A5072917079- Carcinogens and Genotoxicity Assessment
- Occupational exposure and asthma
- Effects and risks of endocrine disrupting chemicals
- Indoor Air Quality and Microbial Exposure
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Advanced Chemical Sensor Technologies
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- DNA Repair Mechanisms
- Air Quality and Health Impacts
- Contact Dermatitis and Allergies
- Analytical Chemistry and Chromatography
- Biomedical and Chemical Research
- Chemical Safety and Risk Management
- Toxic Organic Pollutants Impact
- Arsenic contamination and mitigation
- Analytical chemistry methods development
- Pesticide Residue Analysis and Safety
- Advancements in Transdermal Drug Delivery
- Chromium effects and bioremediation
- Occupational and environmental lung diseases
- Odor and Emission Control Technologies
- Nanoparticles: synthesis and applications
- Aluminum toxicity and tolerance in plants and animals
Karlsruhe Institute of Technology
2016-2025
Hvidovre Hospital
2025
Copenhagen University Hospital
2025
Deutsche Forschungsgemeinschaft
2017-2024
Kentucky imaging Technologies (United States)
2024
Leibniz Research Centre for Working Environment and Human Factors
2017-2023
TU Dortmund University
2017-2023
German Insurance Association
2018
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2017
Ludwig-Maximilians-Universität München
2017
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Compounds of nickel(II) and cadmium(II) are carcinogenic to humans experimental animals. One frequently discussed mechanism involved in tumor formation is an increase reactive oxygen species by both metals with the subsequent generation oxidative DNA damage. In present study we used human HeLa cells investigate potential induce lesions typical for free radicals intact effect on their repair. As indicators damage, determined frequencies strand breaks recognized bacterial...
The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up to resolve the problems associated with measurement of background levels oxidative damage (in particular 8-oxo-7,8-dihydroguanine, or 8-oxoGua) in human cells. A tendency for oxidation occur during sample preparation prior chromatography has been recognized as source a very substantial artefact. To assess success attempts eliminate artefact, ESCODD distributed its members standard samples pig liver and HeLa cells...
Even though a well-known human carcinogen the underlying mechanisms of arsenic carcinogenicity are still not fully understood. For arsenite, proposed interference with DNA repair processes and an increase in reactive oxygen species. less is known about genotoxic potentials its methylated metabolites monomethylarsonous [MMA(III)] dimethylarsinous [DMA(III)] acid, monomethylarsonic [MMA(V)] dimethylarsinic [DMA(V)] acid. Within present study we compared induction oxidative damage by arsenite...
Since the publication of International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number publications addressing test strategies mutagenicity. assessments substances with regard to genotoxicity are generally based combination tests assess effects three major end points genetic damage associated human disease: gene mutation, clastogenicity and aneuploidy. It is now clear from results international collaborative studies large databases...
Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts antimicrobial additives. This increases the risk of adverse health effects, since ions cytotoxic under overload conditions.The extra- and intracellular bioavailability NP MP were explored. In addition, different endpoints related to cytotoxicity well direct indirect genotoxicity oxides chloride (CuCl2) compared.Comprehensively characterized analysed regarding their ion release in model fluids....
This investigation aims to explore determinants of exposure particle size-specific welding fume. Area sampling ultrafine particles (UFP) was performed at 33 worksites in parallel with the collection respirable particles. Personal and inhalable carried out breathing zone 241 welders. Median mass concentrations were 2.48 mg m(-3) for 1.29 when excluding 26 users powered air-purifying respirators (PAPRs). Mass highest flux-cored arc (FCAW) gas applied (median particles: 11.6 m(-3))....
The post-translational modification poly(ADP-ribosyl)ation (PARylation) plays key roles in genome maintenance and transcription. Both non-covalent poly(ADP-ribose) binding covalent PARylation control protein functions, however, it is unknown how the two modes of crosstalk mechanistically. Employing tumor suppressor p53 as a model substrate, this study provides detailed insights into interplay between unravels its functional significance regulation p53. We reveal that multifunctional...
Even though epidemiological studies have identified arsenic compounds as carcinogenic to humans, they are not mutagenic in bacterial and mammalian test systems. However, increase the mutagenicity clastogenicity combination with other DNA damaging agents there indications of inhibition repair processes. We investigated effect arsenic(III) on nucleotide excision (NER) after UV irradiation human fibroblasts detail by using two repair-proficient one partly repair-deficient xeroderma pigmentosum...