A5086540269- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Nanoparticles: synthesis and applications
- Cancer Cells and Metastasis
- Microfluidic and Capillary Electrophoresis Applications
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Bone Tissue Engineering Materials
- Parkinson's Disease Mechanisms and Treatments
- Lung Cancer Research Studies
- Neurological disorders and treatments
- interferon and immune responses
- Microfluidic and Bio-sensing Technologies
- Big Data and Business Intelligence
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA regulation and disease
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Prion Diseases and Protein Misfolding
- Metal and Thin Film Mechanics
- CRISPR and Genetic Engineering
- Genetic Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Advanced materials and composites
University of Bergen
2012-2024
Institute for Bioengineering of Catalonia
2007
Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream downstream manufacturing processes EV large-scale production, also focusing on post-processing technologies such surface bioengineering uploading studies to yield novel EV-based diagnostics advanced therapy medicinal products. focuses the quality, safety, efficacy issues of bioengineered drug candidates before first-in-human...
Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns sensitize cells other therapies, provide a new treatment strategy for drug-resistant tumors. Here we investigated the ability DNA methyltransferase (DNMT) inhibitor decitabine (DAC) increase sensitivity BC anthracycline antibiotic doxorubicin (DOX). Three cell lines representing different...
Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as treatment option for various solid tumors. Although epigenome modulation provides promising avenue treating resistant cancer types, more studies are required to evaluate its safety and ability normalize the aberrant transcriptional profiles. As deoxycytidine kinase (DCK)-mediated phosphorylation rate-limiting step DAC metabolic activation, we hypothesized that...
Personalized medicine is a new approach to modern oncology. Here, facilitate the application of extracellular vesicles (EVs) derived from lung cancer cells as potent advanced therapy medicinal products in cancer, EV membrane was functionalized with specific ligand for targeting purposes. In this role, most effective heptapeptide binding (PTHTRWA) used. The functionalization process surface performed through C- or N-terminal end heptapeptide. To prove activity EVs PTHTRWA, both model lipid...
Abstract Background Hazard and risk assessment of nanomaterials (NMs) face challenges due to, among others, the numerous existing nanoforms, discordant data conflicting results found in literature, specific application strategies such as grouping read-across, emphasizing need for New Approach Methodologies (NAMs) to support Next Generation Risk Assessment (NGRA). Here these are addressed a study that couples physico-chemical characterization with vitro investigations silico similarity...
Abstract Co ntact- de pendent i ntercellular t ransfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions bacteria also utilize this mechanism to spread adjacent cells potentially evade immune detection. However, little is known about the molecular underlying intercellular transfer process. Here, we present a novel microscopy-based screening method identify regulators cargo codeIT....
The bystander effect in cancer therapy is the inhibition or killing of tumor cells that are adjacent to those directly affected by agent used for treatment. In case chemotherapy, little known as how much and which mechanisms effects contribute elimination cells. This mainly due difficulty distinguish between targeted since both exposed pharmaceutical compound. We here studied interaction tamoxifen-treated human breast MCF-7 with their neighboring counterparts exploiting laminar flow...
Abstract To improve the wear resistance of articulating metallic joint endoprostheses, surfaces can be coated with titanium niobium nitride (TiNbN). Under poor tribological conditions or malalignment, occur on these implant in situ. This study investigated biological response human osteoblasts to particles generated from TiNbN‐coated hip implants. Abrasive were a simulator according ISO 14242‐1/−2 and extracted Proteinase K. Particle characteristics evaluated by electron microscopy energy...