A5101587097- Parathyroid Disorders and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Magnesium in Health and Disease
- Pharmacological Effects and Toxicity Studies
- Bone health and osteoporosis research
- Bone health and treatments
- Renal function and acid-base balance
- Genetic Syndromes and Imprinting
- Bone and Joint Diseases
- Nutrition and Health in Aging
- Thyroid and Parathyroid Surgery
- Potassium and Related Disorders
- Diet and metabolism studies
- Therapeutic Uses of Natural Elements
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Historical Studies of Medieval Iberia
- Dermatological and Skeletal Disorders
- Iron Metabolism and Disorders
- Medieval Architecture and Archaeology
Instituto de Investigación Sanitaria del Principado de Asturias
2013-2025
Instituto de Salud Carlos III
2015-2025
Universidad de Oviedo
2012-2025
Central University Hospital of Asturias
1993-2024
Red de Investigación en Sida
2010-2023
Universidad de Salamanca
2015
Imperial College London
1997-2014
Universidade Nova de Lisboa
2013
Centre de Recherche en Nutrition Humaine d'Auvergne
2011
University of Leeds
2004
This report presents a methodology for measuring the performance of supercomputers. It includes 13 Fortran programs that total over 50,000 lines source code. They represent applications in several areas engi neering and scientific computing, many cases codes are currently being used by computational re search development groups. We also present PERFECT standard, set guidelines allow portability to types machines. Furthermore, we some measures method ology recording sharing results among...
Abnormalities in serum phosphorus, calcium and parathyroid hormone (PTH) have been associated with poor survival haemodialysis patients. This COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) analysis assesses the association of high low PTH relative risk mortality. Furthermore, impact changes these parameters on mortality throughout 3-year follow-up has investigated. is 3-year, multicentre, open-cohort, prospective study carried out 6797 adult...
Mineral metabolism parameters may play a role in the survival of patients with chronic kidney disease (CKD).In CORES Study, we analysed association between calcium, phosphorus and PTH mortality (all-cause cardiovascular) 16 173 haemodialysis (HD) over 18 years from six Latin American countries, who underwent up to 54 months. Unadjusted, case-mix-adjusted time-dependent multivariable-adjusted hazard ratio (HR) death were calculated for categories serum albumin-corrected calcium (Ca(Alb)),...
Vitamin D status has been implicated in COVID-19 disease. The objective of the COVID-VIT-D trial was to investigate if an oral bolus cholecalciferol (100,000 IU) administered at hospital admission influences outcomes moderate-severe In same cohort, association between baseline serum calcidiol levels with also analysed.The is a multicentre, international, randomised, open label, clinical conducted throughout 1 year. Patients older than 18 years disease requiring hospitalisation were included....
The mechanisms by which estrogens modulate PTH are controversial, including whether or not estrogen receptors (ERs) present in the parathyroid glands. To explore these mechanisms, we combined a rat model of CKD with ovariectomy and exogenous administration estrogens. We found that treatment significantly decreased mRNA serum levels. did observe ERalpha ERbeta protein parathyroids, suggesting an indirect action on regulation. Estrogen 1,25(OH)(2) vitamin D(3) phosphorus In addition, increased...
Chronic kidney disease–mineral and bone disorders (CKD–MBD) are important complications of CKD5D patients that associated with mortality. COSMOS is a multicentre, open cohort, prospective, observational 3-year study carried out in haemodialysis from 20 European countries during 2005–07. The present article describes the main characteristics dialysis population, current practice for prevention, diagnosis treatment secondary hyperparathyroidism differences across different regions. population...
Vascular calcification is a frequent cause of morbidity and mortality in patients with CKD the general population. The common association between vascular osteoporosis suggests link bone disorders. Because microRNAs (miRs) are involved transdifferentiation smooth muscle cells into osteoblast-like cells, we investigated whether miRs implicated osteoblast differentiation formation calcification. Different levels uremia, hyperphosphatemia, aortic were induced by feeding nephrectomized rats...
Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and contributes to development cardiac renal dysfunction. The aim this experimental study, performed a rat model, which resembles type 1 diabetes mellitus, was investigate soluble Klotho (sKlotho), advanced glycation end products (AGEs)/receptor for AGEs (RAGE), fibrotic Wnt/β-catenin pathway, pro-fibrotic pathways kidney heart. Diabetes induced by streptozotocin. Glycaemia maintained insulin...
Shortly after the discovery of Klotho, interest grew in its potential role chronic kidney disease (CKD). There are three isoforms Klotho protein: αKlotho, βKlotho and γKlotho. This review will focus on αKlotho due to relevance as a biomarker CKD. is synthesized mainly kidneys, but it can be released into bloodstream urine soluble (sKlotho), which undertakes systemic actions, independently or combination with FGF23. It usually accepted that sKlotho levels reduced early CKD lower might...
Using myoelectric recording techniques, we examined the effects of castor oil; ricinoleic acid (cis isomer), active ingredient and ricinelaidic (trans isomer) in small intestine New Zealand white rabbits. Ricinoleic acid, 2 microgram/kg per min (6mM), was perfused into a distal 12-cm ileal loop. An abnormal pattern developed that similar to alteration electrical activity has previously been reported for cholera enterotoxin. Castor oil, 0.85 ml/kg, had effect. Ricinelaidic min, induced no...
Summary Background and Objectives A high body mass index (BMI) is associated with lower mortality in patients undergoing hemodialysis. Short-term weight gains losses are also related to higher risk, respectively. The implications of gain or loss may, however, differ between obese individuals their nonobese counterparts. Design, Setting, Participants, & Measurements Current Management Secondary Hyperparathyroidism: Multicenter Observational Study (COSMOS) an observational study including...
In chronic kidney disease, the activation of renin-angiotensin-aldosterone system (RAAS) and renal inflammation stimulates fibrosis progression to end-stage disease. The low levels vitamin D receptor (VDR) its activators (VDRAs) contribute worsen secondary hyperparathyroidism fibrosis.The 7/8 nephrectomy model experimental failure (CRF) was used examine anti-fibrotic effects treatment with two VDRAs, paricalcitol calcitriol, at equivalent doses (3/1 dose ratio) during 4 weeks.CRF increased...
ABSTRACT Background Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between current biochemical parameters of chronic kidney disease–mineral bone disorders (CKD-MBD) in COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) project. Methods is 3-year, multicentre, open cohort, prospective, observational carried out 6797 haemodialysis patients (227 centres from 20 European countries). The...
Bone represents a metabolically active tissue subject to continuous remodeling orchestrated by the dynamic interplay between osteoblasts and osteoclasts. These cellular processes are modulated complex of biochemical mechanical factors, which instrumental in assessing bone remodeling. This comprehensive evaluation aids detecting disorders arising from imbalances formation reabsorption. Osteoporosis, characterized reduction mass strength leading heightened fragility susceptibility fractures,...
Previous studies have shown that antibodies in the sera of halothane hepatitis patients recognize trifluoroacetylated liver microsomal proteins (neoantigens) 100 kDa, 76 59 57 and 54 kDa. In present investigation, factors might affect level expression neoantigens were investigated. A study time course neoantigen halothane-treated rats revealed kDa longer-lived than could be detected up to a week after administration halothane. Pretreatment with isoniazid, which is known induce cytochrome...