A5101553813- Selenium in Biological Systems
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Iron Metabolism and Disorders
- Hydrogels: synthesis, properties, applications
- Adsorption and biosorption for pollutant removal
- Plant Micronutrient Interactions and Effects
- Nitrogen and Sulfur Effects on Brassica
- Folate and B Vitamins Research
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Supramolecular Self-Assembly in Materials
- Nanoparticle-Based Drug Delivery
- Genetic and phenotypic traits in livestock
- Genomics, phytochemicals, and oxidative stress
- Arsenic contamination and mitigation
- Graphene and Nanomaterials Applications
- Radioactivity and Radon Measurements
- Mercury impact and mitigation studies
- Berry genetics and cultivation research
- Biosensors and Analytical Detection
- Chromium effects and bioremediation
- Genetics and Physical Performance
- Bioactive Compounds and Antitumor Agents
- Aquaculture disease management and microbiota
University of Warsaw
2023-2025
Pomeranian Medical University
2012-2021
Read-Gene (Poland)
2012-2021
International Hereditary Cancer Center
2012-2021
West Pomeranian University of Technology
2009-2011
University of Szczecin
2006
Understanding of the etiology and pathogenesis pancreatic cancer (PaCa) is still insufficient. This study evaluated associations between concentrations selenium (Se) copper (Cu) in serum PaCa patients.The included 100 patients control subjects from same geographical region Poland. To determine average concentration Se, Cu, ratio Cu:Se Polish population, assay for Se Cu was performed 480 healthy individuals. Serum levels were measured using inductively coupled plasma mass spectrometry.In...
Plant-parasitic nematodes remain a significant challenge to agriculture and horticulture. Unfortunately, there is lack of rapid, efficient eco-friendly control methods. Nanomaterials, therefore, appear be promising source new plant protection strategies. In the current study, two nanosystems-based on one-component (Ag) or two-component (AgZn) colloidal systems-and an aqueous solution AgNO3, were explored for their potential in nematode control, using Meloidogyne incognita-the most...
Purpose It has been suggested that selenium deficiency is a risk factor for several cancer types. We conducted case-control study in Szczecin, region of northwestern Poland, on 95 cases lung cancer, 113 laryngeal and corresponding healthy controls. Methods measured the serum level established genotypes four variants selenoprotein genes (GPX1, GPX4, TXNRD2 SEP15). Selenium levels were after diagnosis but before treatment. calculated odds being diagnosed with or conditional genotype. Results...
Lung cancer is the most common adult malignancy accounting for largest proportion of related deaths. Iron (Fe) an essential trace element and a component several major metabolic pathways playing important role in many physiological processes. In this study we evaluated association between Fe concentration serum, iron metabolism parameters genetic variaton 7 genes involved anti-oxidative processes with incidence lung Poland.The included 200 patients matched healthy control subjects. We...
We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage cancer. measured among 205 patients matched controls. Cases controls sex, age smoking history (total pack-years, years since cessation former smokers). The odds ratio those highest quartile level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01–9.67, p < 0.01). association present smokers 16.8, CI:3.96−71.2, 0.01), but not current...
There is a need for sensitive and specific biomarkers the early detection of colorectal cancer. In this retrospective study, we assessed whether high blood copper level was associated with presence The measured among 187 cancer patients matched controls. Cases controls were sex, smoking status (yes/no) year birth. Among cases, mean 1031 µg/L (range 657 to 2043 µg/L) controls, 864 589 1433 µg/L). odds ratio those in highest quartile (versus lowest) 12.7 (95% CI: 4.98-32.3; p < 0.001). Of...
Selenium has attracted attention because of its antioxidant properties. Antioxidants protects cells from damage. Certain breakdown products selenium are believed to prevent tumor growth by enhancing the immune cell activity and suppressing development blood vessels. In this observational study, level was measured in a series patients Poland Estonia determine correlation between levels microelement colorectal cancer risk. A total 169 healthy controls were enrolled study after obtaining their...
Introduction Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported literature suggests that zinc may be related to prostate cancer. In this study we evaluated association serum levels and polymorphisms genes encoding zinc-dependent proteins with Poland. Methods The group consisted 197 affected healthy men. Serum were measured 5 single nucleotide MMP-1, MMP-2, MMP-7, MMP-13, MT2A genotyped. Results mean level was higher patients...
Background Observational studies have reported an inverse relationship between selenium status (blood or toenail) and the risk of laryngeal cancer; however, impact low serum level on survival has not been evaluated. Methods We conducted a prospective study 296 patients diagnosed with cancer in Szczecin, Poland. Serum was measured at diagnosis prior to treatment. Patients were followed from date death five years. Vital obtained by linkage Polish National Death Registry. Results The five-year...
Arsenic is recognized as a potent carcinogen at high concentrations, but the relationship between environmental arsenic and breast cancer risk has not well been studied. Most research focused on effect of in populations with endemic exposure, levels within normal limits. We sought to determine if blood predict other cancers among women northern Poland. The cohort consisted 1,702 healthy women, aged 40 above, identified 2010 2017. Blood level was determined by inductively coupled plasma mass...
The effect of treatment the Californian earthworm Eisenia fetida with preparations containing silver (Ag; in form either nanoparticles (AgNPs) or cations (AgNO3 solution)) and gold (Au; (AuNPs)) on its vitality was studied a laboratory experiment for 12, 48, 158 h. After observations were completed, total elemen content analysed after exposure to individual applied soil. Earthworms soil which they grown analysed. Measurements performed using inductively coupled plasma mass spectrometry...
Abstract Background Epidemiologic studies have demonstrated a relationship between selenium status and cancer risk among those with low levels. It is of interest to prospectively evaluate the women who reside in region ubiquitously Methods We performed nested case-control study baseline serum levels using data biological samples from 19,573 females that were participants biobanking initiative 2010 2014 Szczecin Poland. Cases included any incident ( n = 97) controls 184) no at or follow-up....
Cancer ranks among the top causes of illness and death globally. Nanotechnology holds considerable promise for enhancing effectiveness therapeutic diagnostic approaches in cancer treatment. Our study presents a promising strategy applying thiocompound nanomedicine therapy. first aimed to investigate biological properties new compound thiodiosgenin (TDG)—a derivative diosgenin—a natural with known antioxidant anticancer properties. current second compare efficacy diosgenin—functionalized gold...
Abstract Lung cancer is the leading cause of cancer-related death worldwide. Exposure to environmental and occupational carcinogens an important lung cancer. One these substances chromium, which found ubiquitously across planet. The International Agency for Research on Cancer has classified chromium(VI) as a human carcinogen. aim this study was assess whether serum chromium levels, well DNA variants in selected genes involved carcinogenesis, xenobiotic-metabolism, oxidative stress could be...
Abstract Background Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which involved in processes crucial for carcinogenesis such as angiogenesis, proliferation apoptosis. Several single nucleotide polymorphisms (SNPs) MMPs MTs that affect genes expression have been associated with cancer risk, including breast, lung colon. Methods The study group consisted of 648 unselected patients (299 breast cancer, 199 150 colon cancer) unaffected individuals. Five...
In this study, we examine the possibility of detecting PTFE microparticles by ICP-qMS equipped with O 2 dynamic reaction cell (DRC) and operated in single-particle mode.
1. Collective work. Prevention of Blindness and Visual Impairment, World Health Organization website www.who.int/blindness/causes/priority/en/index1.html. Accessed 30th June 2017. Google Scholar
All subjects analyzed in the study were divided into two groups. The from first group Polish women, positive for at least one of three founder mutations BRCA1 gene dominating Poland (5382insC, C61G, 4153delA). In second with breast cancers, unselected but negative mutation. Persons detected tumor considered as cases and others controls. case controls, control, paired regarding many criteria (e.g. age, family cancer history, cigarettes smoking), adnexectomy to achieve maximum similarity...
A novel class of hydrogels, rich in a variety functional groups capable interacting/complexing with metal ions, was successfully synthesized using acryloyl derivatives natural α-amino acids: ornithine and cystine. To enable to attach the polymer chain, δ-amino group modified an group, N,N'-bisacryloylcystine derived from cystine as cross-linker. The gel obtained through free radical polymerization. This hydrogel, composed only amino acids, has proven be competitive sorbent been effectively...
Background. Common carp, Cyprinus carpio, is a model organism within Teleostei. Oligopeptides are new and promising alternative source of amino acids in animal as well human nutrition. In common the membrane protein that transports oligopeptides across enterocyte encoded by gene PepT1 (SLC15A1). The aim this paper was to sequence (SLC15A1) carp. Materials methods. Intestine samples were isolated from six-week old Total RNA using Trizol method. Reverse transcription used synthesize cDNA. Two...
The relationships between the SNPs of cytochrome P450 gene (CYP19/PvuII), steroid 21-hydroxylase (P450c21) (CYP21/HpaII), 2 polymorphic sites estrogen receptor alpha (ER1/BglI and ER1/SnaBI), milk production traits Black-and-White cattle were analyzed. A total 472 cows included in study genotyped using PCR-RFLP. frequencies alleles for as follows: 0.923 - CYP19A, 0.077 CYP19B, 0.042 ER1/BglIA, 0.958 ER1/BglIG. For ER1/SnaBI, frequency allele was 0.960 that G 0.040. In CYP21, all AA (no...