A5015960013- Obstructive Sleep Apnea Research
- Water Treatment and Disinfection
- Nutritional Studies and Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Air Quality and Health Impacts
- Cancer Risks and Factors
- Noise Effects and Management
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Electromagnetic Fields and Biological Effects
- Respiratory Support and Mechanisms
- Radiation Dose and Imaging
- Chemical Analysis and Environmental Impact
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Consumer Attitudes and Food Labeling
- Environmental Chemistry and Analysis
- Global Cancer Incidence and Screening
- Intensive Care Unit Cognitive Disorders
- Fecal contamination and water quality
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Obesity, Physical Activity, Diet
Biomedical Research Institute of Lleida
2020-2025
Hospital Universitari Arnau de Vilanova
2021-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2021-2024
Instituto de Salud Carlos III
2017-2024
Universitat de Lleida
2021-2023
Universitat Pompeu Fabra
2014-2022
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2013-2022
Barcelona Institute for Global Health
2016-2022
Hospital del Mar Research Institute
2013-2021
Hospital Del Mar
2011-2021
Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM levels water the European Union as a marker of DBP estimated attributable burden cancer. Methods: collected recent annual mean municipal 28 countries (EU28) from routine monitoring records. linear exposure–response function for average residential by pooling data studies...
It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk.
Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.We evaluated the of urinary concentrations 24 chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide and cotinine, between weeks from different pregnancy trimesters pregnant women, days seasons children.154 women 152 children six European countries were enrolled 2014-2015. Pregnant provided three urine...
Ingested nitrate leads to the endogenous synthesis of N-nitroso compounds (NOCs), animal carcinogens with limited human evidence. We aimed evaluate risk colorectal cancer (CRC) associated exposure in drinking water and diet. A case-control study Spain Italy during 2008-2013 was conducted. Hospital-based incident cases population-based (Spain) or hospital-based (Italy) controls were interviewed on residential history, consumption since age 18, dietary information. Long-term waterborne...
Background Hypoxic burden (HB) has emerged as a strong predictor of cardiovascular risk in obstructive sleep apnoea (OSA). We aimed to assess the potential HB predict benefit treating OSA with continuous positive airway pressure (CPAP). Methods This was post hoc analysis ISAACC trial ( ClinicalTrials.gov : NCT01335087 ) including non-sleepy patients acute coronary syndrome (ACS) diagnosed (apnoea–hypopnoea index ≥15 events·h −1 by respiratory polygraphy. Patients were randomised CPAP or...
Rationale: Randomized controlled trials of continuous positive airway pressure (CPAP) therapy for cardiovascular disease (CVD) prevention among patients with obstructive sleep apnea (OSA) have been largely neutral. However, given OSA is a heterogeneous disease, there may be unidentified subgroups demonstrating differential treatment effects. Objectives: Apply novel data-drive approach to identify non-sleepy effects CPAP on CVD outcomes within the ISAACC study. Methods: Participants were...
Prostate, breast and colorectal cancer are the most common tumours in Spain. The aim of present study was to evaluate association between adherence nutrition-based guidelines for prevention prostate, cancer, MCC-Spain case-control study. A total 1,718 colorectal, 1,343 864 prostate cases 3,431 population-based controls recruited 2007 2012, were included World Cancer Research Fund/American Institute (WCRC/AICR) score based on six recommendations (on body fatness, physical activity, foods...
Background:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent.Objectives:We assessed long-term trihalomethanes (THMs), most prevalent group of chlorination by-products, evaluate with cancer.Methods:A multicenter case–control study was conducted Spain Italy 2008–2013. Hospital-based incident cases population-based (Spain) hospital-based (Italy) controls were interviewed ascertain residential histories, type consumed...
Inflammation and antioxidant capacity have been associated with colorectal breast cancer. We computed the dietary inflammatory index (DII®), total non-enzymatic (NEAC) them cancer risk in population-based multi case-control study Spain (MCC-Spain). included 1852 1567 cases, 3447 1486 population controls, respectively. DII score NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models used to estimate odds ratios...
Although outdoor air pollution and particulate matter in have been consistently linked with increased lung cancer risk, the evidence for associations at other sites is limited. Bladder shares several risk factors some positive of ambient bladder observed. This study examined large-scale Spanish Cancer Study. Estimates fine (PM2.5 ) nitrogen dioxide (NO2 concentrations were assigned to geocoded participant residence 938 incident cases 973 hospital controls based on European multicity land-use...
We examined the association between exposure during pregnancy to trihalomethanes, most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure Disinfection By-Products Drinking Water). took into account through different uses, measures toxicity, genetic susceptibility.We enrolled 14,005 mothers (2002-2010) their children from France, Greece, Lithuania, Spain, UK. Information on lifestyle- water-related activities was...
Type 2 diabetes mellitus has been associated with an excess risk of colorectal cancer, although the time-risk relationship is unclear, and there limited information on role antidiabetic medications. We examined association between type diabetes, medications, considering also duration exposures. analyzed data derived from two companion case-control studies conducted in Italy Spain 2007 2013 1,147 histologically confirmed cancer cases 1,594 corresponding controls. Odds ratios (ORs) 95%...
Trihalomethanes (THM) are undesired disinfection byproducts (DBPs) formed during water treatment. Mice exposed to DBPs showed global DNA hypomethylation and c-myc c-jun gene-specific hypomethylation, while evidence of epigenetic effects in humans is scarce. We explored the association between lifetime THM exposure methylation through an epigenome-wide study. selected 138 population-based controls from a case-control study colorectal cancer conducted Barcelona, Spain, average levels ≤85 μg/L...
There are many different methods used to measure the degree of adherence a Mediterranean diet (MD), limiting comparison and interpretation their results. The concordance between methodologies has been questioned evaluation recommended. aim this study was evaluate agreement among five indexes that dietary pattern. population included healthy adults selected in Multi-Case Control Spain (MCC-Spain) recruited 12 provinces. A total 3640 controls were matched cases by age sex. To reach aim,...
Swimming in pools is a healthy activity that entails exposure to disinfection by-products (DBPs), some of which are irritant and genotoxic. We evaluated DBPs during swimming chlorinated pool the association with short-term changes genotoxicity lung epithelium permeability biomarkers. Non-smoker adults (N = 116) 40 min an indoor were included. measured range biomarkers before at different times after swimming: trihalomethanes (THMs) exhaled breath (5 min), trichloroacetic acid (TCAA) urine...
The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID protected against cancer, while most cohort did not find this effect. have dealt with NSAIDs as a whole group or specific drugs, such aspirin, ibuprofen, others, but subgroups according to Anatomical Therapeutic Chemical Classification System; moreover, scarce attention paid...
Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water associated with colorectal cancer risk but mechanisms not well understood.We explored the association between exposure to THMs inflammation markers, link risk.A subset of 198 cases 205 controls from multicase-control study MCC-Spain were included. Average concentration (chloroform, bromodichloromethane, dibromochloromethane, bromoform) tap at residence was estimated age 18 until 2 years before interview ("long...