Bartosz Kubisa
A5078393972- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Renal Transplantation Outcomes and Treatments
- Esophageal and GI Pathology
- Mechanical Circulatory Support Devices
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Polyomavirus and related diseases
- Organ and Tissue Transplantation Research
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Pneumothorax, Barotrauma, Emphysema
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Congenital Heart Disease Studies
- Trace Elements in Health
- RNA modifications and cancer
- Microbial infections and disease research
- Cancer Immunotherapy and Biomarkers
- MXene and MAX Phase Materials
Pomeranian Medical University
2015-2024
University of Szczecin
2014-2024
Medical University of Warsaw
2024
Royal College of Surgeons in Ireland
2023
Heliodor Swiecicki Clinical Hospital
2023
Poznan University of Medical Sciences
2023
University College Cork
2023
Fusion Academy
2020
Fusion (United States)
2020
Clinical Research Consortium
2020
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization 110 tumors 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, gender. Proteomic phosphoproteomic data illuminated downstream copy number aberrations, somatic...
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few therapeutic options. We characterized the proteogenomic landscape LSCC, providing deeper exposition LSCC biology potential implications. identify NSD3 as an alternative driver in FGFR1-amplified tumors and low-p63 overexpressing target survivin. SOX2 is considered undruggable, but our analyses provide rationale for exploring chromatin modifiers such LSD1 EZH2 to SOX2-overexpressing tumors. Our data support...
IntroductionAdjuvant platinum-based chemotherapy is standard treatment for surgically resected stage II to IIIA NSCLC, but the relapse rate high. The preferentially expressed antigen of melanoma (PRAME) tumor in two-thirds NSCLC and offers an attractive target antigen-specific immunization. A phase I dose escalation study assessed safety immunogenicity a PRAME immunotherapeutic consisting recombinant plus proprietary immunostimulant AS15 patients with (NCT01159964).MethodsPatients...
We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage cancer. measured among 205 patients matched controls. Cases controls sex, age smoking history (total pack-years, years since cessation former smokers). The odds ratio those highest quartile level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01–9.67, p < 0.01). association present smokers 16.8, CI:3.96−71.2, 0.01), but not current...
Chronic obstructive pulmonary disease, cystic fibrosis and usual interstitial pneumonia are three most common indications for lung transplantation (LuTx) in Poland. As a result of irreversible destruction parenchyma extended respiratory insufficiency that appear afterwards, it is crucial to estimate the reserve gas exchange each before during surgery. Altering conditions require adaptation circulatory system as well. In some cases use extracorporeal life support appears be necessary undergo...
Transplanted lungs suffer worse outcomes than other organ transplants with many developing chronic lung allograft dysfunction (CLAD), diagnosed by physiologic changes. Histology of transbronchial biopsies (TBB) yields little insight, and the molecular basis CLAD is not defined. We hypothesized that gene expression in TBBs would reveal nature distinguish from changes due simply to time posttransplant. Whole-genome mRNA profiling was performed microarrays 498 prospectively collected INTERLUNG...
Abstract Lung cancer is the leading cause of cancer-related death worldwide. Exposure to environmental and occupational carcinogens an important lung cancer. One these substances chromium, which found ubiquitously across planet. The International Agency for Research on Cancer has classified chromium(VI) as a human carcinogen. aim this study was assess whether serum chromium levels, well DNA variants in selected genes involved carcinogenesis, xenobiotic-metabolism, oxidative stress could be...
Pulmonary resections after pneumonectomy due to metastases or metachronous non-small cell lung cancer (NSCLC) are rare because of the high potential risk second procedure and uncertain long-term results. On basis our series (largest in Europe) we tried assess survival patients treated stage IV NSCLC.Retrospective analysis was carried out on 18 at department by followed additional resection years 1981-2002 (15 males 3 females, 44-69 years, mean 57). Eleven pneumonectomies were performed right...
In lung transplantation, antibody-mediated rejection (AMR) diagnosed by ISHLT criteria is uncommon compared to other organs, and previous studies failed find molecular AMR (ABMR) in biopsies. However, understanding of ABMR has changed with the recognition that kidney transplants often DSA-negative associated NK cell transcripts. We therefore searched for a similar ABMR-like state transbronchial biopsies (TBBs) using gene expression microarray results from INTERLUNG study (#NCT02812290)....
Lung transplantation is an acceptable treatment option for various end-stage pulmonary diseases, but long-term survival currently lags behind that after of other solid organs. We hypothesized gene transfer to grafts before may be a useful method deliver antioxidant and/or anti-inflammatory genes modulate these processes. For this purpose, we assessed the efficiency and effects on lung function synthetic polycation, linear polyethylenimine (PEI), airway instillation lungs Fischer rats....
Background/Aim: The analysis of prognostic factors is important to identify determinants disease-free survival (DFS) and overall (OS) in resected non-small-cell lung cancer (NSCLC). Patients Methods: We examined baseline characteristics associated with DFS OS among 757 patients resected, histologically proven, MAGE-A3-positive Stage IB-IIIA NSCLC assigned placebo the MAGRIT study (NCT00480025). explored that could predict using Cox regression models. Results: multivariate showed lower nodal...
Abstract: Tracheostomy is a routinely done procedure in the setting of intensive care unit (ICU) patients requiring prolonged mechanical ventilation. There are two ways making tracheostomy: an open surgical tracheostomy and percutaneous dilatational tracheostomy. Percutaneous associated with fewer complications than In this study, we would like to compare both techniques performing ICU present possible complications, methods diagnosing treating minimizing their risk. Keywords: tracheostomy,...
Background: Primary graft dysfunction (PGD) is a form of acute lung injury (ALI) that occurs within 72 h after transplantation (LuTx) and the most common early complication procedure. PGD diagnosed graded based on ratio partial pressure arterial oxygen to fraction inspired chest X-ray results. grade 3 increases recipient mortality chance chronic allograft (CLAD). Method: The aim this retrospective study was identify new risk factors. inclusion criteria were met by 59 patients, who all...
The effect of 1,25-dihydroxycholecalciferol (calcitriol, vitamin D3) with a low-calcium diet on the acute lung allograft rejection in rat unilateral left transplantation model was evaluated. Three groups were studied (n = 5, male Brown-Norway to Fischer F344, 235 ± 15 g body weight): calcitriol and diet, normal diet. Calcitriol (4 μg/kg/day) injected intraperitoneally for 5 days, starting from day transplantation. In addition, two non-transplantation compared: 3, Brown-Norway) measure level...