A5064117981- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Potato Plant Research
- Per- and polyfluoroalkyl substances research
- Pesticide Exposure and Toxicity
- Heavy Metal Exposure and Toxicity
- Immunotoxicology and immune responses
- Contact Dermatitis and Allergies
- Plant Pathogens and Resistance
- Occupational exposure and asthma
- Indoor Air Quality and Microbial Exposure
- Advanced Chemical Sensor Technologies
- Pesticide and Herbicide Environmental Studies
- Recycling and Waste Management Techniques
- Animal testing and alternatives
- Sulfur Compounds in Biology
- Pharmacogenetics and Drug Metabolism
- Health, Environment, Cognitive Aging
- Amino Acid Enzymes and Metabolism
- Skin Protection and Aging
- Heavy metals in environment
- Asthma and respiratory diseases
- Environmental Toxicology and Ecotoxicology
RWTH Aachen University
2015-2024
Universitätsklinikum Aachen
2008-2024
Institut für Soziale Arbeit
2019-2023
FH Aachen
2012-2021
Faculty (United Kingdom)
2021
University of Udine
2015
American University of Armenia
2015
Institut Scientifique de Santé Publique
2015
Friedrich-Alexander-Universität Erlangen-Nürnberg
2001-2011
National Institute of Health Dr. Ricardo Jorge
2009
Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy a period of enhanced tissue plasticity fetus and mother be critical window PFAS exposure susceptibility.We evaluated associations between exposures outcomes in pregnant women.We analyzed 1,240 women from Spanish INMA [Environment Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with...
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL;...
Background: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce inconsistent. Objectives: We estimated associations between prenatal PFAS exposures outcomes relevant to risk, including a composite CM-risk score. Methods: measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) in maternal plasma (first trimester)....
Because of their dirt-, water- and oil-repelling properties, per- polyfluoroalkyl substances (PFASs) are frequently used in a broad variety consumer products. They have been detected human samples worldwide. In Flanders, Belgium, the Flemish Environment Health Studies (FLEHS) measured levels five PFAS biomarkers four different age groups population identified determinants variability exposure. Cord plasma or peripheric serum questionnaire data were available for 220 mother-newborn pairs...
Mitochondrial DNA (mtDNA) content and telomere length are putative aging biomarkers sensitive to environmental stressors, including pollutants. Our objective was identify, from a set of exposures, which exposure is associated with leukocyte mtDNA in adults. This study includes 175 adults 50 65 years old the cross-sectional Flemish Environment Health study, whom were determined using qPCR. The levels seven metals, 11 organohalogens, four perfluorinated compounds (PFHxS, PFNA, PFOA, PFOS)...
Abstract Mercapturic acids are highly important and specific biomarkers of exposure to carcinogenic substances in occupational environmental medicine. We have developed validated a reliable, very sensitive method for the simultaneous determination five mercapturic derived from several high‐production chemicals used industry, namely ethylene oxide, propylene acrylamide, acrolein N,N ‐dimethylformamide. Analytes enriched cleaned up urinary matrix by offline solid‐phase extraction. The...
In spring 2010, high internal exposures (up to 236 μg/L plasma) for the sum of indicator polychlorinated biphenyls (PCB) were discovered in workers a transformer recycling company Germany, where PCB-contaminated material was not handled according proper occupational hygiene. The release PCB from this raised growing concerns regarding possible adverse human health effects correlated with exposure. This provided basis large biological monitoring study order examine exposure individuals working...
Despite their long-term ban, persistent organochlorine compounds like hexachlorobenzene (HCB), p,p'-dichlorodiphenylethylene (DDE) as well polychlorinated biphenyls (PCBs) are still of environmental concern. For the evaluation potential occupational or exposures to these substances, it is essential know current background burden general population. As representative and up-to-date information missing for Germany, we have analysed a large dataset generated in studies on exposure lower...
Abstract Background The successive FLEHS campaigns assess internal exposure to pollutants and associated early biological health effects in participants of different age groups. Materials methods Mother–newborn pairs ( N = 220 2008–2009, 18–42 years; 269 2013–2014, 18–44 years), 197 adolescents 14–15 years (2010–2011), 201 adults 20–40 (2008–2009) 205 50–65 (2014) were recruited. For the various groups subjects sets PFAS assessed. Perfluorooctane sulfonate (PFOS), perfluorohexane (PFHxS),...