A5051904000- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Data-Driven Disease Surveillance
- Fluoride Effects and Removal
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Atmospheric Ozone and Climate
- Gestational Diabetes Research and Management
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obesity, Physical Activity, Diet
- Climate Change and Health Impacts
- Healthcare Systems and Technology
Barcelona Institute for Global Health
2016-2023
Universitat Pompeu Fabra
2015-2023
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015-2023
IQ Solutions
2021
IQVIA (United States)
2021
Universitat Autònoma de Barcelona
2019
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2019
Center for Research in Environmental Epidemiology
2015-2017
Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.We evaluated the of urinary concentrations 24 chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide and cotinine, between weeks from different pregnancy trimesters pregnant women, days seasons children.154 women 152 children six European countries were enrolled 2014-2015. Pregnant provided three urine...
Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy a period of enhanced tissue plasticity fetus and mother be critical window PFAS exposure susceptibility.We evaluated associations between exposures outcomes in pregnant women.We analyzed 1,240 women from Spanish INMA [Environment Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with...
Background: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce inconsistent. Objectives: We estimated associations between prenatal PFAS exposures outcomes relevant to risk, including a composite CM-risk score. Methods: measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) in maternal plasma (first trimester)....
Electronic health records are becoming an increasingly valuable resource for epidemiology but their data quality needs to be quantified. We aimed validate twenty-five types of incident cancer cases in the Information System Research Primary Care (SIDIAP) Catalonia with population-based registries Girona and Tarragona as gold-standard.We calculated sensitivity, positive predictive values (PPV), time-difference between date diagnosis entered into SIDIAP registries. added hospital discharge...
Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied PFASs biometry.In 1230 mother-child pairs of three cohorts from Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) in first-trimester maternal plasma (collection: 2003-2008)....
Prenatal exposures to perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic (PFOA) have been associated with child health outcomes, but many of these associations remain poorly characterized. The aim this work was provide new indicators foetal exposure for the Spanish INMA birth cohort. First, a pregnancy lactation physiologically based pharmacokinetic (PBPK) model calibrated in population framework quantitative estimates PFOA PFOS placental transfers humans. estimated distributions...
Results of studies on perfluoroalkyl substances (PFASs) and thyroid hormones (THs) are heterogeneous, the mechanisms underlying action PFASs to target THs have not been fully characterized. We examined relation between first-trimester maternal PFAS TH levels role played by polymorphisms in iodothyronine deiodinase 1 (
Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) may affect child growth; thus estimating PFAS fetal body burden is relevant. considered best estimated in cord samples; however previous cohort studies have used either maternal plasma or serum indistinctively during pregnancy as proxy. We evaluated the correlations and transfer ratio between concentration pregnancy, at birth a Spanish cohort. Methods: measured perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic...
Introduction: Perfluoroalkyl substance (PFAS) exposure has been associated with higher cardio-metabolic (CM) risk in adults but less evidence exists for children. We studied the effect of prenatal PFAS on CM at 4 and 7 years a Spanish birth cohort. Methods: measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) maternal plasma (2003-2008). At (n=1,200) (n=815) age, we assessed age-and sex-specific z-scores body mass...
Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) may play a role in childhood obesity; however evidence from prospective studies is limited. We evaluated the effect of prenatal PFAS on postnatal rapid growth at 6 months life and overweight 4 years age Spanish birth cohort. Methods: assessed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) 1,234 maternal plasma samples collected 12 weeks pregnancy....
Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) might affect child health; but maternal determinants of PFAS are unclear. We evaluated whether socio-demographic and dietary factors predict concentrations during pregnancy in a birth cohort. Methods: analyzed the perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) 1,239 plasma samples at 10-13 weeks collected 2003-2008. Women also completed questionnaire...
Children exposure to per- and polyfluoroalkyl acids substances (PFAS) is a major concern in health risk assessment as early-life exposures are suspected induce adverse effects such cardiometabolic, neurodevelopmental, or impact on immune response. Our work aims estimate children PFOA PFOS using Physiologically-Based Pharmacokinetic (PBPK) modelling approach. A lifetime model for PFAS was updated simulate the internal during utero life childhood, include individual characteristics scenarios....
Prenatal exposure to perfluoroalkyl substances (PFAS) may be associated with impaired immune and respiratory health during childhood but the evidence is scarce inconsistent. We studied association between prenatal PFAS up age 7 years in Spanish INMA birth cohort (n=1188). assessed perfluorohexane sulfonate (PFHxS), perfluorooctane (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA) maternal plasma samples. Mothers reported occurrence (yes/no) of chest infections, lower tract...
Background/Aim: Animal studies indicate that perfluoroalkyl substances (PFAS), including perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic (PFNA), may be neurotoxicants. Few birth cohorts have studied possible PFAS effects in child brain development longitudinally. We investigated the association between plasma concentrations at gestational week 12 neuropsychological throughout first 6 years of life. Methods: The study...