A5014325801- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- Electromagnetic Fields and Biological Effects
- Advanced Glycation End Products research
- Bioactive Compounds and Antitumor Agents
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Microbial Natural Products and Biosynthesis
- Terahertz technology and applications
- Dialysis and Renal Disease Management
- Genetically Modified Organisms Research
- Acute Lymphoblastic Leukemia research
- Plant Toxicity and Pharmacological Properties
- Microtubule and mitosis dynamics
- Marine Sponges and Natural Products
- CRISPR and Genetic Engineering
- Synthesis and Biological Evaluation
- Molecular Biology Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Diet and metabolism studies
University of Würzburg
2016-2025
Universitätsklinikum Würzburg
2020-2023
Institute of Pharmacology
1993-2021
Bayer (Germany)
2002
Fresenius Medical Care North America (United States)
2001
Fresenius Medical Care (Germany)
2001
Chirurgische Universitätsklinik Heidelberg
2001
KfH Kuratorium für Dialyse und Nierentransplantation
1999-2001
In-Q-Tel
2000
University of Rostock
1995
Abstract DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine, Vidaza) has recently been approved as an antitumor agent, and others are presently in various stages their preclinical or clinical development. Most the archetypal have established characterized different experimental systems, which thus far precluded direct comparison. We now defined conditions that allowed a comparative analysis six most widely known...
Bone marrow stromal cells (BMSCs) and other cell populations derived from mesenchymal precursors are developed for cell-based therapeutic strategies undergo cellular stress during ex vivo procedures. Reactive oxygen species (ROS) of environmental origin involved in redox signaling, cumulative damage, senescence, tumor development. Selenium-dependent (glutathione peroxidases [GPxs] thioredoxin reductases [TrxRs]) selenium-independent (superoxide dismutases [SODs] catalase [CAT]) enzyme...
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate risk overall mortality, mortality by cause, cancer incidence associated damage, cohort 2,403 healthy individuals (25,978 person-years) screened 16 laboratories using between 1996 2016 was followed-up. Kaplan-Meier analysis indicated worse survival medium high tertile damage (p < 0.001). effect on modelled according...
The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which give rise false positive results in the assay. Systematic studies on genotoxins cytotoxins (i.e. non-genotoxic poisons) have attempted establish a threshold death measured could be regarded as result. Thresholds cytotoxicity/cell range from 20% 50% various publications. Curiously, survey latest literature culture suggests that...
Biomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens, may enable the detection damage and early disease prevention. In recent years, comet assay has become an important tool for assessing DNA damage, both in environmental occupational exposure contexts. To evidence role biomonitoring, we have analysed original research studies used their assessments, following PRISMA-ScR method (preferred reporting items systematic reviews...
Abstract Background Complications in diabetes mellitus are partially mediated by enhanced formation of reactive oxygen species. Among the factors involved species formation, advanced glycation end products play a key role. Owing to reduced activity enzyme transketolase, which requires diphosphorylated thiamine (vitamin B 1 ) as cofactor, an accumulation those deleterious glucose metabolites especially diabetic patients can be observed. Benfotiamine, lipophilic diphosphate prodrug, prevented...
Diazepinomicin is a dibenzodiazepine alkaloid with an unusual structure among the known microbial metabolites discovered so far. was isolated from marine sponge-associated strain Micromonospora sp. RV115 and identified by spectroscopic analysis comparison to literature data. In addition its interesting preclinical broad-spectrum antitumor potential, we report here new antioxidant anti-protease activities for this compound. Using ferric reducing power (FRAP) assay, strong potential of...
Epidemiological studies exploring the connection between hypertension and cancer demonstrate a higher incidence, especially of kidney cancer, mortality in hypertensive patients. Hormones elevated hypertension, i.e., aldosterone angiotensin II, which exert genotoxic effects vitro, could contribute to carcinogenesis hypertension. The present study was conducted investigate possible DNA-damaging effect receptor activation vivo. Crl:CD (Sprague-Dawley) rats were treated for 6 wk with...
Effects of electromagnetic fields on biological systems all levels, ranging from isolated biomolecules to whole organisms, have been investigated comprehensively for a long time. Due lack suitable sources and detectors, the terahertz frequency range has not same amount as other frequencies. Even though early reports date back 1960s, thorough research only conducted during last decade. The aim this review is give summary available publications topic. A comprehensive literature was resulting...