A5041688548- Asthma and respiratory diseases
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Advanced Chemical Sensor Technologies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Olfactory and Sensory Function Studies
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Occupational and environmental lung diseases
- Infection Control and Ventilation
- Climate Change and Health Impacts
- Lung Cancer Diagnosis and Treatment
- Contact Dermatitis and Allergies
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Pleural and Pulmonary Diseases
- Behavioral Health and Interventions
- Injury Epidemiology and Prevention
- Health and Medical Studies
- Transplantation: Methods and Outcomes
- Pediatric health and respiratory diseases
Institute for Prevention and Occupational Medicine
2016-2025
Ruhr University Bochum
2007-2014
Medizinische Hochschule Hannover
1995-2000
Das Lungenkarzinom ist mit jährlich über 40 000 Sterbefällen in der Bundesrepublik Deutschland die vierthäufigste Todesursache und häufigste Krebstodesursache [1]. Trotz Fortschritte Diagnostik Therapie liegt 5-Jahres-Überlebensrate Patienten europäischen nordamerikanischen Ländern nur einem Bereich von 5,5 – 15,7 % [2] [3]. Ziel vorliegenden Leitlinie Verbesserung Prognose Lebensqualität Lungenkarzinomen durch Optimierung des Einsatzes derzeitigen diagnostischen therapeutischen...
This abridged version is based on an interdisciplinary guideline which corresponds to development stage 3 (S3) of guidelines according the classification Association Scientific Medical Societies in Germany (AWMF). The process characterized by combination formal evidence-search, consensus, logic (algorithms), decision and outcome analysis, with cooperation 15 German Austrian medical societies. [Table 1] shows relationship between levels evidence, resulting recommendation grades...
Die vorliegende Kurzfassung basiert auf einer interdisziplinären Leitlinie, die der Entwicklungsstufe 3 (S3) Leitlinien nach Klassifikation Arbeitsgemeinschaft Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) entspricht und durch Kombination von formaler Evidenz-Recherche, Konsensfindung, Logik (Algorithmen), Entscheidungs- Outcome-Analyse sowie interdisziplinärem Abgleich unter Beteiligung 15 deutschen österreichischen medizinischen gekennzeichnet ist. [Tab. 1] zeigt Beziehung...
Abstract The use of face masks became mandatory during SARS-CoV-2 pandemic. Wearing may lead to complaints about laboured breathing and stress. influence different on cardiopulmonary performance was investigated in a partially double-blinded randomized cross-over design. Forty subjects (19–65 years) underwent body plethysmography, ergometry, exercise test 4-h wearing period without mask, with surgical mask (SM), community (CM), an FFP2 respirator (FFP2). Cardiopulmonary, physical,...
In this paper we report that interferon-gamma (IFN-gamma) maintains and enhances functional properties of terminally differentiated polymorphonuclear cells (PMN). Such effects are obvious when compared with untreated PMN declining in their response. Culture for 18 hr 100 IU/ml recombinant IFN-gamma resulted the expression about 15,000 Fc gamma RI per PMN. maintained viability prevented reduction RIIIb caused by apoptosis. No alterations were found level RIIa. Next, evaluated. Calcium...
<h3>Objectives</h3> To determine the risk of German compost workers developing chronic respiratory effects from long-term exposure to bioaerosols. <h3>Methods</h3> Respiratory health was determined in 74 currently exposed and 37 non-exposed controls after 13 years follow-up. In addition, 42 former (drop-outs) who left their work during follow-up period were also examined. symptoms working conditions assessed using identical questionnaires as at baseline. lung function measured same...
Specific (s)IgG antibodies against environmental and occupational antigens, especially from bacteria, moulds, yeasts, birds chemicals play an important role for hypersensitivity pneumonitis (HP). An increased serum level of sIgG is one criterion in the diagnostic procedure HP crucial detection triggering antigen successful avoidance further exposure. In contrast to specific IgE, concentrations healthy individuals vary greatly depending on antigen, which makes it difficult differentiate...
Work-related symptoms and diseases of 190 currently exposed compost workers, 59 former 38 nonexposed control subjects were investigated in a cross-sectional study. Using standardized questionnaire, participants asked for work-related symptoms, exposures to bioaerosols, atopic diseases, smoking habits. The underwent physical examination lung function test. In addition, total immunoglobulin (Ig) E, IgE specific environmental allergens moulds, IgG molds actinomycetes quantified. Compared...
It was the aim of this study to evaluate effect different devices on metal concentration in exhaled breath condensate (EBC) and prove whether working conditions welding companies result diverse composition metallic elements. The influence two collection (ECoScreen, ECoScreen2) detection elements EBC evaluated 24 control subjects. Properties ECoScreen a frequent use can alter content due contamination from components. ECoScreen2 turned out be favourable for assessment. Concentrations iron,...
Concerning possible harmful components of welding fumes, besides gases and quantitative aspects the respirable particle-inherent metal toxicity has to be considered.The objective this study was investigate effect markers leukotriene B4 (LTB4),prostaglandin E2 (PGE2) 8-isoprostane (8-Iso PGF2α) as well acid–base balance(pH) in exhaled breath condensate (EBC) 43 full-time gas arc welders (20 smokers) relation fume exposure. We observed different patterns iron, chromium nickel fumes EBC....
1. Domingo JL, Nadal M. Domestic waste composting facilities: a review of human health risks. Environ Int. 2009; 35(2): 382–389. CrossRef Google Scholar
The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation airway inflammation. Several studies indicate that the composition recovery biomarkers are affected by physical characteristics condensing device collecting circumstances. Additionally, there an apparent influence temperature, often level detection assay limiting factor. ECoScreen2 new, partly single-use disposable system designed studying different lung compartments. EBC samples were...
Abstract To quantify the subjective and cognitive impairment caused by wearing face masks at work, 20 men women (median age 47 years, range 19–65) were tested under different ergometer workloads while surgical mask, community FFP2 respirator or no mask in a randomized partially double-blinded design. Masks worn also workplace for four hours. Subjective was recorded questionnaires. Cognitive performance before after examination. feeling of heat, humidity, difficult breathing increased with...
Total mass and composition of welding fumes are predominantly dependent on the technique wire applied. The objective this study was to investigate impact techniques biological effect markers in exhaled breath condensate (EBC) 58 healthy welders. applied were gas metal arc with solid (GMAW) (n = 29) or flux cored (FCAW) 29). Welding fume particles collected personal samplers breathing zone inside helmets. Levels leukotriene B4 (LTB4), prostaglandin E2 (PGE2), 8-isoprostane (8-iso-PGF2α)...
BackgroundMiners are at particular risk for tuberculosis (TB) infection due to exposure silica dust and silicosis. The objectives of the present observational cohort study were determine prevalence latent TB (LTBI) among aged German underground hard coal miners with silicosis or chronic obstructive pulmonary disease (COPD) using two commercial interferon-gamma release assays (IGRAs) compare their performance respect predictors test positivity. MethodsBetween October 2008 June 2010,...
Welding fumes may produce adverse health effects in the respiratory tract. To assess relationship between exposure to welding and inflammation upper airways, 190 male welders were examined from WELDOX study (median age 40 yr, 54.7% smokers, 32.9% atopics). Inhalable collected breathing zone of during a single shift. Chromium (Cr), nickel (Ni), manganese (Mn), iron (Fe) measured welding-fume samples postshift nasal lavage fluid (NALF). In addition, numbers particles inflammatory biomarkers,...
In this study, 24 subjects (20–58 years) were exposed to carbon dioxide (CO2) at 770 ppm and 20 000 in an exposure laboratory for 4-h, including 2 × 15 min of cycling investigate the effects on acid-base balance, physiological responses, cognitive performance acute health. Capillary blood analysis, heart rate, respiratory divided attention, flexibility, sustained attention from Test Battery Attentional Performance (TAP), critical flicker fusion frequency (CFF), self-reported symptoms...
Stimulation of human polymorphonuclear neutrophils through ligation and cross-linking the low affinity Fc gamma RIIa RIIIb using mAb Fab F(ab')2 fragments led to transient intracellular calcium mobilization activation respiratory burst. engagement resulted in a different pattern flux, induction burst was significantly more effective than case RIIa. These data demonstrate that capacity transduce transmembrane signals itself contributes full cell activation. Treatment with fragment recognizing...