A5009543050- Lung Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Myasthenia Gravis and Thymoma
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Lung Cancer Research Studies
- Trauma Management and Diagnosis
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Organ and Tissue Transplantation Research
- Renal Transplantation Outcomes and Treatments
- Esophageal and GI Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
- Multiple and Secondary Primary Cancers
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pneumothorax, Barotrauma, Emphysema
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Pituitary Gland Disorders and Treatments
Université de Strasbourg
2014-2025
University of Luxembourg
2020-2025
Hôpital Kirchberg
2025
Regenerative NanoMedicine
2013-2022
Inserm
2018-2022
Hôpital Civil, Strasbourg
2011-2022
Hôpitaux Universitaires de Strasbourg
2011-2021
Society of Thoracic Surgeons
2017
Institut du Thorax
2017
Centre Hospitalier Universitaire de Nantes
2017
Background The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendations of SP. Methods multidisciplinary Task Force addressed 12 key questions on pneumothorax, using ERS methodology development. Systematic searches were performed in MEDLINE Embase. Evidence was synthesised by conducting meta-analyses, if possible, or...
Pathologic processes that may involve the chest wall include congenital and developmental anomalies, inflammatory infectious diseases, soft-tissue bone tumors. Many of these have characteristic radiologic appearances allow definitive diagnosis. Sternal deformities can be visualized at radiography their severity quantified with computed tomography (CT). In cervical rib, CT multiplanar reconstruction demonstrate relevant anatomic detail relationship between deformity arterial compression....
Nutritional assessment is not included yet as a major recommendation in lung cancer guidelines. The purpose of this study was thus to assess the influence on surgical outcome nutritional status patients with primary undergoing lobectomy. We queried Epithor, national clinical database French Society Thoracic and Cardiovascular Surgery, identified retrospective cohort 19 635 having undergone lobectomy for years 2005–11. Their categorized according WHO definition: underweight (BMI < 18.5): 857...
We evaluated KRAS (mKRAS (mutant KRAS)) and BRAF (mBRAF BRAF)) mutations to determine their prognostic potential in assessing patients with colorectal cancer (CRC) for lung metastasectomy.Data were reviewed from 180 a diagnosis of CRC who underwent metastasectomy between January 1998 December 2011.Molecular analysis revealed mKRAS 93 (51.7%), mBRAF 19 (10.6%). In univariate analyses, overall survival (OS) was influenced by thoracic nodal status (median OS: 98 months pN-, 27 pN+, P<0.0001),...
Identifying patients who will experience lung cancer recurrence after surgery remains a challenge. We aimed to evaluate whether mutant forms of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) (mEGFR mKRAS) are useful biomarkers in resected non-small cell (NSCLC).We retrospectively reviewed data from 841 underwent molecular testing for NSCLC between 2007 2012.mEGFR was observed 103 (12.2%), mKRAS 265 (31.5%). The median overall survival (OS) time...
We aimed to evaluate whether EGFR mutations (mEGFR) and KRAS amino acid substitutions can predict first site of recurrence or metastasis after non-small-cell lung cancer (NSCLC) surgery.Data were reviewed from 481 patients who underwent thoracic surgery for NSCLC between 2007 2012.Patients with G12C developed significantly more bone metastases compared the remainder cohort (59% vs 16%, P<0.0001). This was confirmed in multivariate analysis (MA) (odds ratio (OR): 0.113 (95% confidence...
Resection of pulmonary metastases originating from colorectal cancer is increasingly considered. While several adverse risk factors for long-term outcome are known, the selection patients who may benefit surgery remains unclear. In particular, few studies have addressed impact lymph node involvement, and signification hilar or mediastinal level extent. We retrospectively reviewed data 320 operated in two thoracic departments between 1992 2011. Appropriate statistical tests were used to...
In order to provide recommendations regarding implementation of computed tomography (CT) screening in Europe the ESTS established a working group with eight experts field. On background current situation CT and available evidence, ten have been prepared that cover essential aspects be taken into account when considering Europe. These issues are: (i) Implementation Europe, (ii) Participation thoracic surgeons programs, (iii) Training clinical profile for participating (iv) use minimally...
Abstract The majority of lung cancer patients have tumor‐derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect and tumor 34 who underwent bronchoscopy for cancer, including 11 small cell (SCLC) 23 nonsmall (NSCLC) (12 adenocarcinomas, squamous carcinomas) 20 controls. Allelotyping was performed with selected panel 12 microsatellites from 9 chromosomal regions 3p21, 3p24, 5q, 9p, 9q, 13q, 17p,...
Non-small cell lung cancers (NSCLC), in particular adenocarcinoma, are often mixed with normal cells. Therefore, low sensitivity of direct sequencing used for K-Ras mutation analysis could be inadequate some cases. Our study focused on the possibility to increase detection mutations cases tumour cellularity. Besides sequencing, we wild-type hybridisation probes and peptide-nucleic-acid (PNA)-mediated PCR clamping detect at codons 12 13, 114 routine consecutive NSCLC frozen surgical tumours...