A5076197399- Epigenetics and DNA Methylation
- Carcinogens and Genotoxicity Assessment
- Ocular Oncology and Treatments
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Histone Deacetylase Inhibitors Research
- Folate and B Vitamins Research
- Cancer-related gene regulation
- Advances in Oncology and Radiotherapy
- Nanoparticles: synthesis and applications
- Antioxidant Activity and Oxidative Stress
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Acute Lymphoblastic Leukemia research
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Nutritional Studies and Diet
- RNA modifications and cancer
- RNA Interference and Gene Delivery
Biomedical Research Center of the Slovak Academy of Sciences
2016-2025
Cancer Research Institute of the Slovak Academy of Sciences
2016-2025
Slovak Academy of Sciences
2014-2024
Molecular Oncology (United States)
2020-2023
Slovak Medical University
1998-2017
Cancer Genetics (United States)
2012-2015
German Cancer Research Center
2014
Heidelberg University
2014
Eskişehir Osmangazi University
2012
St. Paul's Hospital
2001
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate risk overall mortality, mortality by cause, cancer incidence associated damage, cohort 2,403 healthy individuals (25,978 person-years) screened 16 laboratories using between 1996 2016 was followed-up. Kaplan-Meier analysis indicated worse survival medium high tertile damage (p < 0.001). effect on modelled according...
Recent evidence in cancer research, developed the notion that malignant tumors consist of different subpopulations cells, one them, known as stem being attributed many important properties such enhanced tumorigenicity, proliferation potential and profound multidrug resistance to chemotherapy. Several key cells markers were identified colon cancer. In our study we focused on aldehyde dehydrogenase type 1 (ALDH1) expression cancer-derived cell lines HT-29/eGFP, HCT-116/eGFP LS-180/eGFP, its...
Breast cancer comprises a substantial proportion of diagnoses in women and is primary cause cancer-related mortality. While hormone-responsive cases generally have favorable prognosis, the aggressive nature triple-negative breast presents challenges, with intrinsic resistance to established treatments being persistent issue. The complexity intensifies emergence acquired resistance, further complicating management cancer. Epigenetic changes, encompassing DNA methylation, histone RNA...
Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns sensitize cells other therapies, provide a new treatment strategy for drug-resistant tumors. Here we investigated the ability DNA methyltransferase (DNMT) inhibitor decitabine (DAC) increase sensitivity BC anthracycline antibiotic doxorubicin (DOX). Three cell lines representing different...
The aim of this study was to investigate the relationship between promoter methylation in five cancer-associated genes and clinicopathologic features for identification molecular markers tumor metastatic potential hormone therapy response efficiency breast cancer. levels paraffin-embedded tissues, plasma, blood cells from 151 sporadic cancer patients samples 50 controls were evaluated by quantitative multiplex methylation-specific polymerase chain reaction. DNA RAS-association domain family...
Breast carcinoma is the most common cancer with high mortality caused by metastatic disease.New molecular biomarkers predicting tumour's potential would therefore improve metastasis prevention and personalised care.The aim of study was to investigate relationship between DNA methylation levels in invasivity metastasising associated genes aberrant protein expression also evaluate whether a similar level present tumour circulating cell-free for utilising plasma as prognostic biomarker.By using...
Cisplatin resistance in testicular germ cell tumors (TGCTs) is a clinical challenge. We investigated the underlying mechanisms associated with cancer stem (CSC) markers and modalities circumventing chemoresistance. Chemoresistant models (designated as CisR) of human embryonal carcinoma lines NTERA-2 NCCIT were derived characterized using flow cytometry, gene expression, functional protein arrays. Tumorigenicity was determined on immunodeficient mouse model. Disulfiram used to examine...
Deregulated expression of microRNAs has the oncogenic or tumor suppressor function in cancer. Since miRNAs plasma are highly stable, their quantification could contribute to more precise cancer diagnosis, prognosis and therapy prediction. We have quantified seven oncomiRs, namely miR-17/92 cluster (miR-17, miR-18a, miR-19a miR-20a), miR-21, miR-27a miR-155, 137 breast (BC) patients. detected down-regulation six patients with invasive BC compared controls; however, only miR-20a...
Recently, we reported about exosomes possessing messenger RNA (mRNA) of suicide gene secreted from mesenchymal stem/stromal cells (MSCs) engineered to express the gene-fused yeast cytosine deaminase::uracil phosphoribosyltransferase (yCD::UPRT). The yCD::UPRT-MSC are internalized by tumor and intracellularly convert prodrug 5-fluorocytosine (5-FC) cytotoxic drug 5-fluorouracil (5-FU). Human with potential metastasize release involved in creation a premetastatic niche at predicted organs. We...
Aims: Chemotherapy resistance remains a major challenge in breast cancer (BC) treatment. This study investigated whether development is associated with DNA methylation changes and assessed the potential of methyltransferase inhibitor decitabine (DAC) to reverse these alterations enhance chemosensitivity. Methods: Molecular profiling functional assays were used characterize paclitaxel- (PAC) doxorubicin- (DOX) resistant BC cell lines derived from luminal A (T-47D), triple-negative...