A5048084951- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Health, Environment, Cognitive Aging
- Atmospheric Ozone and Climate
- Hearing Loss and Rehabilitation
- IL-33, ST2, and ILC Pathways
- Birth, Development, and Health
- Noise Effects and Management
- Heavy Metal Exposure and Toxicity
- Hearing, Cochlea, Tinnitus, Genetics
- Immune Cell Function and Interaction
- Chemical Analysis and Environmental Impact
- Folate and B Vitamins Research
- Human Health and Disease
- Stonefly species taxonomy and ecology
- Infant Nutrition and Health
- 3D Modeling in Geospatial Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Heavy Metals in Plants
- Health and Conflict Studies
- Mercury impact and mitigation studies
- Radioactivity and Radon Measurements
Slovak Medical University
2011-2024
Faculty of Public Health
2018
University of Bristol
2012
Carol Davila University of Medicine and Pharmacy
2012
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL;...
To determine demographic, reproductive, and maternal dietary factors that predict perfluoroalkyl substance (PFAS) concentrations in breast milk, we measured perfluorooctane sulfonic (PFOS) perfluorooctanoic acid (PFOA) concentrations, using liquid chromatography–mass spectrometry, 184 colostrum samples collected from women participating a cohort study Eastern Slovakia between 2002 2004. During their hospital delivery stay, mothers completed food frequency questionnaire, demographic...
Toxic equivalency factors (TEFs) are an important component in the risk assessment of dioxin-like human exposures. At present, this concept is based mainly on vivo animal experiments using oral dosage. Consequently, current TEFs derived from mammalian applicable only for exposure situations which ingestion occurs. Nevertheless, these "intake" commonly-but incorrectly-used by regulatory authorities to calculate "systemic" toxic equivalents (TEQs) blood and tissue concentrations, used as...
Perfluoroalkyl substances (PFASs) are man-made fluorinated compounds with endocrine-disrupting properties, detected in 99% of serum samples worldwide and associated adverse childhood health outcomes. The aim this study was to describe determinants prenatal exposure PFASs Slovakia. This based on Slovak multicentric prospective mother-child cohort PRENATAL (N = 796). Cord blood were collected within 2010–2012 analyzed a subpopulation 322 newborns. Concentrations perfluorooctane sulfonic acid...
Over the years eastern Slovakia has been subject to consistent monitoring of high levels polychlorinated biphenyls (PCBs) in both environment and human populations attributed former production PCBs at Chemko Strážske plant. We aimed investigate extent which dietary habits residential location could affect concentrations blood serum samples subjects.
Summary This cross-sectional study was designed to investigate the extent of genetic susceptibility by targeting variants in interleukin (IL)−4/IL-13 signalling pathways leading atopic disease early childhood. We evaluated involvement five single nucleotide polymorphisms IL4 C-590T, IL13 C-1055T, Arg130Gln, IL4RA Ile50Val and Gln576Arg, control serum total antigen-specific immunoglobulin (Ig)E levels. Furthermore, we analysed their association with changes gene expression cytokines having...
Introduction: Pollutants as the polychlorinated biphenyls (PCBs), dibenzofurans and some organochlorine pesticides are ototoxic to humans. The aim was identify sensitive windows of perinatal PCB exposure. Methods: A total 351 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 72 months age. Cord child 6-, 16-, 45-, 72- month blood samples were analyzed for 153 concentrations. DPOAEs 11 frequencies grouped into 5 groups. concentration-time profiles...
In toxicological studies of environmental chemicals with markedly changing concentration in the system time it has often to be decided whether health outcome should related single point concentration, peak or an integrated over (area under curve (AUC)). We compared these three approaches when studying 181 children, living eastern Slovakia highly polluted by locally produced PCBs past, association between serum leptin level determined at age 7 years and exposure PCB 153. 153 was measured cord...
Background Human milk is an important carrier of PCBs and lactational transfer represents the primary route PCB exposure to developing mammals. A measure infants amount taken up into body, commonly considered be a product concentration compound in rate consumption breast or alternately duration feeding. This approach accompanied by many uncertainties originating from reporting on exclusivity Aims To create valid relationship between 153 serum fed infant feeding minimalize influence reported...
Background Adipocytes secrete metabolically active proteins known as adipokines, the major ones being leptin and adiponectin. Leptin is regulator of food intake energy expenditure at hypothalamus level, it affects tissues several neuroendocrine axes. Adiponectin one key molecules in metabolic syndrome, regulates insulin sensitivity hepatic glucose production. There raising concern about influence chemical exposures on obesity role environmental exposure to endocrine disruptors alteration...
PP-31-119 Background/Aims: Michalovce region in the Eastern Slovakia was characterized by intense polychlorinated biphenyls (PCB) production within 1959–1984; although it stopped 80s, substantial environmental PCB contamination still exists. We assessed effect of prenatal exposure on thyroid functions mothers with newborns born Michalovce. Methods: Mothers (N = 220) were recruited after hospital admission for delivery, and samples maternal cord blood sera collected. Concentrations hormones...
Patayova, Henrieta; Palkovicova, Lubica; Rausova, Katarina; reichrtova, Eva; Stoian, Irina; Sounders, Margaret; Ursínyova, Monika; Kocan, Anton; Wimmerova, Sona Author Information