A5059674840- Sleep and Wakefulness Research
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Obstructive Sleep Apnea Research
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Mind wandering and attention
- Non-Invasive Vital Sign Monitoring
- Sleep and Work-Related Fatigue
- Spinal Fractures and Fixation Techniques
- Heart Rate Variability and Autonomic Control
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
- Restless Legs Syndrome Research
- Spinal Dysraphism and Malformations
- Neurological and metabolic disorders
- Neonatal and fetal brain pathology
- Congenital heart defects research
- Pharmacological Effects and Toxicity Studies
Netherlands Institute for Neuroscience
2023-2025
University Hospital of Lausanne
2010-2024
The Sense Innovation and Research Center
2022-2024
University of Lausanne
2014-2023
Hôpital Orthopédique de la Suisse Romande
2018-2023
University of Stirling
2020
University of Wisconsin–Madison
2013-2018
University Hospital of Zurich
2010-2011
Service de la Santé Publique
2009
Johns Hopkins Hospital
2007
It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk.
To assess how the characteristics of slow waves and spindles change in falling-asleep process. Participants undergoing overnight high-density electroencephalographic recordings were awakened at 15- to 30-min intervals. One hundred forty-one periods analyzed scalp source level. Sleep laboratory. Six healthy participants. Serial awakenings. The number amplitude followed two dissociated, intersecting courses during transition sleep: wave increased slowly beginning rapidly end period, whereas...
Dreaming - a particular form of consciousness that occurs during sleep undergoes major changes in the course night. We aimed to outline state-dependent features using paradigm with multiple serial awakenings/questionings allowed for within as well between subject comparisons. Seven healthy participants who spent 44 experimental study nights laboratory were awakened by computerized sound at 15-30 minute intervals, regardless stage, and questioned presence or absence consciousness. Recall...
Previous work showed that two types of slow waves are temporally dissociated during the transition to sleep: widespread, large and steep predominate early in falling asleep period (type I), while smaller, more circumscribed become prevalent later II). Here, we studied possible occurrence these stable non-REM (NREM) sleep explored potential differences their regulation. A heuristic approach based on wave synchronization efficiency was developed applied high-density electroencephalographic...
Recent work has demonstrated that behavioral manipulations targeting specific cortical areas during prolonged wakefulness lead to a region-specific homeostatic increase in theta activity (5–9 Hz), suggesting waves could represent transient neuronal OFF periods (local sleep). In awake rats, the occurrence of an period brain area relevant for behavior results performance errors. Here we investigated potential relationship between local sleep events and negative outcomes humans. Volunteers...
Although the EEG slow wave of sleep is typically considered to be a hallmark nonrapid eye movement (NREM) sleep, recent work in mice has shown that waves can also occur REM sleep. Here, we investigated presence and cortical distribution negative delta (1–4 Hz) human by analyzing high-density recordings obtained 28 healthy subjects. We identified two clusters with distinctive properties: (1) frontal-central cluster characterized ∼2.5–3.0 Hz, relatively large, notched (so-called “sawtooth...
Dreaming can occur in both rapid eye movement (REM) and non-REM (NREM) sleep. We recently showed that REM NREM sleep, dreaming is associated with local decreases slow wave activity (SWA) posterior brain regions. To expand these findings, here we asked how specific features of waves spindles, the hallmarks relate to dream experiences. Fourteen healthy human subjects (10 females) underwent nocturnal high-density EEG recordings combined a serial awakening paradigm. Reports dreaming, compared...
The weighted Phase Lag Index (wPLI) and the Symbolic Mutual Information (wSMI) represent two robust widely used methods for MEG/EEG functional connectivity estimation. Interestingly, both have been shown to detect relative alterations of brain in conditions associated with changes level consciousness, such as following severe injury or under anaesthesia. Despite these promising findings, it was unclear whether wPLI wSMI may account distinct similar types interactions. Using simulated...
Sleepwalking and related parasomnias result from incomplete awakenings out of non-rapid eye movement sleep. Behavioral episodes can occur without consciousness or recollection, in relation to dream-like experiences. To understand what accounts for these differences recall, here we recorded parasomnia with high-density electroencephalography (EEG) interviewed participants immediately afterward about their Compared reports no experience (19%), conscious (56%) were preceded by high-amplitude...
Abstract Feeling awake although sleep recordings indicate clear-cut sometimes occurs in good sleepers and to an extreme degree patients with so-called paradoxical insomnia. It is unknown what underlies misperception, as standard polysomnographic (PSG) parameters are often normal these cases. Here we asked whether regional changes brain activity could account for the mismatch between objective subjective total times (TST). To set cutoffs define norm, first evaluated perception a...
Summary Although excessive daytime sleepiness is commonly evaluated in clinical and research settings using the Epworth Sleepiness Scale, few studies have assessed factors associated with its incidence general population. We prospectively investigated predictors of incident persistent 2,751 subjects (46.1% men, mean age 56.0 ± 9.8 years) from CoLaus‐PsyCoLaus population‐based cohort (Lausanne, Switzerland) over 5 years. Participants completed Scale Pittsburgh Sleep Quality Index, underwent a...
<b>BACKGROUND AND PURPOSE:</b> A certain number of anatomic variants involving the distal vertebral artery (VA) are explained by variations in size and connection lateral spinal (LSA). This study examined possible role another branch VA, posterior (PSA), development similar vascular variations. <b>MATERIALS METHODS:</b> Four types including C1 C2 origins inferior cerebellar (PICA), duplication aberrant course illustrated 9 angiographic observations. <b>RESULTS:</b> For each type VA variant...
Abstract When subjects become unconscious, there is a characteristic change in the way cerebral cortex responds to perturbations, as can be assessed using transcranial magnetic stimulation and electroencephalography (TMS–EEG). For instance, compared wakefulness, during non-rapid eye movement (NREM) sleep TMS elicits larger positive–negative wave, fewer phase-locked oscillations an overall simpler response. However, many physiological variables also when go from wake sleep, anesthesia, or...
The slow waves of non-rapid eye movement (NREM) sleep reflect experience-dependent plasticity and play a direct role in the restorative functions sleep. Importantly, behave as traveling waves, their propagation is assumed to occur through cortico-cortical white matter connections. In this light, corpus callosum (CC) may represent main responsible for cross-hemispheric slow-wave propagation. To verify hypothesis, we performed overnight high-density (hd)-EEG recordings five patients who...
EEG slow waves, the hallmarks of NREM sleep are thought to be crucial for regulation several important processes, including learning, sensory disconnection and removal brain metabolic wastes. Animal research indicates that waves may involve complex interactions within between cortical subcortical structures. Conventional in humans, however, has a low spatial resolution is unable accurately describe changes activity deep To overcome these limitations, here we took advantage simultaneous...
Summary Sleepwalking and related parasomnias are thought to result from incomplete awakenings out of non‐rapid eye movement (non‐REM) sleep. Non‐REM parasomnia behaviours have been described as unconscious automatic, or vivid, dream‐like conscious experiences. Similarly, some observations suggested that patients unresponsive during episodes, while others they can interact with their surroundings. To better grasp characterise the full spectrum consciousness environmental (dis)connection...