A5069678876- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Heavy Metal Exposure and Toxicity
- Historical, Literary, and Cultural Studies
- Air Quality and Health Impacts
- Linguistic research and analysis
- Linguistics and language evolution
- Linguistic Education and Pedagogy
- Head and Neck Cancer Studies
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- BRCA gene mutations in cancer
- Lymphoma Diagnosis and Treatment
- Linguistics, Language Diversity, and Identity
- Health and Medical Studies
- Immune Cell Function and Interaction
- Trace Elements in Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chinese history and philosophy
- Allergic Rhinitis and Sensitization
- Sleep and Work-Related Fatigue
- Parkinson's Disease Mechanisms and Treatments
Institute for Prevention and Occupational Medicine
2014-2024
Ruhr University Bochum
1996-2014
Charité - Universitätsmedizin Berlin
2012-2013
Krebsregister Saarland
2005
Universitäts-Augenklinik Bonn
2004
National Cancer Registry
2001
National University of Singapore
2000
University of Münster
1999
University Hospitals of the Ruhr-University of Bochum
1997
St. Josef-Hospital
1997
This investigation aims to explore determinants of exposure particle size-specific welding fume. Area sampling ultrafine particles (UFP) was performed at 33 worksites in parallel with the collection respirable particles. Personal and inhalable carried out breathing zone 241 welders. Median mass concentrations were 2.48 mg m(-3) for 1.29 when excluding 26 users powered air-purifying respirators (PAPRs). Mass highest flux-cored arc (FCAW) gas applied (median particles: 11.6 m(-3))....
Background We compared psychomotor vigilance in female shift workers of the Bergmannsheil University Hospital Bochum, Germany (N = 74, 94% nurses) after day and night shifts. Methods Participants performed a 3-minute Psychomotor Vigilance Task (PVT) test bout at end two consecutive three shifts, respectively. was analyzed with respect to mean reaction time, percentage lapses false starts, throughput as an overall performance score, combining time error frequencies. also determined...
In this study we evaluate the suitability of two methods RNA conservation in blood samples, PAXgene and RNAlater, combination with variable shipping conditions for their application multicenter studies biobanking. yield, integrity, purity as well levels selected mRNA microRNA species were analyzed peripheral human samples stabilized by or RNAlater shipped on dry ice at ambient temperatures from centers to central analysis laboratory. Both examined systems clearly appropriate stabilization...
The use of circulating microRNAs as biomarkers has opened new opportunities for diagnosis cancer because exhibit tumor-specific expression profiles. aim this study was the identification in human plasma potential malignant mesothelioma. For discovery, TaqMan Low Density Array Human MicroRNA Cards were used to analyze 377 samples from 21 mesothelioma patients and asbestos-exposed controls. verification, individual microRNA assays quantitative real-time PCR 22 44 miR-132-3p showed different...
Abstract Malignant mesothelioma (MM) is strongly associated with a previous asbestos exposure. To improve timely detection of MM in workers, better screening tools – like minimally-invasive biomarkers are desirable. Between 2008 and 2018 2,769 patients benign asbestos-related diseases were recruited to participate annual screens. Using nested case-control design the protein markers calretinin mesothelin determined by enzyme-linked immunosorbent assays prediagnostic plasma samples 34 cases as...
Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With latency period up 50 years the incidence of MM still increasing, even in countries that banned Secondary prevention has been established provide persons at risk regular health examinations. An earlier detection with tumor markers might improve therapeutic options. Previously, we have developed new blood-based assay for protein marker calretinin. Aim this study was verification an independent...
We took advantage of magnetic resonance imaging (MRI) and spectroscopy (MRS) as non-invasive methods to quantify brain iron neurometabolites, which were analyzed along with other predictors motor dysfunction in Parkinson’s disease (PD). Tapping hits, tremor amplitude, the scores derived from part III Movement Disorder Society-Sponsored Revision Unified Parkinson Disease Rating Scale (MDS-UPDRS3 scores) determined 35 male PD patients controls. The iron-sensitive MRI relaxation rate R2* was...
Exposure to hexavalent chromium (Cr(VI)) has been primarily studied in chromate production. Here, we measured personal exposure respirable Cr(VI) together with airborne and urinary Cr Ni welders explore levels associations between various measures of exposure. Shift concentrations Cr(VI), Cr, were welding fumes 50 men who used either gas metal arc (GMAW) (n = 24) or tungsten inert (TIG) 19) as their major technique. determined pre- post-shift urine samples. Concentrations below the limit...
Malignant mesothelioma is an aggressive cancer of the serous membranes. For detection tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating miR-132-3p, miR-126-3p, and miR-103a-3p were analyzed in a nested case–control study using plasma samples from 17 prediagnostic cases 34 matched asbestos-exposed controls without malignant disease. Using collected median 8.9 months prior clinical diagnosis revealed 0% sensitivity on defined specificity 98%. Thus, miRNAs...
Abstract Background Asbestos causes mesothelioma and lung cancer. In the European Union, asbestos was banned in 2005, but it is still use many other countries. The aim of this study to estimate cancer incidence risk men with benign asbestos‐related or pleural diseases. Methods Between 2008 2018, 2439 male participants a German surveillance program for workers were included cohort. All had recognized occupational disease pleura lung. We estimated risks by calculating standardized ratios (SIR)...
Cortisol typically peaks in the morning after waking up and declines throughout day, reaching its lowest levels during nighttime sleep. Shift work can cause misalignment between cortisol sleep-wake timing. We analyzed this female shift workers focusing on timing extent of these changes.
The purpose of this study was to determine the prevalence BRCA1 mutations in Chinese breast cancer patients Singapore. analysis conducted consecutive with before age 40 years (76 women), or whose relatives had ovarian (16 women). Ten both early onset and affected relatives. Genomic DNA from peripheral mononuclear blood cells studied by using protein transcription–translation assay (exon 11) single-strand conformational polymorphism, subsequent sequencing. All six disease-causing occurred...
We aimed to prospectively evaluate the efficacy of a multi-modal surveillance programme for early detection familial breast cancer. Ultrasound, mammography and magnetic resonance imaging were evaluated in 413 women who participated prospective study with median follow-up 2.2 years (range 1–6.75 years). Of these, 49 carried BRCA mutation, 203 at high 161 moderate risk. Breast carcinomas diagnosed within compared 297 previously observed risk group 7894 documented regional cancer registry same...
It was the aim of this study to evaluate effect different devices on metal concentration in exhaled breath condensate (EBC) and prove whether working conditions welding companies result diverse composition metallic elements. The influence two collection (ECoScreen, ECoScreen2) detection elements EBC evaluated 24 control subjects. Properties ECoScreen a frequent use can alter content due contamination from components. ECoScreen2 turned out be favourable for assessment. Concentrations iron,...
Concerning possible harmful components of welding fumes, besides gases and quantitative aspects the respirable particle-inherent metal toxicity has to be considered.The objective this study was investigate effect markers leukotriene B4 (LTB4),prostaglandin E2 (PGE2) 8-isoprostane (8-Iso PGF2α) as well acid–base balance(pH) in exhaled breath condensate (EBC) 43 full-time gas arc welders (20 smokers) relation fume exposure. We observed different patterns iron, chromium nickel fumes EBC....