A5037732910- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Advanced X-ray and CT Imaging
- Nonmelanoma Skin Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Cutaneous Melanoma Detection and Management
- Brain Metastases and Treatment
- Molecular Communication and Nanonetworks
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Brain Tumor Detection and Classification
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Gastrointestinal disorders and treatments
- Shoulder Injury and Treatment
- Cancer Risks and Factors
- Radiation Effects and Dosimetry
- MRI in cancer diagnosis
Agostino Gemelli University Polyclinic
2018-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
Advanced Radiation Therapy (United States)
2020
Università Cattolica del Sacro Cuore
2006-2018
Azienda Ospedaliero-Universitaria Careggi
2018
Università Campus Bio-Medico
2007-2016
A method for the in vivo determination of isocenter dose, , and mid‐plane using transmitted signal measured by 25 central pixels an aSi‐based EPID is here reported. The has been applied to check conformal radiotherapy pelvic tumors supplies accurate dosimetry avoiding many disadvantages associated with use two diode detectors (at entrance exit patient) as their periodic recalibration positioning. Irradiating water‐equivalent phantoms different thicknesses, a set correlation functions were...
Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, thicker than mm may be treated by IRT. The use image guidance in defining actual treating to correctly identify clinical target volume (CTV) prevent unnecessary toxicity paramount importance....
This work reports the results of application a practical method to determine in vivo dose at isocenter point, D(iso), brain thorax and pelvic treatments using transit signal S(t). The use stable detector for measurement S(t) (obtained by x-ray beam transmitted through patient) reduces many disadvantages associated with solid-state detectors positioned on patient as their periodic recalibration, positioning is time consuming. makes set correlation functions, obtained ratio between mid-plane...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of gastrointestinal tract. The main treatment for localized is surgical resection. These respond poorly to conventional cytotoxic chemotherapy agents and radiotherapy. Imatinib mesylate, a small-molecule kinase inhibitor, has proved useful in recurrent or metastatic GISTs now being tested adjuvant neoadjuvant setting. role radiotherapy management patients with GIST currently restricted symptomatic palliation....
The article reports a feasibility study about the potentiality of an in vivo dosimetry method for adaptive radiotherapy lung tumors treated by 3D conformal techniques (3D CRTs). At moment image guided (IGRT) has been used this aim, but it requires taking many periodic radiological images during treatment that increase workload and patient dose. In reported here can reduce above efforts, alerting medical staff commissioning new eventual plan. applied on 20 patients makes use transit signal...
Purpose To evaluate the performance of eleven Knowledge-Based (KB) models for planning optimization (RapidPlan tm (RP), Varian) Volumetric Modulated Arc Therapy (VMAT) applied to whole breast comprehensive nodal stations, internal mammary and/or supraclavicular regions. Methods and materials Six RP have been generated trained based on 120 VMAT plans data set with different criteria. Two extra-structures were delineated: a PTV ring structure. Five more models, twins previous created without...
A method for the determination of in vivo isocenter dose, D(iso), has been applied to dynamic conformal are therapy (DCAT) thoracic tumors. The makes use transmitted signal, S(t,alpha), measured at different gantry angles, a, by a small ion chamber positioned on electronic portal imaging device. is implemented set correlation functions obtained ratios between signal and midplane dose solid phantom, irradiated static fields. dosimetry DCAT requires convolution signals, reconstruction factors,...
This work reports a practical method for the determination of in vivo breast middle dose value, D(m) on beam central axis, using signal S(t), obtained by small thimble ion chamber positioned at center electronic portal imaging device, and irradiated x-ray transmitted through patient. The use stable reduces many disadvantages associated with diodes as their periodic recalibration positioning is time consuming. makes set correlation functions ratios S(t)/D(m), determined irradiating...
Magnetic resonance-guided adaptive radiotherapy (MRgART) is considered a promising resource for pancreatic cancer, as it allows to online modify the dose distribution according daily anatomy. This study aims compare dosimetric performance of simplified optimizer implemented on MR-Linac treatment planning system (TPS) with those obtained using an advanced conventional Linac.Twenty patients affected by locally cancer (LAPC) were considered. Gross tumor volume (GTV) and surrounding organ at...
The possibility of intentionally triggering non targeted effects (NTEs) using spatially fractionated radiotherapy (SFRT) alone or combined with immunotherapy is an intriguing and fascinating area research. Among different techniques for SFRT, stereotactic body targeting exclusively the central hypoxic segment bulky tumors, (SBRT-PATHY) might trigger immunogenic cell death more efficiently. This in silico study aims to identify best possible dosimetric trade-off prescribing SFRT volumetric...
Objective: To develop an alternative three-dimensional treatment plan with standardized fields class solution for whole-breast radiotherapy in patients large/pendulous breast and/or high body mass index (BMI). Methods: Two plans [tangential and five-fields technique (S5F)] a total dose of 50 Gy/25 fractions were generated large breasts [planning target volume (PTV) >1000 cm3 BMI >25 kg m−2], supine positioned. S5F consist two wedged tangential beams, anteroposterior: 20° the right 340° left...