Cyntia B. Manzano-Salgado

ORCID: 0000-0003-1242-2318
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About
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Research Areas
  • Per- and polyfluoroalkyl substances research
  • Air Quality and Health Impacts
  • Birth, Development, and Health
  • Effects and risks of endocrine disrupting chemicals
  • Toxic Organic Pollutants Impact
  • Health, Environment, Cognitive Aging
  • Meta-analysis and systematic reviews
  • Statistical Methods in Clinical Trials
  • Data-Driven Disease Surveillance
  • Fluoride Effects and Removal
  • Nutritional Studies and Diet
  • Health Systems, Economic Evaluations, Quality of Life
  • Atmospheric Ozone and Climate
  • Gestational Diabetes Research and Management
  • Global Cancer Incidence and Screening
  • Colorectal Cancer Screening and Detection
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Obesity, Physical Activity, Diet
  • Climate Change and Health Impacts
  • Healthcare Systems and Technology

Barcelona Institute for Global Health
2016-2023

Universitat Pompeu Fabra
2015-2023

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015-2023

IQ Solutions
2021

IQVIA (United States)
2021

Universitat Autònoma de Barcelona
2019

Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2019

Center for Research in Environmental Epidemiology
2015-2017

Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.We evaluated the of urinary concentrations 24 chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide and cotinine, between weeks from different pregnancy trimesters pregnant women, days seasons children.154 women 152 children six European countries were enrolled 2014-2015. Pregnant provided three urine...

10.1016/j.envint.2018.09.046 article EN cc-by-nc-nd Environment International 2018-10-06

Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy a period of enhanced tissue plasticity fetus and mother be critical window PFAS exposure susceptibility.We evaluated associations between exposures outcomes in pregnant women.We analyzed 1,240 women from Spanish INMA [Environment Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with...

10.1289/ehp1062 article EN public-domain Environmental Health Perspectives 2017-11-01

Background: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce inconsistent. Objectives: We estimated associations between prenatal PFAS exposures outcomes relevant to risk, including a composite CM-risk score. Methods: measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) in maternal plasma (first trimester)....

10.1289/ehp1330 article EN public-domain Environmental Health Perspectives 2017-09-21

Electronic health records are becoming an increasingly valuable resource for epidemiology but their data quality needs to be quantified. We aimed validate twenty-five types of incident cancer cases in the Information System Research Primary Care (SIDIAP) Catalonia with population-based registries Girona and Tarragona as gold-standard.We calculated sensitivity, positive predictive values (PPV), time-difference between date diagnosis entered into SIDIAP registries. added hospital discharge...

10.2147/clep.s225568 article EN cc-by-nc Clinical Epidemiology 2019-12-01

Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied PFASs biometry.In 1230 mother-child pairs of three cohorts from Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) in first-trimester maternal plasma (collection: 2003-2008)....

10.1016/j.envint.2019.05.024 article EN cc-by-nc-nd Environment International 2019-06-25

Prenatal exposures to perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic (PFOA) have been associated with child health outcomes, but many of these associations remain poorly characterized. The aim this work was provide new indicators foetal exposure for the Spanish INMA birth cohort. First, a pregnancy lactation physiologically based pharmacokinetic (PBPK) model calibrated in population framework quantitative estimates PFOA PFOS placental transfers humans. estimated distributions...

10.1016/j.taap.2019.114640 article EN publisher-specific-oa Toxicology and Applied Pharmacology 2019-06-26

Results of studies on perfluoroalkyl substances (PFASs) and thyroid hormones (THs) are heterogeneous, the mechanisms underlying action PFASs to target THs have not been fully characterized. We examined relation between first-trimester maternal PFAS TH levels role played by polymorphisms in iodothyronine deiodinase 1 (

10.1021/acs.est.1c01452 article EN Environmental Science & Technology 2021-07-27

Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) may affect child growth; thus estimating PFAS fetal body burden is relevant. considered best estimated in cord samples; however previous cohort studies have used either maternal plasma or serum indistinctively during pregnancy as proxy. We evaluated the correlations and transfer ratio between concentration pregnancy, at birth a Spanish cohort. Methods: measured perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic...

10.1289/isee.2015.2015-1199 article EN ISEE Conference Abstracts 2015-08-20

Introduction: Perfluoroalkyl substance (PFAS) exposure has been associated with higher cardio-metabolic (CM) risk in adults but less evidence exists for children. We studied the effect of prenatal PFAS on CM at 4 and 7 years a Spanish birth cohort. Methods: measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) maternal plasma (2003-2008). At (n=1,200) (n=815) age, we assessed age-and sex-specific z-scores body mass...

10.1289/isee.2016.4216 article EN ISEE Conference Abstracts 2016-08-17

Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) may play a role in childhood obesity; however evidence from prospective studies is limited. We evaluated the effect of prenatal PFAS on postnatal rapid growth at 6 months life and overweight 4 years age Spanish birth cohort. Methods: assessed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) 1,234 maternal plasma samples collected 12 weeks pregnancy....

10.1289/isee.2015.2015-1261 article EN ISEE Conference Abstracts 2015-08-20

Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) might affect child health; but maternal determinants of PFAS are unclear. We evaluated whether socio-demographic and dietary factors predict concentrations during pregnancy in a birth cohort. Methods: analyzed the perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) 1,239 plasma samples at 10-13 weeks collected 2003-2008. Women also completed questionnaire...

10.1289/isee.2015.2015-1195 article EN ISEE Conference Abstracts 2015-08-20

Children exposure to per- and polyfluoroalkyl acids substances (PFAS) is a major concern in health risk assessment as early-life exposures are suspected induce adverse effects such cardiometabolic, neurodevelopmental, or impact on immune response. Our work aims estimate children PFOA PFOS using Physiologically-Based Pharmacokinetic (PBPK) modelling approach. A lifetime model for PFAS was updated simulate the internal during utero life childhood, include individual characteristics scenarios....

10.14293/p2199-8442.1.sop-.pqdevt.v1 preprint EN cc-by 2023-05-09

Prenatal exposure to perfluoroalkyl substances (PFAS) may be associated with impaired immune and respiratory health during childhood but the evidence is scarce inconsistent. We studied association between prenatal PFAS up age 7 years in Spanish INMA birth cohort (n=1188). assessed perfluorohexane sulfonate (PFHxS), perfluorooctane (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA) maternal plasma samples. Mothers reported occurrence (yes/no) of chest infections, lower tract...

10.1183/13993003.congress-2018.pa5016 article EN 2018-09-15

Background/Aim: Animal studies indicate that perfluoroalkyl substances (PFAS), including perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic (PFNA), may be neurotoxicants. Few birth cohorts have studied possible PFAS effects in child brain development longitudinally. We investigated the association between plasma concentrations at gestational week 12 neuropsychological throughout first 6 years of life. Methods: The study...

10.1289/isee.2017.2017-539 article EN ISEE Conference Abstracts 2018-02-01
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