A5007892438- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Retinal Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Drug-Induced Ocular Toxicity
- Biomedical Research and Pathophysiology
- Cardiac, Anesthesia and Surgical Outcomes
- Intraocular Surgery and Lenses
- Retinoids in leukemia and cellular processes
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Renal Transplantation Outcomes and Treatments
- Conducting polymers and applications
- Organic Light-Emitting Diodes Research
- Immune Cell Function and Interaction
- Organic Electronics and Photovoltaics
- Anesthesia and Sedative Agents
- Ultrasound in Clinical Applications
- T-cell and B-cell Immunology
- Cardiac Arrest and Resuscitation
- Cerebral Venous Sinus Thrombosis
- Complement system in diseases
- Connexins and lens biology
Charité - Universitätsmedizin Berlin
2008-2023
Humboldt-Universität zu Berlin
2021-2023
Freie Universität Berlin
1997-2023
German Society of Medical Intensive Care and Emergency Medicine
2021-2022
Medical University of Vienna
2010-2021
Weatherford College
2021
Pain and Rehabilitation Medicine
2019
Vereinigung der Denkmalfachämter in den Ländern
2017
Bayerisches Landesamt für Denkmalpflege
2017
Niedersächsisches Ministerium für Wissenschaft und Kultur
2017
Patients with kidney failure are at increased risk of SARS-CoV-2 infection, making effective vaccinations a critical need. It is not known how well mRNA vaccines induce B and plasma cell responses in dialysis patients (DPs) or transplant recipients (KTRs) compared healthy controls (HCs). We studied humoral 35 HCs, 44 DPs, 40 KTRs. Markedly impaired anti-BNT162b2 were identified among KTRs DPs HCs. In the response was delayed (3 to 4 weeks after boost) reduced anti-S1 IgG IgA positivity 70.5...
Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name: Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine-induced immunity. We therefore comprehensively analyzed humoral cellular responses kidney transplant recipients after standard second...
Mortality from COVID-19 among kidney transplant recipients (KTR) is high, and their response to three vaccinations against SARS-CoV-2 strongly impaired. We retrospectively analyzed the serological of up five doses vaccine in KTR 27 December 2020 until 31 2021. Particularly, influence different dose adjustment regimens for mycophenolic acid (MPA) on fourth vaccination was analyzed. In total, 4277 1478 patients were Serological 19.5% after 1203 basic immunizations, increased 29.4%, 55.6%,...
Patients with kidney failure have notoriously weak responses to common vaccines. Thus, immunogenicity of novel SARS-CoV-2 vaccines might be impaired in this group. To determine vaccination patients chronic dialysis, we analyzed the humoral and T-cell response after two doses mRNA vaccine Tozinameran (BNT162b2 BioNTech/Pfizer). This observational study included 43 on dialysis before 21 days apart. Overall, 36 completed observation period until three weeks second dose 32 were further at week...
PurposeChronic kidney disease (CKD) is a major health-care burden. Increasing evidence suggests that considerable proportion of patients are affected by monogenic disorder.MethodsIn this study, the transplantation waiting list at Charité was screened for with undetermined cause CKD. By next-generation sequencing (NGS) we targeted all 600 genes described and associated or allied disorders.ResultsIn total, 635 were investigated. Of these, 245 individuals had known CKD (38.5%) which 119 proven...
Abstract Novel mRNA-based vaccines have been proven powerful tools to combat the global pandemic caused by SARS-CoV2 with BNT162b2 efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine induced immunity. We therefore comprehensively analyzed humoral cellular responses in kidney transplant recipients after prime-boost vaccination BNT162b2. As opposed all...
Abstract Mortality from COVID-19 among kidney transplant recipients (KTR) is high, and their response to three vaccinations against SARS-CoV-2 strongly impaired. We retrospectively analyzed serological of up five doses vaccine in KTR December 27, 2020, until 31, 2021. Particularly, the influence different dose adjustment regimens for mycophenolic acid (MPA) on fourth vaccination was analyzed. In total, 4.277 1.478 patients were Serological 19.5% after 1.203 basic immunizations, increased...
<h3>Objective</h3> To evaluate the performance of whole body (WB) MRI versus conventional (CON) in assessing active inflammatory lesions entire spine patients with established and clinically axial spondyloarthritis (SpA) using Spondyloarthritis Research Consortium Canada (SPARCC) index. <h3>Methods</h3> 32 consecutive SpA fulfilling modified New York criteria disease (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score ≥4) were scanned by sagittal WB CON spine. The MR images...
Abstract Background: Training in transesophageal echocardiography (TEE) is based on hands-on training the operating room, which time consuming and therefore limits its experience among anesthesiologists. Medical simulations have been successfully used for of invasive procedures many areas. This paper compares difference effectiveness teaching 11 basic TEE views using either e-learning, simulation or room 3 groups residents. Methods: We included 51 anesthesia intensive care residents all...
Abstract A multilayer, flexible, and transparent high-barrier system based on flexible plastic foils, polyethyleneterephthalate (PET) ethylene-tetrafluoroethylene-copolymer (ETFE), combined with vacuum-deposited, inorganic SiOx layers hybrid ORMOCER® varnish were prepared in different orders a semiproduction level. Barrier properties of systems, as water vapour transmission (WVTR) oxygen (OTR), measured studied connection surface energy, topography, adsorption properties. Correlations among...
The anesthetic effect of volatile anesthetics can be quantified by the minimum alveolar concentration (MAC) drug that prevents movement in response to a noxious stimulus 50% patients. underlying mechanism regarding how immobilization is achieved not thoroughly understood, but several drugs affect MAC. In this study, we investigated single IV bolus dose lidocaine on MAC sevoflurane humans.We determined for using Dixon "up-and-down" method 3 groups patients, aged 30 65 years, who underwent...
The encapsulation of the active layers (organic semiconductors, electrodes, transparent conductive oxides, etc.) organic electronic devices developed onto flexible polymeric substrates is one most challenging issues in rapidly emerging area electronics. importance for protection arises from fact that these are very sensitive when they subjected to atmosphere, since permeation atmosphere's water vapour (H2O) and oxygen (O gases induces corrosion effects, film delamination finally, failure...
Abstract A roll‐to‐roll manufactured ultra‐high permeation barrier film based on a multilayer stack of sputtered oxide layers and ORMOCER® interlayers is presented. The reproducible large‐area water vapor transmission rate less than 8·10 −5 g/(m 2 d) at ambient condition. has been evaluated as substrate for encapsulation flexible organic electronic devices.
Summary We measured carotid and brachial artery blood flow by Doppler ultrasound in 11 human volunteers, related these to cardiac index each other. The median ( IQR [range]) arterial was 0.334 (0.223–0.381 [0.052–0.563]) l.min −1 on the right 0.315 (0.223–0.369 [0.061–0.690]) left. 0.049 (0.033–0.062 [0.015–0.204]) 0.039 (0.027–0.054 [0.011–0.116]) Cardiac 3.2 (2.8–3.5 [1.9–5.4]) .m −2 . There a moderate good correlation between right‐and left‐sided flows (brachial: ρ = 0.45; carotid:...
Background. The novel immunosuppressive agent AEB071 is currently being evaluated for its capability to prevent rejection after kidney transplantation as a potential adjunct calcineurin inhibitor-based regimen. selective protein kinase C inhibitor and has been shown be well tolerated in humans. We here present extensive vitro studies that contribute the understanding of effects on human lymphocyte, natural killer (NK) cell dendritic (DC) action. Methods. impact several T-cell activation...
<h3>Background:</h3> Trials with healthy volunteers have shown that emergency ambulance transportation induces stress, which becomes evident by an increase in heart rate, blood pressure and plasma levels of stress hormones such as adrenaline, noradrenaline, cortisol prolactin. A study was undertaken to test the hypothesis may also lead patients acute coronary syndrome. <h3>Methods:</h3> Venous epinephrine, norepinephrine lactate well visual analogue scale (VAS) scores for pain anxiety were...
Cardiopulmonary bypass (CPB) induces hemolysis, which manifests as plasma free hemoglobin. We investigated in a post hoc analysis of single-center, blinded, controlled study whether the use novel hemoadsorption device (CytoSorb, CytoSorbents Europe GmbH, Berlin, Germany) affects hemolysis during CPB. A total 35 patients undergoing elective CPB surgery with an expected duration more than 120 min were included analysis. The was used 17 (intervention group) and not 18 (control group). primary...
Abstract Objective Patients with kidney failure have notoriously weak responses to common vaccines. Thus, immunogenicity of novel SARS-CoV-2 vaccines might be impaired in this group. To determine vaccination patients chronic dialysis, we analyzed the humoral and T-cell response after two doses mRNA vaccine Tozinameran (BNT162b2 BioNTech/Pfizer). Design, Settings, Participants This observational study included 43 on dialysis before 21 days apart. Overall, 36 completed observation period....