell-protective mechanisms, including advanced glycation end product (AGE) receptor-1 (AGER1) sirtuin (silent mating-type information regulation 2 homolog) 1 (SIRT1) suppressed diabetes. Because basal OS type diabetic patients is influenced by consumption AGEs, we examined whether AGE also affects IR AGER1 SIRT1 involved....
ABSTRACT. Advanced glycation endproduct (AGE) levels are elevated in renal failure patients and may contribute to the excessive cardiovascular disease this population. Diet-derived AGE major contributors total body pool. It was postulated that a reduction dietary intake might impact on high circulating patients. Twenty-six nondiabetic maintenance peritoneal dialysis were randomized either or low diet for 4 wk. Three-day records, fasting blood, 24-h urine, fluid collections obtained at...
Diabetes is characterized by marked postprandial endothelial dysfunction induced hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation could be blocked benfotiamine, but in vivo effects of benfotiamine on synthesis have not been investigated humans until now.Thirteen people with type 2 diabetes were given a heat-processed test meal high AGE content (HAGE; 15.100 kU, 580 kcal, 54 g...
Editor’s note: This is one in a series of articles from the various professional section councils American Diabetes Association. installment Council on Complications. The incidence diabetes, particularly type 2 increasing at an alarming rate. Worldwide, about 124 million people had diabetes by1997; by 2010, this number estimated to reach 221 million. Because large severe pathologies complicating clinical course can easily speculate huge economic and psychosocial impact across age groups...
Context: Increased oxidant stress and inflammation (OS/infl) are linked to both aging-related diseases advanced glycation end products (AGEs). Whereas AGE receptor-1 (AGER1) reduces OS/infl in animals, this has not been assessed normal humans. Objective: The objectives of the study were determine whether AGER1 correlates with AGEs a reduction dietary (dAGEs) lowers healthy adults chronic kidney disease (CKD-3) patients. Design: This was cross-sectional 2-yr follow-up studies CKD-3 patients,...
Dietary advanced glycosylation end products (AGEs) have been linked to insulin resistance in db/db(++) mice. To test whether dietary AGEs play a role the progression of normal mice fed high-fat diets, C57/BL6 were randomly assigned diets (35% g fat), either high (HAGE-HF group; 995.4 units/mg AGE) or low (by 2.4-fold LAGE-HF 329.6 AGE content for 6 months. Age-matched and regular diet (5% fat, 117.4 served as controls. After months, 75% HAGE-HF diabetic exhibited higher body weight (P...
Patients with end-stage renal disease (ESRD) undergoing hemodialysis are known to suffer cognitive deficits and stroke of unknown etiology. It has been suspected that the treatment itself may contribute syndrome by mechanisms, which we investigated in this study. End-stage patients on (n=19) or peritoneal dialysis (PD, n=5) were compared 14 healthy controls. Subjects participated magnetic resonance imaging (MRI) measurements cerebral atrophy, blood flow (CBF) arterial spin labeled-MRI...
Advanced glycation end products, known pro-inflammatory and pro-oxidative compounds that accumulate in patients with chronic kidney disease, may play a major role their high prevalence of endothelial dysfunction subsequent cardiovascular disease. This study examined the association advanced product accumulation cellular receptor for expression as well mechanisms this disease.A cross-sectional was conducted ambulatory without diabetes different stages disease (n = 51), compared gender-...
The current study was designed to test the acute effects of dietary advanced glycation end products (AGEs) on endothelial function diabetic and nondiabetic subjects.Flow-mediated dilation (FMD) brachial artery serum levels AGEs, plasminogen activator inhibitor 1 (PAI-1), vascular cell adhesion molecule (VCAM-1), glucose were assessed before after a single oral AGE challenge (approximately 1.8 x 10(6) units) in 44 10 subjects.The patients had higher baseline AGEs (P = 0.020), PAI-1 (NS),...