A5042972188- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Herpesvirus Infections and Treatments
- Paraoxonase enzyme and polymorphisms
- Birth, Development, and Health
- Cytomegalovirus and herpesvirus research
- Inhalation and Respiratory Drug Delivery
- Climate Change and Health Impacts
- Noise Effects and Management
- Virus-based gene therapy research
- Respiratory viral infections research
- Inflammasome and immune disorders
- Viral gastroenteritis research and epidemiology
- Indoor Air Quality and Microbial Exposure
- Carcinogens and Genotoxicity Assessment
- Hypothalamic control of reproductive hormones
- Pesticide and Herbicide Environmental Studies
- Heavy Metal Exposure and Toxicity
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Weed Control and Herbicide Applications
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Biologie des Oiseaux et Aviculture
2025
Flemish Institute for Technological Research
2014-2024
University of Antwerp
2013-2024
Infectiologie Animale et Santé Publique
2014-2024
Universidad de Granada
2023
Hôpital Paule de Viguier
2021
Université de Tours
2017-2020
Prenatal chemical exposure has been frequently associated with reduced fetal growth by single pollutant regression models although inconsistent results have obtained. Our study estimated the effects of to pollutants and mixtures on birth weight in 248 mother-child pairs. Arsenic, copper, lead, manganese thallium were measured cord blood, cadmium maternal methylmercury hair, five organochlorines, two perfluorinated compounds diethylhexyl phthalate metabolites plasma. Daily particulate matter...
As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This builds on existing HBM capacity by aligning national or regional studies. The targets 3 age groups (i) children aged 6-11 years, (ii) teenagers 12-19 years and (iii) young adults 20-39 includes total 9493 participants (3151 children, 2953 3389 adults). Depending group, internal exposure to phthalates substitute Hexamoll® DINCH, brominated organophosphorus...
In this review we discuss the novel developments in mass spectrometry-based analytical methods for size determination, chemical identification, and quantification of microplastic nanoplastic indoor air dust.
The purpose of this project report is to introduce the European “GOLIATH” project, a new research which addresses one most urgent regulatory needs in testing endocrine-disrupting chemicals (EDCs), namely lack methods for EDCs that disrupt metabolism and metabolic functions. These collectively referred as “metabolism disrupting compounds” (MDCs) are natural anthropogenic can promote changes ultimately result obesity, diabetes, and/or fatty liver humans. This introduces main approaches...
The Flemish Environment and Health Study (FLEHS) collects information on internal exposure to a broad range of environmental chemicals in the general population Flanders, Northern region Belgium. aim is establish biomonitoring distributions for support public health policy, risk assessment management decisions. In 2017-2018, urine blood samples were collected from 428 teenagers by stratified clustered two stage randomized design. Samples analyzed biomarkers related chlorinated newer...
Abstract Background The successive FLEHS campaigns assess internal exposure to pollutants and associated early biological health effects in participants of different age groups. Materials methods Mother–newborn pairs ( N = 220 2008–2009, 18–42 years; 269 2013–2014, 18–44 years), 197 adolescents 14–15 years (2010–2011), 201 adults 20–40 (2008–2009) 205 50–65 (2014) were recruited. For the various groups subjects sets PFAS assessed. Perfluorooctane sulfonate (PFOS), perfluorohexane (PFHxS),...
Perfluoroalkyl substances (PFAS) and phthalates are synthetic chemicals widely used in various types of consumer products. There is epidemiological experimental evidence that PFAS may alter thyroid hormone levels; however, studies children adolescents limited.To investigate the association exposure to phthalate with serum levels hormones European adolescents.A cross-sectional study was conducted 406 female 327 male (14-17 years) from Belgium, Slovakia, Spain participating Aligned Studies...
Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids tissues. Complementing exposure biomarkers with mechanistically based effect may further elucidate causal pathways between chemical and adverse health outcomes. We combined information on previously implemented human observational studies mechanisms action reported experimental from published Adverse Outcome Pathways (AOPs), focusing reproductive effects phthalate exposure....
Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM were collected from aligned studies at five sampling sites distributed over Europe (studies: SLO CRP (SI); ORGANIKO (CY); GerES V-sub (DE); 3XG (BE); ESTEBAN (FR)). Median Gly concentrations urine below or around detection limit (0.1 µg/L). The 95th percentiles ranged between 0.18 and 1.03 µg Gly/L. ratio AMPA (aminomethylphosphonic acid; main metabolite Gly) molar basis was average 2.2...
There is increasing epidemiologic evidence that arsenic exposure in utero associated with adverse pregnancy outcomes and may contribute to long-term health effects. These effects occur at low environmental exposures but the underlying molecular mechanism not clear. We collected cord blood samples of 183 newborns identify associations between levels birth anthropometric parameters an area very exposure. Our core research aim was screen for transcriptional marks mechanistically explain these...
Marek's disease is one of the most common viral diseases poultry affecting chicken flocks worldwide. The caused by an alphaherpesvirus, virus (MDV), and characterized rapid onset multifocal aggressive T-cell lymphoma in host. Although several oncogenes have been identified, detailed mechanisms underlying MDV-induced lymphomagenesis are still poorly understood. Many viruses modulate cell cycle progression to enhance their replication persistence host cell, case some oncogenic ultimately...
Abstract Zebrafish phenotypic assays have shown promise to assess human hepatotoxicity, though scoring of liver morphology remains subjective and difficult standardize. Liver toxicity in zebrafish larvae at 5 days was assessed using gene expression as the biomarker approach, complementary analysis analytical data on compound uptake. This approach aimed contribute improved hepatotoxicity prediction, with goal identifying biomarker(s) a step towards development transgenic models for...
Abstract Background PFAS are persistent, bioaccumulative compounds repelling water, oil and stains which widely used. There is mounting evidence linking exposure to a range of adverse health outcomes including renal, hepatic, immunotoxic, reproductive, endocrine disrupting carcinogenic effects. possibly also induce neurobehavioral developmental Within Flanders Environment Health Studies (FLEHS) internal relevant effects assessed since 2008. Results Adolescents 14–15 y (2010–2011) living in...
The gallid alphaherpesvirus 3 (GaAHV3) SB-1, a Mardivirus used as vaccine against Marek’s disease, has been proposed an interesting viral vector for poultry vaccination. However, SB-1 is highly transmissible between chickens, feature that may be limitation the use of live recombinant vaccines. We have previously shown UL47 essential horizontal transmission pathogenic disease virus but it completely dispensable replication and pathogenesis. In contrast, role in biology remains unknown. To...
Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic profile at school age. However, molecular mechanisms involved have not yet been resolved. It was hypothesized that epigenetics might be involved. The aim of present study therefore investigate whether DNA methylation patterns blood cells were related...
Kisspeptin has been proposed as an effect biomarker to understand the mechanisms by which some environmental chemicals adversely affect human reproductive system.To ascertain whether kisspeptin serum protein and DNA methylation levels are associated with exposure several (individually a mixture) hormone in adolescent males.Three phenols (bisphenol A [BPA], methyl-paraben [MPB], benzophenone-3 [BP3]); two toxic metals (arsenic cadmium); four metabolites of non-persistent pesticides, including...