A5006970882- Nicotinic Acetylcholine Receptors Study
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Land Use and Ecosystem Services
- Urban Planning and Valuation
- Vector-Borne Animal Diseases
- Drug Transport and Resistance Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- DNA and Nucleic Acid Chemistry
- Cell death mechanisms and regulation
- Hepatitis B Virus Studies
- DNA Repair Mechanisms
- Cancer Research and Treatments
- Receptor Mechanisms and Signaling
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Synthesis and Biological Evaluation
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Geographic Information Systems Studies
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2013-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2025
San Raffaele University of Rome
2018-2025
Vita-Salute San Raffaele University
2021-2025
Università Cattolica del Sacro Cuore
2008-2023
IRCCS Ospedale San Raffaele
2010-2021
University of Catania
2008-2020
The University of Melbourne
2013-2017
CRC for Spatial information
2017
Children's Hospital of Philadelphia
2005-2013
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate risk overall mortality, mortality by cause, cancer incidence associated damage, cohort 2,403 healthy individuals (25,978 person-years) screened 16 laboratories using between 1996 2016 was followed-up. Kaplan-Meier analysis indicated worse survival medium high tertile damage (p < 0.001). effect on modelled according...
Abstract This study presents data suggesting that both human mesothelioma (cell lines and biopsies) normal mesothelial cells express receptors for acetylcholine stimulation of these by nicotine prompted cell growth via activation nicotinic cholinergic receptors. Thus, demonstrate that: (a) biopsies as well pleural functionally α-7 acethlycholine receptors, evaluated α-bungarotoxin-FITC binding, receptor binding assay, Western blot, reverse transcription-PCR; (b) choline acetyltransferase...
Sixteen aromatic amines and azo-derivatives were studied. They were: benzidine; 2-acetylaminofluorene; 3'-methyl-p-dimethylaminobenzene; o-aminoazo-toluene; p-dimethylaminoazobenzene; 2,4-diamino-toluene; 4,4'-oxydianiline; 2,4-diaminoanisole; 4,4'-methylenedianiline; 2-naphthylamine; Auramine O; Rhodamine B; Ponceau MX; 1-naphthylamine; p-aminoazobenzene aniline. The compounds examined for their capability to induce alkaline DNA fragmentation in rat liver after treatment vivo, mutagenicity...
Objectives : Lung cancer is the most common cause of death in world. Cigarette smoking represents major risk factor. Nicotine, an active component cigarettes, can induce cell proliferation, angiogenesis and apoptosis resistance. All these events are mediated through nicotinic acetylcholine receptor (nAChR) expressed on lung cells. We speculate that new insights into pathophysiological roles nAChR may lead to therapeutic avenues reduce non‐small (NSCLC) tumour growth. Materials methods Human...
The coronavirus disease 2019 (COVID-19) pandemic has a variable degree of severity according to underlying comorbidities and life-style. Several research groups have reported an association between cigarette smoking increased COVID-19. exact mechanism action is largely unclear. We exposed low angiotensin-converting enzyme 2 (ACE2)-expressing human pulmonary adenocarcinoma A549 epithelial cells nicotine assessed ACE2 expression at different times. further used the nicotine-exposed in virus...