A5062963552- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Chemical Analysis and Environmental Impact
- Nutritional Studies and Diet
- Carcinogens and Genotoxicity Assessment
- Thyroid Disorders and Treatments
- Obesity, Physical Activity, Diet
- Child and Adolescent Psychosocial and Emotional Development
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Trace Elements in Health
- Noise Effects and Management
- Gestational Diabetes Research and Management
- Neuroscience of respiration and sleep
- Selenium in Biological Systems
- Sleep and related disorders
- Climate Change and Health Impacts
- Fluoride Effects and Removal
- Microplastics and Plastic Pollution
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015-2024
Universitat Jaume I
2015-2024
Universitat de València
2015-2024
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2015-2024
Instituto de Salud Carlos III
2017-2024
Barcelona Institute for Global Health
2023
Center for Research in Environmental Epidemiology
2023
Centro Nacional de Microbiologia
2023
Universidad Autónoma de Nuevo León
2022
Basque Government
2022
Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) persist in the environment are found relatively high concentrations animal livers. Studies humans have reported inconsistent associations between PFOA liver enzymes.We examined cross-sectional association serum PFOS with markers of function adults.The C8 Health Project collected data on 69,030 persons; these, a total 47,092 adults were included present analysis. Linear regression models fitted for natural log (ln)-transformed...
Animal studies suggest that perfluorocarbons (PFCs) may alter sexual maturation. Relationships of human PFC exposure with puberty are not clear. We conducted a cross-sectional study to investigate whether perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) were associated indicators maturation in 2005–2006 survey residents PFOA water contamination from the Mid-Ohio Valley. Participants 3076 boys 2931 girls aged 8–18 years. They classified as having reached based on either...
Animal studies suggest that some perfluoroalkyl acids (PFAAs), including perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA) may impair thyroid function. Epidemiological findings, mostly related to adults, are inconsistent.We investigated whether concentrations of PFAAs were associated with function among 10,725 children (1-17 years age) living near a Teflon manufacturing facility in the Mid-Ohio Valley (USA).Serum levels thyroid-stimulating hormone...
BackgroundExposure to xenoestrogens during pregnancy may disturb the development and function of male sexual organs.ObjectiveIn this study we aimed determine whether combined effect environmental estrogens measured as total effective xenoestrogen burden (TEXB) is a risk factor for urogenital malformations.MethodsIn case–control study, nested in mother–child cohort (n = 702) established at Granada University Hospital, compared 50 newborns with diagnosis cryptorchidism and/or hypospadias 114...
<h3>Background</h3> Air pollution from traffic has been associated with cardiorespiratory diseases in children and adults, but there is little information on its potential neurotoxic effects. This study aimed to investigate the association between exposure nitrogen dioxide (NO<sub>2</sub>), as a marker of traffic-related air pollution, cognitive development children. <h3>Methods</h3> A population-based birth cohort southern Spain was followed age 4 years for 1 year. Complete data analyses...
Background: The presence of perfluoroalkyl acids (PFAAs) in breast milk has been documented, but their lactational transfer rarely studied. Determination the elimination rates these chemicals during breastfeeding is important and critical for assessing exposure mothers infants.Objectives: We aimed to investigate association between maternal serum concentrations perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic (PFNA), perfluorohexane (PFHxS). For a subset...
Iodine is the main constituent of thyroid hormones, which in turn are required for fetal brain development. However, relation between iodine intake during pregnancy, function, and child neurodevelopment needs further evaluation. The authors assessed association maternal from diet supplements pregnancy neonatal function with infant neurodevelopment. Mental Development Index Psychomotor (PDI) 691 children were obtained 2005 2007 using Bayley Scales Infant at age 1 year a prebirth cohort...
Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy a period of enhanced tissue plasticity fetus and mother be critical window PFAS exposure susceptibility.We evaluated associations between exposures outcomes in pregnant women.We analyzed 1,240 women from Spanish INMA [Environment Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with...
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body evidence suggests that exposure adverse stressors during early leads developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related inequalities from onwards. To address these public challenges, many European pregnancy childhood cohorts have been established over last 30 years. The enormous...
Background: Exposure to some perfluoroalkyl substances (PFAS), such as perfluorohexane sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane (PFOS), and perfluoro nonanoic acid (PFNA), may alter levels of sex hormones insulinlike growth factor1 (IGF1) in animals.Human studies on this topic are scarce, none have been conducted young children.oBjectives: We investigated the relationship between PFAS estradiol, total testos terone, IGF1 2,292 children (6-9 years age) from C8 Health...
Gestational weight gain differs according to pre-pregnancy body mass index and is related the risks of adverse maternal child health outcomes. charts for women in different groups enable identification offspring at risk We aimed construct gestational reference underweight, normal weight, overweight, grades 1, 2 3 obese compare these with those obtained uncomplicated term pregnancies. used individual participant data from 218,216 pregnant participating 33 cohorts Europe, North America,...
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL;...
Background: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce inconsistent. Objectives: We estimated associations between prenatal PFAS exposures outcomes relevant to risk, including a composite CM-risk score. Methods: measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) in maternal plasma (first trimester)....
There are limited data on the associations between maternal or newborn and child exposure to perfluoroalkyl acids (PFAAs), including perfluorooctanoate (PFOA) perfluorooctane sulfonate (PFOS). This study provides an opportunity assess association PFAA concentrations in mother-child pairs a population exposed PFOA via drinking water.We aimed determine relationship serum examine how child:mother ratio varies with child's age, sex, drinking-water concentration, reported bottled water use,...